149577-05-9

Basic information

• Product Name: m-PEG2-acid
• Synonyms: m-PEG2-acid;mPEG2-COOH
• CAS NO: 149577-05-9
• Molecular Formula: C₆H₁₂O₄
• Molecular Weight: 148.15708
• Mol File: 149577-05-9.mol

Chemical Properties

• Boiling Point: 244.2±20.0 °C(Predicted)
• Appearance: /
• Density: 1.098±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.28±0.10(Predicted)
• CAS DataBase Reference: m-PEG2-acid(CAS DataBase Reference)
• NIST Chemistry Reference: m-PEG2-acid(149577-05-9)
• EPA Substance Registry System: m-PEG2-acid(149577-05-9)

Safety Data

• Hazardous Substances Data: 149577-05-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
m-PEG2-acid is used as a PEGylation agent for improving the pharmacokinetic properties of therapeutic proteins and peptides. The PEGylation process enhances the solubility, stability, and circulation time of these biomolecules in the body, leading to better therapeutic efficacy and reduced immunogenicity.
Used in Drug Delivery Systems:
In the field of drug delivery, m-PEG2-acid is utilized as a key component in the synthesis of polymer-drug conjugates. The stable amide bond formed between the terminal carboxylic acid and primary amine groups of drug molecules allows for the creation of conjugates with controlled release properties, improving the drug's bioavailability and targeting capabilities.
Used in Diagnostics and Imaging:
m-PEG2-acid is employed as a PEGylation agent for enhancing the solubility and stability of imaging agents, such as contrast agents for magnetic resonance imaging (MRI) or optical imaging agents. The increased solubility and circulation time provided by the PEG spacer can lead to better imaging results and reduced side effects.
Used in Biomaterials and Tissue Engineering:
In the realm of biomaterials and tissue engineering, m-PEG2-acid is used as a component in the design of hydrogels and scaffolds. The hydrophilic PEG spacer can improve the biocompatibility, swelling properties, and overall performance of these materials, making them more suitable for various biomedical applications, such as wound healing, drug delivery, and cell culture.
Used in Cosmetics and Personal Care:
In the cosmetics and personal care industry, m-PEG2-acid is used as an ingredient in the formulation of creams, lotions, and other skincare products. The PEGylation process can improve the solubility, stability, and skin permeability of active ingredients, leading to enhanced efficacy and reduced irritation potential.

Upstream product

• 109-86-4 2-methoxy-ethanol 
• 140-88-5 ethyl acrylate 

Downstream Products

• 1226795-21-6 6-fluoro-2-(4'-N-(2''-(2''-methoxyethoxy)acetamido)phenyl)benzothiazole 
• 1360551-17-2 5-(4-{1-[5-(2-methoxy-ethoxymethyl)-[1,2,4]oxadiazol-3-yl]-1,2-dimethyl-propyl}-phenyl)-pyrimidin-2-ylamine 

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