150012-75-2

Basic information

• Product Name: (2Z,2'Z)-2,2'-(1,4-Dihydroquinoxaline-2,3-diylidene)bis(1-phenylethanone)
• Synonyms: (2Z,2'Z)-2,2'-(1,4-Dihydroquinoxaline-2,3-diylidene)bis(1-phenylethanone);(2Z)-2-[(3Z)-3-phenacylidene-1,4-dihydroquinoxalin-2-ylidene]-1-phenylethanone
• CAS NO: 150012-75-2
• Molecular Formula: C₂₄H₁₈N₂O₂
• Molecular Weight: 366.41192
• Mol File: 150012-75-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2Z,2'Z)-2,2'-(1,4-Dihydroquinoxaline-2,3-diylidene)bis(1-phenylethanone)(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z,2'Z)-2,2'-(1,4-Dihydroquinoxaline-2,3-diylidene)bis(1-phenylethanone)(150012-75-2)
• EPA Substance Registry System: (2Z,2'Z)-2,2'-(1,4-Dihydroquinoxaline-2,3-diylidene)bis(1-phenylethanone)(150012-75-2)

Safety Data

• Hazardous Substances Data: 150012-75-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(2Z,2'Z)-2,2'-(1,4-Dihydroquinoxaline-2,3-diylidene)bis(1-phenylethanone) is used as a synthetic intermediate for the development of various organic compounds. Its quinoxaline core and 1-phenylethanone groups provide a versatile platform for chemical reactions and modifications, enabling the synthesis of a wide range of molecules with diverse properties and applications.
Used in Medicinal Chemistry:
(2Z,2'Z)-2,2'-(1,4-Dihydroquinoxaline-2,3-diylidene)bis(1-phenylethanone) is used as a lead compound in the discovery and development of new pharmaceutical agents. Its unique structure may possess biological activities that can be harnessed for therapeutic purposes. Further research is required to explore its potential as a medicinal compound and to optimize its properties for specific applications in the pharmaceutical industry.

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 70590-93-1 (2Z,4Z)-3,4-Dihydroxy-1,6-diphenyl-hexa-2,4-diene-1,6-dione 
• 139266-61-8 (2Z,4Z)-1,6-diphenyl-3,4-dihydroxy-2,4-hexadiene-1,6-dione 
• 98-86-2 acetophenone 

Relevant articles and documents

Solution, solid state structure and fluorescence studies of 2,3-functionalized quinoxalines: Evidence for a π-delocalized keto-enamine form with N-H···O intramolecular hydrogen bonds

Three quinoxaline derivatives 3, 4 and 5 were prepared by condensation of tetraones RC(=O)-CH2-C(=O)-(=O)-CH2-C(=O)R [1, R = Ph; 2, R = neo-Pen] with o-phenylenediamine or (R,R)-1,2-diaminocyclohexane. 1H, 13C a

2,3-Bifunctionalized quinoxalines: Synthesis, DNA interactions and evaluation of anticancer, anti-tuberculosis and antifungal activity

A variety of 2,3-bifunctionalized quinoxalines (6-14) have been prepared by the condensation of 1,6-disubstituted-hexan-1,3,4,6-tetraones (1-4) with o-phenylenediamine, (R,R)-1,2-diaminocyclohexane and p-nitro-o-phenylenediamine. It is concluded that strong intramolecular N-H-O bonds in the favoured keto-enamine form may be responsible for the minimal biological activities observed in DNA footprinting, anti-tubercular, anti-fungal and anticancer tests with these hyper π-conjugated quinoxaline derivatives. However, subtle alteration by addition of a nitro group affecting the charge distribution confers significant improvements in biological effects and binding to DNA.