150464-08-7

Basic information

• Product Name: ethyl 2-amino-2-cyanoacetate oxalate
• Synonyms: ethyl 2-amino-2-cyanoacetate oxalate
• CAS NO: 150464-08-7
• Molecular Formula: C7H10N2O6
• Molecular Weight: 218.17
• Mol File: 150464-08-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-amino-2-cyanoacetate oxalate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-amino-2-cyanoacetate oxalate(150464-08-7)
• EPA Substance Registry System: ethyl 2-amino-2-cyanoacetate oxalate(150464-08-7)

Safety Data

• Hazardous Substances Data: 150464-08-7(Hazardous Substances Data)

Upstream product

• 144-62-7 oxalic acid 
• 3849-21-6 ethyl cyanoglyoxylate-2-oxime 

Downstream Products

• 76182-22-4 ethyl 5-amino-1-(p-methoxybenzyl)imidazole-4-carboxylate 
• 68462-61-3 ethyl 5‐amino‐1‐benzyl‐1H‐imidazole‐4‐carboxylate 
• 83566-38-5 diethyl 5-aminoimidazole-2,4-dicarboxylate 
• 76182-27-9 ethyl 1-benzyl-5-bromoimidazole-4-carboxylate 
• 76182-25-7 ethyl 1-benzyl-5-chloroimidazole-4-carboxylate 
• 33235-31-3 5-fluoro-1H-imidazole-4-carboxylic acid ethyl ester 
• 21190-16-9 5-amino-1H-imidazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

Preparative route to 2-ethoxycarbonylimidazole-4-phosphonate and diethyl imidazole-2,4-dicarboxylate

Practical synthesis of 2-ethoxycarbonylimidazole-4-phosphonate (1a) and diethyl imidazole-2,4-dicarboxylate (1b) are described.

Purines, Pyrimidines, and Imidazoles. Part 53. Synthesis of Some 5-Halogeno-analogues of Metiamide and Cimetidine

Ethyl 5-chloroimidazole-4-carboxylate has been prepared by diazotisation of ethyl 5-amino-1-(di-O-isopropylidene-α- or α,β-D-mannofuranosyl)imidazole-4-carboxylate, reaction of the diazonium salt with copper(I) chloride and removal of the 1-substituent with hydrochloric acid, or by similar conversion of ethyl 5-amino-1-t-butylimidazole-4-carboxylate to ethyl 1-t-butyl-5-chloroimidazole-4-carboxylate, and removal of the t-butyl group with hydrogen bromide.Ethyl 5-fluoroimidazole-4-carboxylate has been prepared from ethyl 5-amino-1-t-butylimidazole-4-carboxylate by diazotisation and photolysis in the presence of tetrafluoroboric acid.Ethyl 5-chloroimidazole-4-carboxylate and ethyl 5-fluoroimidazole-4-carboxylate have been converted into the corresponding alcohols by reaction with lithium aluminium hydride. 5-Chloro-4-(hydroxymethyl)imidazole has also been prepared by electrolysis of 5-chloroimidazole-4-carboxylic acid at mercury cathode. 5-Chloroimidazole has been converted into the 5-chloroimidazolyl analogues of metiamide and cimetidine by a sequence of reactions, and 5-fluoroimidazole has been similarly converted into the 5-fluoro-analogue of metiamide.The metiamide and cimetidine analogues were found to be histamine H2-receptor antagonists.