150807-99-1

Basic information

• Product Name: 2,4-BIS(METHYLSULFANYL)-6-OXO-1,6-DIHYDRO-5-PYRIMIDINECARBONITRILE
• Synonyms: 2,4-BIS(METHYLSULFANYL)-6-OXO-1,6-DIHYDRO-5-PYRIMIDINECARBONITRILE
• CAS NO: 150807-99-1
• Molecular Formula: C₇H₇N₃OS₂
• Molecular Weight: 213.28
• Mol File: 150807-99-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-BIS(METHYLSULFANYL)-6-OXO-1,6-DIHYDRO-5-PYRIMIDINECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-BIS(METHYLSULFANYL)-6-OXO-1,6-DIHYDRO-5-PYRIMIDINECARBONITRILE(150807-99-1)
• EPA Substance Registry System: 2,4-BIS(METHYLSULFANYL)-6-OXO-1,6-DIHYDRO-5-PYRIMIDINECARBONITRILE(150807-99-1)

Safety Data

• Hazardous Substances Data: 150807-99-1(Hazardous Substances Data)

Upstream product

• 17823-58-4 ethyl 2-cyano-3,3-di(methylsulfanyl)acrylate 
• 14527-26-5 2-methylisothiourea sulphate 
• 2986-19-8 carbamimidothioic acid methyl ester 
• 3490-92-4 methyl 2-cyano-3,3-bis(methylsulfanyl)acrylate 
• 1071-37-0 2-ethylisothiourea hydrobromide 

Downstream Products

• 1374158-27-6 C₁₈H₂₀N₆O₂S 
• 1374158-25-4 C₁₈H₂₀N₆O₃S 
• 1374158-23-2 C₂₉H₃₃N₉O₃ 
• 1374158-17-4 C₁₂H₁₁N₅O₃S₂ 
• 1374158-13-0 C₁₂H₁₁N₅O₄S₂ 
• 1374158-15-2 C₁₂H₁₃N₅O₄S₂ 
• 1374158-21-0 2,4-bis(4-(4-acetylpierazin-1-yl)phenylamino)-6-oxo-1,6-dihydropyrimidine-5-carboxamide 

Relevant articles and documents

Chloropyrimidines as a new class of antimicrobial agents

In the course of our investigations of pyrimidines as antimycotic agents, we have idenified a sub-class, with significant in vitro activity agains mycobacteria. The salient feature of these pyrimidine derivatives (3a o and 7a,b) is their appended aryl, heteroaryl and alkylthio subst ituent a position 6 and also alkylthio substituent at position 2. The rational design, synthesis, and evaluation of the in vitro antibacterial activity against six pathogenic bacteria including virulent and non-virulent strains of M cobacterium tuberculosis is described. Some of the synthesized compounds (3c, 3h, 3i, 3o) have displayed only potent in vitro antimycobacterial activity with MIC of 0.75 μ/mL excep 3i which also demonstrated activity against Escherichia coli a 12.5 μg/mL concentration. Only two compounds, 3a and 3b, demonstrated antibacterial activity agains Pseudomonas aeruginosa and E. coli with MIC 12.5 μg/mL. All the synthesized compounds were also evaluated for their antimycotic activity agains five pathogenic fungi but only some of them 3j n and 7a,b were found most potent against Aspergillus fumigatus and Trichophyton mentagrophytes. Copyright

OXYPYRIMIDINES AS SYK MODULATORS

The present invention is directed to compounds of formula (I) and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which arc inhibitor of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

Suitably functionalised pyrimidines as potential antimycotic agents

Various suitably functionalised pyrimidine derivatives have been synthesized to explore their potential as antimycotic agents. Some of the synthesized compounds 4c, 4d, 8a-e have shown highly significant in vitro antifungal activity against five human pathogenic fungi. (C) 2000 Elsevier Science Ltd. All rights reserved.

Chemotherapeutic agents: Part XXIII - Synthesis of π-deficient pyrimidines and fused pyrimidines as leishmanicides

Various ?-deficient pyrimidines and fused purimidines have been synthesized and evaluated for their leishmanicidal activity against L. donovani.