151293-15-1

Basic information

• Product Name: 5-Amino-3-(4-methylphenyl)pyrazole
• Synonyms: 5-AMINO-3-(4-METHYLPHENYL)PYRAZOLE;5-P-TOLYL-2H-PYRAZOL-3-YLAMINE
• CAS NO: 151293-15-1
• Molecular Formula: C₁₀H₁₁N₃
• Molecular Weight: 173.21
• Mol File: 151293-15-1.mol

Chemical Properties

• Boiling Point: 438 °C at 760 mmHg
• Flash Point: 248.8 °C
• Appearance: /
• Density: 1.196 g/cm³
• Vapor Pressure: 7.15E-08mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: 5-Amino-3-(4-methylphenyl)pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-3-(4-methylphenyl)pyrazole(151293-15-1)
• EPA Substance Registry System: 5-Amino-3-(4-methylphenyl)pyrazole(151293-15-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 151293-15-1(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
5-Amino-3-(4-methylphenyl)pyrazole is used as a building block for the synthesis of pharmaceutical compounds due to its pyrazole core and the presence of an amine and an aromatic moiety, which indicate potential for interactions with biological targets.
Used in Drug Discovery:
5-Amino-3-(4-methylphenyl)pyrazole is used as a valuable compound for research and development in drug discovery, as its structure suggests potential applications in the design and development of new therapeutic agents.
Used in Chemical Biology:
5-Amino-3-(4-methylphenyl)pyrazole is used in chemical biology for studying its interactions with biological targets and exploring its potential as a tool for understanding biological processes and developing new therapeutic strategies.

InChI:InChI=1/C10H11N3/c1-7-2-4-8(5-3-7)9-6-10(11)13-12-9/h2-6H,1H3,(H3,11,12,13)

Upstream product

• 614-16-4 Benzoylacetonitrile 
• 7391-28-8 p-tolueneacetonitrile 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 78583-85-4 (E)-3-Chloro-3-p-tolyl-acrylonitrile 
• 17196-75-7 3-amino-3-p-tolylacrylonitrile 

Downstream Products

• 331422-54-9 5,7-Dimethyl-2-(4-tolyl)pyrazolo[1,5-a]pyrimidine 
• 528833-87-6 5-phenyl-2-(p-tolyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 

Relevant articles and documents

Molecular docking design and one-pot expeditious synthesis of novel 2,5-diarylpyrazolo[1,5-a]pyrimidin-7-amines as anti-inflammatory agents

Abstract A series of novel 2,5-diarylpyrazolo[1,5-a]pyrimidin-7-amines were designed as COX-2 inhibitors by molecular docking studies and their synthesis was accomplished via an expeditious one-pot reaction. Structures of the compounds were established by

Synthesis of pyrazolo[5′,1′:2,3]pyrimido[4,5-b][1,4]- benzoxazines, a new heterocyclic ring system from 5(3)-aminopyrazoles

A series of pyrazolo[5′,1′:2,3]pyrimido[4,5-b][1,4]benzoxazines (4a-n), a new heterocyclic ring system has been synthesized starting from 2H-3-oxo-[1,4]-benzoxazines (1a-d) and 5(3)-aminopyrazoles (3a-d) via the intermediates 3-chloro-2-formylidine-1,4-be

Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation

A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1,5-a]pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established. A variety of substituents was tolerated at the 2 and 5 positions, including functionalized aryls, heterocycles, and alkyl groups.

Study of regioselectivity of reactions between 3(5)-aminopyrazoles and 2-acetylcycloalkanones

Regioselectivity was examined of reactions between nine 3(5)-aminopyrazoles and 2-acetylcyclopentanone and 2-acetylcyclohexanone under various conditions. A series of cyclopenta[e]pyrazolo-[1,5-a]pyrimidines was obtained. The highest regioselectivity of the reaction was observed in alcohol at 20°C in the presence of a catalytic quantity of trifl uoroacetic acid. The regiostructure of compounds was established by 1H and 13C NMR spectroscopy. Pleiades Publishing, Ltd., 2012.

Novel potent neuropeptide Y Y5 receptor antagonists: Synthesis and structure-activity relationships of phenylpiperazine derivatives

A series of phenylpiperazine derivatives were synthesized and evaluated for their neuropeptide Y (NPY) Y5 receptor antagonistic activities. The benzindane portion of 2 was replaced by 1-phenylpiperazine, resulting in novel urea derivative 3f. Subsequent optimization of the phenylpiperazine template by substitution of the phenyl moiety resulted in a series of (2-methanesulfonamidephenyl)piperazine derivatives that showed potent binding affinity and antagonistic activity for the Y5 receptor.