151387-00-7

Basic information

• Product Name: 2,4-DICHLOROQUINOLIN-3-CARBOXALDEHYDE
• Synonyms: 2,4-DICHLOROQUINOLIN-3-CARBOXALDEHYDE;2,4-Dichloroquinoline-3-carboxaldehyde;2,4-dichloroquinoline-3-carbaldehyde
• CAS NO: 151387-00-7
• Molecular Formula: C₁₀H₅Cl₂NO
• Molecular Weight: 226.06
• Mol File: 151387-00-7.mol

Chemical Properties

• Appearance: /
• Refractive Index: 1.697
• CAS DataBase Reference: 2,4-DICHLOROQUINOLIN-3-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLOROQUINOLIN-3-CARBOXALDEHYDE(151387-00-7)
• EPA Substance Registry System: 2,4-DICHLOROQUINOLIN-3-CARBOXALDEHYDE(151387-00-7)

Safety Data

• Hazardous Substances Data: 151387-00-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2,4-Dichloroquinolin-3-carboxaldehyde is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows for the development of new compounds with potential therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 2,4-dichloroquinolin-3-carboxaldehyde serves as a key intermediate in the production of pesticides and other crop protection agents. Its chemical properties enable the creation of effective and targeted agrochemicals.
Used in Material Science:
2,4-Dichloroquinolin-3-carboxaldehyde is utilized in material science for the development of new materials. Its structural components make it a valuable component in the synthesis of materials with specific properties for various applications.
Used in Chemical Reactions:
2,4-DICHLOROQUINOLIN-3-CARBOXALDEHYDE is also used as a reactant in various chemical reactions, contributing to the synthesis of a wide range of organic and inorganic compounds, further expanding its utility in chemical research and development.

InChI:InChI=1/C10H5Cl2NO/c11-9-6-3-1-2-4-8(6)13-10(12)7(9)5-14/h1-5H

Upstream product

• 1076-59-1 3-phenyl-4H-isoxazol-5-one 
• 68-12-2 N,N-dimethyl-formamide 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 62-53-3 aniline 
• 703-61-7 2,4-dichloroquinoline 

Downstream Products

• 703-61-7 2,4-dichloroquinoline 

Relevant articles and documents

2-Bromo-4-chlorofuran[2,3-b]quinoline, derivatives thereof, their synthetic methods and application

The invention discloses a full-synthetic method of 2-bromo-4-chlorofuran[2,3-b]quinoline, derivatives of 2-bromo-4-chlorofuran[2,3-b]quinoline, and synthetic method and application of the derivatives.The preparation methods applied herein have mild reaction conditions; reagents used herein are low in toxicity; the raw materials are low in price and easy to attain; after-treatment is convenient; massive enrichment is available. Pharmacological experiments show that most of the compounds herein have good antitumor activity and high stability and are expectedly developable into antitumor drugs.

Synthesis of novel isoxazole fused heterocycles

Condensation of 3-aryl-4-formyl isoxazoles with 1,2-diamines led to the formation of 3-aryl-(6,7-benzo-1,5-heptadiazino)(3,2-d)-isoxazoles or isoxazolo-[5,4-b]-benzodiazepines and 3,10-diaryl-6,7,14,15-tetrhydro-13 H,16H-diisoxazole-(4,5-b;4,5-l)(1,4,8,11)-tetra-aza-cyclo-tetra-deca-4, 14-diones, the novel seven-and 14-membered heterocyclic systems. Similar compounds are of great importance in medicinal chemistry.

Imidazole based kinase inhibitors

The present invention provides compounds having Formula I and their use for the treatment of cancer.

A convenient synthesis of 8,9,10,11-tetrahydrodibenzo[b,h] [1,6]naphthyridin-6(5H)ones

Substituted 8,9,10,11-tetrahydrodibenzo[b,h][1,6]naphthyridin-6(5H)ones (5) have been synthesized by the condensation of 4-amino-3-formylquinolin-2(1H)ones (4) with cyclohexanone in presence of acetic acid and sulphuric acid. The precusors have been obtained by the animation of 4-chloro-3-formylquinolin-2(1H)ones (3).

A novel rearrangement of 3-arylisoxazol-5(4H)-ones: One-pot synthesis of new 2,4-dichloroquinoline-3-carbaldehydes

Vilsmeier-Haack reaction, using a specific combination of phosphorus oxychloride and dimethylformamide, on 3-arylisoxazol-5(4H)ones 1 resulted in 2,4-dichloroquinoline-3-carbaldehydes 6 as the major products along with other minor products, through a novel rearrangement. Oxidation of 6 with alkaline potassium permanganate gave 2,4-dichloroquinoline-3-carboxylic acids 7. Decarboxylation of 6 and decarboxylation of 7 using aqueous sodium hydroxide yielded 2,4-dichloroquinolines 8. All the compounds were characterised by elemental and spectral analysis.