- Synthesis of N′-arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazides as antidepressants
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Abstract: A series of N′-arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazide were synthesized. Condensation of aromatic aldehydes with 2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazide gave corresponding N′ -arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazide. Spectral and elemental analysis was used for structural elucidation of novel 1, 2, 4-triazole schiff bases. The newly synthesized compounds were screened for their antidepressant activity by using tail suspension test in mice. Compound 4l showed significant activity among the series. Graphical Abstract: A series of new N′-arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio)acetohydrazide have been synthesized and characterized. The results revealed that compound 4l with bromo substitution exhibited promising antidepressant activity among the series. [InlineMediaObject not available: see fulltext.].
- Chelamalla, Radhika,Akena, Venkatesham,Manda, Sarangapani
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- Structure of reaction products of substituted [1,3]thiazolo[3,2-b][1,2,4] triazol-6(5H)-ones with amines and hydrazines
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Reactions of 2-(4-methylphenyl)[1,3]triazolo[3,2-b][1,2,4]thiazol-6(5H)-one and 5-benzylidene-2-(4- methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)- one with amines and hydrazines of diverse structures were studied. The structure of the reaction pro
- Rzhevskii,Gerasimova,Chirkova,Filimonov,Firgang,Stashina,Suponitsky
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p. 1680 - 1685
(2014/02/14)
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