391-92-4

Basic information

• Product Name: METHYL 5-FLUORO-2-HYDROXYBENZOATE
• Synonyms: 5-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER;Methyl 5-fluoro-2-hydroxybenzoate,97%;4-Fluoro-2-(methoxycarbonyl)phenol;Methyl 5-fluoro-2-hydroxybenzoate, 97% 5GR;4-Fluoro-2-(methoxycarbonyl)phenol, Methyl 5-fluorosalicylate;Methyl 5-fluoro-2-hydroxybenzoate 98%;Methyl5-fluoro-2-hydroxybenzoate98%
• CAS NO: 391-92-4
• Molecular Formula: C₈H₇FO₃
• Molecular Weight: 170.1383
• Product Categories: Benzoic acid;C8 to C9;Carbonyl Compounds;Esters
• Mol File: 391-92-4.mol
• Article Data: 23

Chemical Properties

• Melting Point: 30-34
• Boiling Point: 50/0.15mm
• Flash Point: 105
• Appearance: Pale yellow/Low Melting Solid
• Density: 1.309g/cm³
• Vapor Pressure: 0.0265mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.77±0.18(Predicted)
• CAS DataBase Reference: METHYL 5-FLUORO-2-HYDROXYBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-FLUORO-2-HYDROXYBENZOATE(391-92-4)
• EPA Substance Registry System: METHYL 5-FLUORO-2-HYDROXYBENZOATE(391-92-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 391-92-4(Hazardous Substances Data)

Usage

Synthesis

Methyl 5-fluoro-2-hydroxybenzoate is synthesized by esterification of 5-fluorosalicylic acid with methanol.

Chemical Properties

Pale yellow low melting solid

Uses

Methyl 5-fluoro-2-hydroxybenzoate can be used as pharmaceutical intermediates and organic synthesis intermediates, for laboratory research.

InChI:InChI=1/C8H7FO3/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4,10H,1H3

Upstream product

• 67-56-1 methanol 
• 345-16-4 5-fluoro-2-hydroxybenzoic acid 
• 119-36-8 methyl salicylate 
• 124-41-4 sodium methylate 
• 149-73-5 trimethyl orthoformate 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 403-33-8 methyl 4-flurobenzoate 
• 455-68-5 methyl 3-fluorobenzoate 
• 74-88-4 methyl iodide 
• 75-36-5 acetyl chloride 

Downstream Products

• 796851-83-7 methyl-5-fluoro-2-(ethoxy-2-oxoethoxy)benzoate 
• 928264-54-4 methyl 5-fluoro-2-[((trifluoromethyl)sulfonyl)oxy]benzoate 
• 2357-33-7 5-fluoro-2-hydroxy-benzyl alcohol 
• 934753-21-6 Methyl 5-fluoro-2-{[2-(trifluoromethyl)benzyl]oxy}benzoate 
• 934753-30-7 methyl 2-(4-tert-butylbenzyloxy)-5-fluorobenzoate 
• 934753-18-1 2-(2-chlorobenzyloxy)-5-fluorobenzoic acid 
• 1351763-23-9 5-fluoro-2-(pyridin-2-ylmethoxy)benzoic acid 
• 4068-73-9 methyl 3-bromo-5-fluoro-2-hydroxybenzoate 
• 1247810-91-8 methyl 4-fluoro-[1,1'-biphenyl]-2-carboxylate 
• 1408282-26-7 6-fluoro-3,10-diazatricyclo[6.4.1.0^4,13]trideca-1,4⁽¹³⁾,5,7-tetraen-9-one 
• 80568-44-1 2-mercapto-4-methoxybenzoic acid 

Relevant articles and documents

Rhodium(III)-Catalyzed Oxidative Intramolecular 1,1-Oxyamination of Alkenes with Protected Amino Acids to Produce Oxazoloisoindole-2,5-diones

It has been established that an electron-deficient bis(ethoxycarbonyl)-substituted cyclopentadienyl (CpE) rhodium(III) complex catalyzes the oxidative intramolecular 1,1-oxyamination of alkenes with N-benzoyl amino acids to produce oxazoloisoindole-2,5-diones. Experimental and theoretical mechanistic studies revealed that this oxidative 1,1-oxyamination proceeds via not the aza-Wacker reaction but the formation of a rhoda(III)oxazolidine initiated by the carboxylic acid-directed N?H bond cleavage.

ASK1 INHIBITING AGENTS

Provided are compounds of Formulas (I'), (I), (II') and (II), or pharmaceutically acceptable salts thereof, and methods for their use and production.

NEW ANTIBACTERIAL COMPOUNDS

The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.