394-04-7

Basic information

• Product Name: 5-FLUORO-2-METHOXYBENZOIC ACID
• Synonyms: 5-FLUORO-2-METHOXYBENZOIC ACID;BUTTPARK 32\01-79;RARECHEM AL BO 1468;5-Fluoro-2-Methoxybenzoic acid, JRD, 97%;5-Fluoro-o-anisic acid, 2-Carboxy-4-fluoroanisole;5-FLUORO-2-METHOXYBENZOIC;5-Fluoro-2-Methoxylbenzoic acid;Benzoic acid,5-fluoro-2-Methoxy-
• CAS NO: 394-04-7
• Molecular Formula: C₈H₇FO₃
• Molecular Weight: 170.14
• EINECS: 1312995-182-4
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Acids & Esters;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Aromatic Amino Acids;Peptide Synthesis;Unnatural Amino Acid Derivatives;Fluorine series
• Mol File: 394-04-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 87-91 °C(lit.)
• Boiling Point: 294 °C at 760 mmHg
• Flash Point: 131.6 °C
• Appearance: /
• Density: 1.307 g/cm³
• Vapor Pressure: 0.000757mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.75±0.10(Predicted)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 5-FLUORO-2-METHOXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-2-METHOXYBENZOIC ACID(394-04-7)
• EPA Substance Registry System: 5-FLUORO-2-METHOXYBENZOIC ACID(394-04-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 394-04-7(Hazardous Substances Data)

Usage

Chemical Properties

off-white powder

Uses

5-Fluoro-3-hydroxy-2-methylbenzoic acid 1 was synthesized from 5-fluoro-2-methylbenzoic acid by nitration, reduction, diazotization and hydrolysis. Another methylcarbamoyl-substituted benzylamine 12 was synthesized from 5-fluoro-2-methylbenzoic acid via the sequential bromination,azido replacement and the reduction.

InChI:InChI=1/C8H7FO3/c1-12-7-3-2-5(9)4-6(7)8(10)11/h2-4H,1H3,(H,10,11)

Upstream product

• 345-16-4 5-fluoro-2-hydroxybenzoic acid 
• 151793-20-3 methyl 5-fluoro-2-methoxybenzoate 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 452-72-2 4-fluoro-2-methylphenol 
• 452-71-1 4-fluor-2-methylaniline 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 60-29-7 diethyl ether 
• 124-38-9 carbon dioxide 
• 917-54-4 methyllithium 
• 109-72-8 n-butyllithium 
• 399-54-2 4-fluoro-2-methylanisole 
• 445-82-9 1-(5-fluoro-2-methoxyphenyl)ethanone 

Downstream Products

• 1335036-66-2 N-(8-(tetrahydrofuran-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3β-yl)-5-fluoro-2-methoxybenzamide 
• 1335036-49-1 N-(8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3β-yl)-5-fluoro-2-methoxybenzamide 
• 1335556-10-9 C₂₈H₃₀FNO₃ 
• 1335557-73-7 C₅₄H₆₉FN₄O₉Si 
• 1335557-72-6 C₅₃H₆₇FN₄O₉Si 
• 1335557-71-5 C₄₅H₄₉FN₄O₇ 
• 1335557-70-4 C₅₆H₇₁FN₄O₉Si 
• 1335557-69-1 C₃₆H₄₃FN₂O₅ 
• 1335557-68-0 C₃₆H₄₄ClFN₂O₅ 
• 1335557-67-9 C₃₆H₄₅FN₂O₆ 
• 1335557-66-8 C₃₃H₄₁FN₂O₆ 
• 1254339-82-6 C₂₇H₂₆FNO₆ 
• 1254339-80-4 C₃₁H₃₄FNO₇ 
• 1335557-63-5 C₆₉H₇₇FN₄O₉Si 

Relevant articles and documents

INHIBITORS OF THE MENIN-MLL INTERACTION

The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.