15185-01-0

Basic information

• Product Name: N-BUTYLPYRROLIDINE
• Synonyms: 1-TERT-BUTYL-PYRROLIDINE;Pyrrolidine, 1-(1,1-diMethylethyl)-
• CAS NO: 15185-01-0
• Molecular Formula: C₈H₁₇N
• Molecular Weight: 127.22728
• Mol File: 15185-01-0.mol

Chemical Properties

• Boiling Point: 140.8 °C at 760 mmHg
• Flash Point: 32.7 °C
• Appearance: /
• Density: 0.871 g/cm³
• Vapor Pressure: 6.02mmHg at 25°C
• Refractive Index: 1.462
• CAS DataBase Reference: N-BUTYLPYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BUTYLPYRROLIDINE(15185-01-0)
• EPA Substance Registry System: N-BUTYLPYRROLIDINE(15185-01-0)

Safety Data

• Hazardous Substances Data: 15185-01-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-BUTYLPYRROLIDINE is used as a solvent for its ability to dissolve a wide range of substances, which is crucial in the formulation of pharmaceutical products.
Used in Agrochemical Industry:
N-BUTYLPYRROLIDINE is used as a solvent to facilitate the dissolution of active ingredients in agrochemical formulations, enhancing their effectiveness and application.
Used in Coatings Industry:
N-BUTYLPYRROLIDINE is used as a solvent to improve the solubility and application of coating materials, contributing to better performance and durability of the coatings.
Used as a Corrosion Inhibitor:
N-BUTYLPYRROLIDINE is used to protect metal surfaces from corrosion, extending the lifespan and maintaining the integrity of materials in various applications.
Used as a Reaction Medium in Organic Synthesis:
N-BUTYLPYRROLIDINE serves as a medium for various organic reactions, providing a suitable environment for chemical processes to occur efficiently.

InChI:InChI=1/C8H17N/c1-8(2,3)9-6-4-5-7-9/h4-7H2,1-3H3

Upstream product

• 75-64-9 tert-butylamine 
• 110-56-5 1,4-dichlorobutane 
• 110-52-1 1,4-dibromo-butane 

Downstream Products

• 607-68-1 2,4-dichloroquinazoline 
• 292857-23-9 (-)-(4S,5R,2'S)-4-(1'-tert-butylpyrrolidin-2'-yl)-5-menthyloxy-4,5-dihydrofuran-2(3H)-one 
• 292857-34-2 (-)-(4S,5R,2'R)-4-(1'-tert-butylpyrrolidin-2'-yl)-5-menthyloxy-4,5-dihydrofuran-2(3H)-one 

Relevant articles and documents

Hydrogen abstraction from cyclic amines by the cumyloxyl and benzyloxyl radicals. the role of stereoelectronic effects and of substrate/radical hydrogen bonding

A kinetic study on the hydrogen abstraction reactions from cyclic amines and diamines (pyrrolidines, piperidines, morpholines, and piperazines) by the cumyloxyl (CumO?) and benzyloxyl (BnO?) radicals was carried out. The reactions with CumO? were described in all cases as direct hydrogen abstractions. The differences in the hydrogen abstraction rate constant (kH) were explained in terms of the different number of abstractable hydrogen atoms, the operation of stereoelectronic effects, and, with the morpholines, on the basis of polar effects. Significantly higher kH values were measured for the reactions of the amines with BnO?. This behavior was explained on the basis of a mechanism that proceeds through the rate-determining formation of a hydrogen bonded pre-reaction complex between the radical α-C-H and the nitrogen lone pair followed by hydrogen abstraction within the complex. A decrease in kH was observed going from secondary to tertiary amines and, with tertiary amines, on increasing steric hindrance at nitrogen, pointing toward the important role of steric and electronic effects on pre-reaction complex formation. These results expand previous findings contributing to a detailed mechanistic description of the reactions of alkoxyl radicals with amines, showing that structural effects in both the substrate and the radical can play a dramatic role and providing new information on the role of substrate/radical interactions on these processes.

Highly efficient and stereoselective radical addition of tertiary amines to electron-deficient alkenes - Application to the enantioselective synthesis of necine bases

A convenient and highly efficient method for the regio- and stereoselective addition of tertiary amines to electron-deficient alkenes has been elaborated. It is based on a radical chain reaction of α-aminyl radicals with alkenes, induced by a photoelectro