15200-13-2

Basic information

• Product Name: 6-ethoxy-2,3,4,5-tetrahydropyridine
• Synonyms: 6-ethoxy-2,3,4,5-tetrahydropyridine;2-ethoxy-3,4,5,6-tetrahydropyridine
• CAS NO: 15200-13-2
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.18
• Mol File: 15200-13-2.mol

Chemical Properties

• Boiling Point: 170.539 °C at 760 mmHg
• Flash Point: 47.569 °C
• Appearance: Light yellow liquid
• Density: 1.003 g/cm³
• Vapor Pressure: 1.941mmHg at 25°C
• Refractive Index: 1.488
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.80±0.20(Predicted)
• CAS DataBase Reference: 6-ethoxy-2,3,4,5-tetrahydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-ethoxy-2,3,4,5-tetrahydropyridine(15200-13-2)
• EPA Substance Registry System: 6-ethoxy-2,3,4,5-tetrahydropyridine(15200-13-2)

Safety Data

• Hazardous Substances Data: 15200-13-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
6-ethoxy-2,3,4,5-tetrahydropyridine is utilized as a key intermediate in the organic synthesis of a range of pharmaceuticals and agrochemicals. Its unique structure allows for the development of new compounds with specific therapeutic or pesticidal properties, contributing to advancements in medicine and agriculture.
Used in Neurological Research:
As a compound with neurotoxic effects, 6-ethoxy-2,3,4,5-tetrahydropyridine is employed as a model for Parkinson's disease research. It can induce degeneration of dopaminergic neurons in the brain, providing valuable insights into the mechanisms of neurodegeneration and aiding in the development of potential therapeutic interventions for Parkinson's disease.
Used in Catalysis:
6-ethoxy-2,3,4,5-tetrahydropyridine also serves as a ligand in the synthesis of metal complexes, which are applied in various catalytic processes. Its ability to coordinate with metal ions enhances the catalytic activity and selectivity of these complexes, making it a useful component in the design of efficient catalysts for chemical reactions.

InChI:InChI=1/C7H13NO/c1-2-9-7-5-3-4-6-8-7/h2-6H2,1H3

Upstream product

• 675-20-7 piperidin-2-one 
• 1192-28-5 Cyclopentanone oxime 
• 120-92-3 cyclopentanone 
• 368-39-8 triethyloxonium fluoroborate 
• 64-67-5 diethyl sulfate 

Downstream Products

• 2446-62-0 7,8,9-trihydropyrido[2,1-b]quinazolin-11(6H)-one 
• 108140-09-6 3-Oxo-3-phenyl-2-piperidin-(2E)-ylidene-propionic acid ethyl ester 
• 143602-44-2 2-{(E)-4-[2-Ethylamino-5-(4-nitro-phenyl)-thiazol-4-yl]-butylimino}-piperidine; hydrobromide 
• 4802-79-3 1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)quinolizine 
• 38199-31-4 1-(2-Indol-3-ylethyl)piperidin-2-one 

Relevant articles and documents

Modular routes towards new N,O-bidentate ligands containing an electronically delocalised β-enaminone chelating backbone

Polyketones are synthesised by a transition-metal-catalysed copolymerisation of olefins and carbon monoxide. Nickel complexes with N,O-chelating ligands turned out to be promising catalysts in that field. In this work a series of new N,O ligands with an electronically delocalised β-enaminone backbone were synthesised and fully characterised. The ligand design was inspired by the ligand found in the most efficient nickel catalyst for polyketone synthesis and developed to a highly modular LEGO-like arsenal of reactions to versatile substituted β-enaminone ligands. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.