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Cyclopentanone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 120-92-3 Structure
  • Basic information

    1. Product Name: Cyclopentanone
    2. Synonyms: Adipinketon;Dumasin;Pyran-2,4(3H)-dione, 3-acetyl-6-methyl-;ADIPIC KETONE;AKOS BBS-00004293;KETOCYCLOPENTANE;KETOPENTAMETHYLENE;CYCLOPENTANONE
    3. CAS NO:120-92-3
    4. Molecular Formula: C5H8O
    5. Molecular Weight: 84.12
    6. EINECS: 204-435-9
    7. Product Categories: Pharmaceutical Intermediates;Organics;Alpha Sort;C;Volatiles/ Semivolatiles;C3 to C6;Carbonyl Compounds;Ketones;Alphabetical Listings;C-D;Flavors and Fragrances
    8. Mol File: 120-92-3.mol
    9. Article Data: 487
  • Chemical Properties

    1. Melting Point: -51 °C
    2. Boiling Point: 130-131 °C(lit.)
    3. Flash Point: 87 °F
    4. Appearance: Clear colorless to slightly yellow/Liquid
    5. Density: 0.951 g/mL at 25 °C(lit.)
    6. Vapor Density: 2.97 (vs air)
    7. Vapor Pressure: 9.7mmHg at 25°C
    8. Refractive Index: n20/D 1.437(lit.)
    9. Storage Temp.: Flammables area
    10. Solubility: 9.18g/l slightly soluble
    11. Explosive Limit: 1.6-10.8%(V)
    12. Water Solubility: PRACTICALLY INSOLUBLE
    13. Stability: Stable. Incompatible with strong reducing agents, strong oxidizing agents, strong bases.
    14. Merck: 14,2743
    15. BRN: 605573
    16. CAS DataBase Reference: Cyclopentanone(CAS DataBase Reference)
    17. NIST Chemistry Reference: Cyclopentanone(120-92-3)
    18. EPA Substance Registry System: Cyclopentanone(120-92-3)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 10-36/38
    3. Safety Statements: 23
    4. RIDADR: UN 2245 3/PG 3
    5. WGK Germany: 1
    6. RTECS: GY4725000
    7. TSCA: Yes
    8. HazardClass: 3
    9. PackingGroup: III
    10. Hazardous Substances Data: 120-92-3(Hazardous Substances Data)

120-92-3 Usage

Physical and Chemical Properties

Cyclopentanone is also known Adipic Ketono. It is transparent colorless oily liquid. It has smell of special ether and also slightly mint-smell. It has a relative molecular mass being 84.12. It also has a relative density being 0.9487, melting point being-51.3 ℃, boiling point being 130.6 ℃, 23~24 ℃ (1.333 X 103Pa), the refractive index being 1.4366, and the flash point being 30 ℃. It is insoluble in water, soluble in alcohol, ether and acetone. It is narcotic at high concentrations. It can be obtained through oxidation of cyclopentanol. It can also be obtained through the heating of Adipic acid in the presence of Barium hydroxide. Cyclopentanone is also easily subject to polymerization especially in the presence of an acid. In the case of heating, it can participate in the following dehydration reactions, respectively producing 2-cyclopentylene cyclopentanone and 2'-cyclopentylene-2-cyclopentylene cyclopentanone: Hydrogenation can produce double-cyclopentanol with further dehydration producing 2, 2-tetramethylene cyclopentanone. Cyclopentanone is mainly used for the manufacturing of drugs, biological agents, pesticides and rubber additives. Aldehydes, ketones can react with diazoalkane and have the nitrogen atoms lost, generating two carbonyl compounds and epoxy compounds. When the aldehydes, ketones molecules contain electron-withdrawing groups, the reactivity is increased will boost the generation of the epoxy compound. The ketone molecule, with the increase of the hydrocarbon group, also mainly generates epoxy compound. Cyclic ketones, instead, will have ring expansion reactions. The bigger the hydrocarbyl group of the diazoalkane is, the more carbonyl compounds can be obtained. The order of the ketone reactivity is consistent with its nucleophilic substitution order: Cl3CCOCH3> ClCH2COCH3> CH3COCH3> CH3COC6H5> cyclohexanone> cyclopentanone> cycloheptanone> cyclooctanone.

The main purpose

1, Take the n-valeraldehyde and cyclopentanone as raw material, and first go through aldol condensation reaction and further dehydration reaction to obtain pentylene cyclopentanone, then followed by selective catalytic hydrogenation to obtain pentyl cyclopentanone. Pentyl cyclopentanone has strong floral and fruity aroma as well as nuances of jasmine. It can be used in the formulation of daily chemical flavor with the usage amount being less than 20%. IFRA has no restrictions. 2, Take n-hexanal and cyclopentanone as the raw material, first have condensation, and then perform selective hydrogenation reaction to obtain hexyl cyclopentanone. Hexyl cyclopentanone has strong jasmine smell accompanied by fruit nuances and can be used in perfume fragrance as well as the formulation of other kinds of fragrance with the usage amount being less than 5%. IFRA has no restrictions. 3, Take the 1-pentene or 1-heptene obtained by the cracking of paraffin or dehydration of the corresponding alcohol as the raw material, in the presence of t-butyl peroxide as the initiator, have addition reaction of the free radical group with cyclopentanone, generating 2-pentyl cyclopentanone (or 2-heptyl-cyclopentanone) with oxidation and ring expansion reaction to become δ-lactone (or δ-Dodecalactone). 4 Synthesis route with cyclopentanone being the starting material is of the greatest industrial production value. Cyclopentanone is first had aldol condensation reaction with n-valeraldehyde with the dehydration products further undergoing condensation and the selective hydrogenation to generate 2-pentyl cyclopentanone. It finally undergoes oxidation and ring expansion to become δ-decalactone. 5, δ-decalactone is mainly used in the formulation of edible food flavor. It is considered with the characteristic flavor of the natural cream. Before its emergence, perfumers had long been limited to application of monomer spices such as butanedione and vanillin monomers to be as the major raw material for the deployment of butter flavor. But it is generally recognized that the formulated butter flavor is worse than natural products in the respects of both taste or flavor respects. Only after the use of δ-decalactone can it have realistic cream flavor, especially in the case of using δ-Dodecalactone and δ-decalactone in combination for being as the main flavor raw material which can further improve the flavor and effect of the formulated cream spice. 6, Take cyclopentanone and pentanal as raw materials, have condensation to produce 2-(1-hydroxy) pentyl cyclopentanone which is then reacted with dimethyl malonate and hydrolyzed at 160~180 ℃, go through decarboxylation, esterification to obtain methyl dihydrojasmonate. Methyl dihydrojasmonate is the edible flavor provided by the GB2760-1996 of China for temporary application. Its aroma is better than the natural methyl jasmonate. Its property is also relatively stable. The above information is edited by the lookchem of Dai Xiongfeng.

Chemical Properties

Different sources of media describe the Chemical Properties of 120-92-3 differently. You can refer to the following data:
1. It is colorless, oily liquid with a pleasant mint smell. It has a melting point of-58.2 ℃, boiling point of 130.6 ℃, the relative density of 0.9509 (20 ℃), the refractive index of 1.4366 and the flash point of 29.82 ℃. It is miscible with ethanol, ethyl ether and slightly soluble in water. It is easy to undergo polymerization, especially in the case of trace amount of acid.
2. colourless liquid
3. Cyclopentanone has an agreeable, peppermint-like odor. It tends to polymerize in the presence of acids.

Production method

It can be obtained through the heating of Adipic acid in the presence of barium hydroxide. Mix the barium hydroxide and adipic acid uniformly and heat to 285-295 °C, further distill out the generated cyclopentanone at this temperature. The distilled calcium chloride is salted out for separating the cyclopentanone; add appropriate amount of alkaline solution to remove the adipic acid wash, then wash with water; dry with anhydrous calcium chloride; have distillation; collect the fraction in the 128-131 ℃ to obtain the finished product with the yield being 75-80%.

Category

Flammable liquid

Toxicity grading

poisoning

Acute toxicity

Intraperitoneal-mouse LD50: 1950 mg/kg; subcutaneous-Mouse LD50: 2600 mg/kg.

Data irritation

Skin-rabbit 500 mg Mild; Eyes-rabbit 100 mg severe.

Flammability and hazard characteristics

It is flammable in case of fire, high temperature and with burning producing irritated smoke.

Storage characteristics

Treasury: ventilation, low-temperature and dry; store it separately from oxidants and acids.

Occurrence

Reported found in roasted onion, baked potato, tomato, gruyere cheese, butter, heated chicken, boiled beef, heated pork, roasted pecan, yellow passion fruit juice.

Uses

Cyclopentanone is used as an intermediate in the synthesis of rubber adhesives, synthetic resins, pharmaceuticals and biologically active compounds. It acts as precursor for the preparation of cyclopentamine and also pentethylcyclanone, cyclopentobarbital. It is a useful laboratory reagent and is used as thinner for epoxies. It can also be used as a solvent in paint and varnish removers and for electronic applications. As a dry cleaning agent, it is used for oil extraction. It is also involved in the preparation of cyclopentanone derivatives like cyclopenylamine and cyclopentanol which find application in the perfume industry.

Preparation

Prepared by heating adipic acid (285 to 295°C) in the presence of barium hydroxide, distilling, ether extraction and then fractionation.

Definition

ChEBI: A cyclic ketone that consists of cyclopentane bearing a single oxo substituent.

Aroma threshold values

Aroma characteristics at 2.0%: musty, slightly toasted bitter almondlike nutty, solventlike with a powdery nuance.

Taste threshold values

Taste characteristics at 20 ppm: musty, toasted nutty with a slight meaty nuance.

General Description

A clear colorless liquid with a petroleum-like odor. Flash point 87°F. Less dense than water and insoluble in water. Vapors heavier than air.

Air & Water Reactions

Highly flammable. Insoluble in water.

Reactivity Profile

Cyclopentanone polymerizes easily, especially in the presence of acids. Can react with oxidizing materials, i.e. hydrogen peroxide.

Health Hazard

Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Safety Profile

Moderately toxic by intraperitoneal and subcutaneous routes. A skin and severe eye irritant. Dangerous fire hazard when exposed to heat or flame; can react with oxidizers. To fight fire, use alcohol foam, foam, CO2, dry chemical. Potentially explosive reaction with hydrogen peroxide + nitric acid. When heated to decomposition it emits acrid smoke and fumes. See also KETONES.

Purification Methods

Shake it with aqueous KMnO4 to remove materials absorbing around 230 to 240nm. Dry it with Linde-type 13X molecular sieves and fractionally distil it. It has also been purified by conversion to the NaHSO3 adduct which, after crystallising four times from EtOH/water (4:1), is decomposed by adding to an equal weight of Na2CO3 in hot H2O. The free cyclopentanone is steam distilled from the solution. The distillate is saturated with NaCl and extracted with *benzene which is then dried (anhydrous K2CO3) and evaporated. The residue is then distilled [Allen, et al. J Chem Soc 1909 1960]. [Beilstein 7 IV 5.]

Check Digit Verification of cas no

The CAS Registry Mumber 120-92-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 120-92:
(5*1)+(4*2)+(3*0)+(2*9)+(1*2)=33
33 % 10 = 3
So 120-92-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H8O/c6-5-3-1-2-4-5/h1-4H2

120-92-3 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A14222)  Cyclopentanone, 99%   

  • 120-92-3

  • 250ml

  • 251.0CNY

  • Detail
  • Alfa Aesar

  • (A14222)  Cyclopentanone, 99%   

  • 120-92-3

  • 500ml

  • 474.0CNY

  • Detail
  • Alfa Aesar

  • (A14222)  Cyclopentanone, 99%   

  • 120-92-3

  • 2500ml

  • 1883.0CNY

  • Detail

120-92-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name cyclopentanone

1.2 Other means of identification

Product number -
Other names Adipic keyone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120-92-3 SDS

120-92-3Synthetic route

Cyclopentanol
96-41-3

Cyclopentanol

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With water; nickel dibromide; dibenzoyl peroxide In N,N-dimethyl acetamide at 60℃; for 3h;100%
With Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H2O) In hexane for 20h; Solvent; Reflux;100%
With allyl methyl carbonate; dihydridotetrakis(triphenylphosphine)ruthenium In toluene at 100℃; for 13h;99%
cyclopentene
142-29-0

cyclopentene

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With oxygen; palladium(II) sulfate; PdSO4-H3PMo6W6O40 In cyclohexane; water at 30℃; for 6h;100%
With oxygen; H3PMo6W6O40 In cyclohexane; water at 29.9℃; under 760 Torr; for 6h;100%
With palladium(II) sulfate; oxygen; H3PMo6W6O40 In cyclohexane; water at 29.9℃; under 760 Torr; for 6h; Product distribution; Rate constant; other time, other Pd(II) salt, other concentration of catalyst;100%
cyclopent-2-enone
930-30-3

cyclopent-2-enone

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With limonene.; palladium on activated charcoal for 0.5h; Heating;100%
With hydrogen; SC-1 Ni2B In methanol at 25℃; under 760 Torr; for 24h;100%
With diphenylsilane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) In chloroform for 0.5h; Ambient temperature;99%
Cyclopentanone oxime
1192-28-5

Cyclopentanone oxime

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With bis(1-CH2Ph-3,5,7-3N-1-N(1+)tricyclo[3.3.1.13,7]decaneS2O8 In acetonitrile for 0.0583333h; Oxidation; Heating;100%
With potassium permanganate In water; acetonitrile at 25℃; for 1h;96%
With dihydrogen peroxide; tripropylammonium fluorochromate (VI) In acetone at 0 - 10℃; for 2.5h;96%
Sodium; 6-cyclopentylideneamino-hexanoate

Sodium; 6-cyclopentylideneamino-hexanoate

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With hydrogenchloride for 0.0416667h; Product distribution; Ambient temperature; pH = 4-6, regeneration of aldehyde;100%
Cyclopentyl bromide
137-43-9

Cyclopentyl bromide

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With oxygen; kieselguhr; copper(l) chloride In hexane for 2.5h; Oxidation; Heating;99%
1,1-Bis(phenylthio)cyclopentane
85895-34-7

1,1-Bis(phenylthio)cyclopentane

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile at 20 - 25℃; for 2h; Irradiation;98%
furfural
98-01-1

furfural

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With hydrogen In water at 160℃; under 30003 Torr; for 7h; Automated synthesizer;98%
With hydrogen In water at 160℃; under 30003 Torr; for 2.5h; Reagent/catalyst; Temperature; Pressure; Autoclave;96%
With hydrogen In water at 150℃; under 30003 Torr; for 6h; Reagent/catalyst; Autoclave;95%
Cyclopentane
287-92-3

Cyclopentane

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With hydrogenchloride; FeH6Mo6O24(3-)*3H3N*3H(1+)*7H2O; tetrabutylammomium bromide; dihydrogen peroxide In 1,4-dioxane; water at 85℃; for 24h;96%
With [Fe4III(μ-O)2(μ-acetate)6(2,2'-bipyridine)2(H2O)2](NO3-)(OH-); dihydrogen peroxide; acetic acid In water; acetonitrile at 32℃; for 3h; Catalytic behavior;60%
With dihydrogen peroxide; vanadium phosphorus oxide In acetonitrile at 50℃; for 20h;48%
nitrocyclopentane
2562-38-1

nitrocyclopentane

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With sodium perborate at 70℃; for 3h; Ionic liquid;95%
With bis-trimethylsilanyl peroxide; sodium hydride In tetrahydrofuran at 20℃; for 24h; Hydrolysis;65%
1-Methanesulfonyl-1-methylsulfanyl-cyclopentane
78795-44-5

1-Methanesulfonyl-1-methylsulfanyl-cyclopentane

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With hydrogenchloride In methanol for 3h; Heating;94%
1-oxa-4-thia-spiro[4.4]nonane
176-38-5

1-oxa-4-thia-spiro[4.4]nonane

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With Glyoxilic acid; Amberlyst 15 for 0.05h; microwave irradiation;94%
With potassium superoxide; tetraethylammonium bromide In N,N-dimethyl-formamide at 20℃; for 3h;88%
Adipic acid
124-04-9

Adipic acid

6-Hydroxyhexanoic acid
1191-25-9

6-Hydroxyhexanoic acid

A

hexahydro-2H-oxepin-2-one
502-44-3

hexahydro-2H-oxepin-2-one

B

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
at 280 - 300℃; Product distribution / selectivity;A 7%
B 94%
sodium phosphate at 290℃; Product distribution / selectivity;A 0.3%
B 77%
tin(IV) oxide at 270℃; Product distribution / selectivity;A 1%
B 73%
sodium hydroxide at 270 - 290℃; Product distribution / selectivity;A 25%
B 58%
sodium borate at 290℃; Product distribution / selectivity;A 0.3%
B 39%
hexanedioic acid dimethyl ester
627-93-0

hexanedioic acid dimethyl ester

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
Al2O3#dotK2O In water at 360℃; under 0.750075 Torr; for 500h;93%
Cyclopentanol
96-41-3

Cyclopentanol

acetic acid
64-19-7

acetic acid

A

cyclopentyl acetate
933-05-1

cyclopentyl acetate

B

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With dihydrogen peroxide; methyltrioxorhenium(VII); sodium bromide for 10h; Ambient temperature;A 8%
B 92%
menthyl alcohol

menthyl alcohol

1-acetoxycyclopentene
933-06-2

1-acetoxycyclopentene

acetic acid mentyl ester

acetic acid mentyl ester

B

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With tetrabutylammonium tricarbonylnitrosylferrate In hexane at 20 - 80℃; Molecular sieve; Inert atmosphere;A 92%
B n/a
4-(1-cyclopenten-1-yl)phenol
877-46-3

4-(1-cyclopenten-1-yl)phenol

A

cyclopentanone
120-92-3

cyclopentanone

B

hydroquinone
123-31-9

hydroquinone

Conditions
ConditionsYield
With hydrogenchloride; dihydrogen peroxide In acetonitrile at 50℃; for 3h; the excess of H2O2 was removed by catalytic hydrogenation using 10percent Pd-C;A n/a
B 91.6%
1-(trimethylsilyloxy)cyclopentene
19980-43-9

1-(trimethylsilyloxy)cyclopentene

A

cyclopent-2-enone
930-30-3

cyclopent-2-enone

B

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With oxygen; palladium matal-containing silica-supported catalyst In various solvent(s) at 59.9℃; for 24h; Product distribution; Mechanism; Pd(0) supported on various zeolites , influence of calcination and reaction temperature and of the solvent;A 90.1%
B n/a
With oxygen; silica gel; palladium In various solvent(s) at 59.9℃; for 24h; Product distribution; solvent;A 90.1%
B 0.8%
With oxygen; silica gel; palladium In various solvent(s) at 59.9℃; for 24h; Yields of byproduct given;A 90.1%
B n/a
With oxygen; silica gel; palladium In various solvent(s) at 59.9℃; for 24h;A 90.1%
B 0.8%
1,4-dioxaspiro[4.4]nonane
176-32-9

1,4-dioxaspiro[4.4]nonane

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With formaldehyd; silica gel; iron(III) chloride at 20℃; for 0.0833333h;90%
With chloral hydrate In hexane at 25℃; for 0.5h; Solvent; Temperature; Inert atmosphere;83%
With boron trifluoride diethyl etherate; sodium iodide In acetonitrile for 2h; Heating;82%
With water; β‐cyclodextrin at 20℃; for 16h;98 % Chromat.
2-cyclopentylidene-1,1-dimethylhydrazine
14090-60-9

2-cyclopentylidene-1,1-dimethylhydrazine

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With cerium(III) chloride; silica gel for 0.0666667h; Microwave irradiation;90%
With sodium perborate; sodium hydroxide; potassium dihydrogenphosphate; water In tert-butyl alcohol at 60℃; for 24h;70%
With ferric nitrate In dichloromethane 30 min., r.t., then reflux;69%
With silica gel In tetrahydrofuran; water at 25℃; for 10h;20%
1-methoxycyclopentene
1072-59-9

1-methoxycyclopentene

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With silica gel; iron(III) chloride at 20℃; for 0.333333h;90%
With sulfuric acid In water at 25℃; Rate constant;
cyclopentanone phenylhydrazone
1132-58-7

cyclopentanone phenylhydrazone

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With zirconium hydrogen sulfate; silica gel In hexane for 1.5h; Heating;90%
bis(η5-cyclopentadienyl)molybdenacyclopentane

bis(η5-cyclopentadienyl)molybdenacyclopentane

A

cyclopentadienylmolybdenum tricarbonyl dimer

cyclopentadienylmolybdenum tricarbonyl dimer

B

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With CO In toluene toluene soln. of Mo complex placed in autoclave under 50 atm CO pressure, stirred at 90°C for 12 h; distn., trapping at -78°C;A 83%
B 90%
(C4H9)3SnOC5H8Br

(C4H9)3SnOC5H8Br

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
decompn. at 150°C for 0.5 h;88%
decompn. at 150°C for 0.5 h;88%
1-(Trimethylsilyloxy)cyclohexene
6651-36-1

1-(Trimethylsilyloxy)cyclohexene

A

cyclohexenone
930-68-7

cyclohexenone

B

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With oxygen; silica gel; palladium In various solvent(s) at 59.9℃; for 24h;A 87.4%
B 0.8%
1-pyrrolidinocyclopent-1-ene
7148-07-4

1-pyrrolidinocyclopent-1-ene

2-((trifluoromethyl)thio)isoindoline-1,3-dione
719-98-2

2-((trifluoromethyl)thio)isoindoline-1,3-dione

A

cyclopentanone
120-92-3

cyclopentanone

B

2-((trifluoromethyl)thio)cyclopentanone

2-((trifluoromethyl)thio)cyclopentanone

Conditions
ConditionsYield
In acetonitrile at 25℃; for 48h; Hydrolysis; trifluoromethylthiolation;A 12.9%
B 87.1%
cyclopentene
142-29-0

cyclopentene

trans-1,2-dibromocyclopentane
10230-26-9

trans-1,2-dibromocyclopentane

B

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With water; oxygen; lithium bromide; copper(ll) bromide In tetrahydrofuran at 25℃; under 760.051 Torr;A 87%
B n/a
Methylenedioxybenzene
274-09-9

Methylenedioxybenzene

A

benzene-1,2-diol
120-80-9

benzene-1,2-diol

B

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With iodo trichloro silane for 1h; Ambient temperature;A 86%
B 39%
Adipic acid
124-04-9

Adipic acid

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With pyrographite at 450℃; for 0.5h;85%
With calcium hydroxide at 350℃; Product distribution; Further Variations:; Reagents;84.2%
at 290℃;
Cyclopentamine
1003-03-8

Cyclopentamine

cyclopentanone
120-92-3

cyclopentanone

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene In dichloromethane at 0 - 20℃; for 0.333333h; Inert atmosphere; Green chemistry;85%
With oxygen; potassium iodide; sodium nitrite In water; acetonitrile for 8h; Reflux;75%
With potassium hydroxide In ethyl acetate at -78℃; Product distribution;18%
2-aminoacetophenone
551-93-9

2-aminoacetophenone

cyclopentanone
120-92-3

cyclopentanone

9-methyl-2,3-dihydro-1H-cyclopenta[b]quinoline
6829-07-8

9-methyl-2,3-dihydro-1H-cyclopenta[b]quinoline

Conditions
ConditionsYield
With 3-methyl-1-sulfoimidazolium trichloroacetate; trichloroacetic acid In neat (no solvent) at 100℃; Friedlaender Quinoline Synthesis;100%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate; N,N-dimethyl-formamide at 90℃; Friedlaender reaction;98%
With ammonium cerium (IV) nitrate In ethanol for 16h; Friedlaender synthesis; Reflux;97%
benzaldehyde
100-52-7

benzaldehyde

cyclopentanone
120-92-3

cyclopentanone

2,5-dibenzylidenecyclopentanone
895-80-7

2,5-dibenzylidenecyclopentanone

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 20℃; Aldol Condensation;100%
With molybdenum(V) chloride In neat (no solvent) for 0.0416667h; Claisen-Schmidt Condensation; Microwave irradiation; Green chemistry;99%
With potassium hydroxide In ethanol at 40℃; for 0.00138889h;98%
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

cyclopentanone
120-92-3

cyclopentanone

(2E,5E)-2,5-bis(4-methoxybenzylidene)cyclopentanone
5447-53-0, 106115-46-2

(2E,5E)-2,5-bis(4-methoxybenzylidene)cyclopentanone

Conditions
ConditionsYield
With lithium perchlorate; triethylamine at 20℃; for 0.0166667h;100%
With trichloro(trifluoromethanesulfonato)titanium(IV) at 20℃; for 2h; aldol condensation;97%
With animal bone meal catalyst modified with Na In water for 0.25h; Reflux;97%
cyclopentanone
120-92-3

cyclopentanone

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

ethyl 2-cyano-2-cyclopentylideneacetate
5407-83-0

ethyl 2-cyano-2-cyclopentylideneacetate

Conditions
ConditionsYield
piperidine at 23℃; under 750.06 Torr; for 2h; Knoevenagel condensation;100%
With morpholine; bis(acetylacetonate)oxovanadium at 40℃; for 1h; Reagent/catalyst; Temperature; Time; Knoevenagel Condensation;99%
With ammonium acetate; acetic acid In toluene Knoevenagel Condensation; Reflux;93%
cyclopentanone
120-92-3

cyclopentanone

2-chlorocyclopentanone
694-28-0

2-chlorocyclopentanone

Conditions
ConditionsYield
With iodine; mercury dichloride In dichloromethane for 1h; Ambient temperature;100%
With N-chloro-succinimide In various solvent(s) at 20℃; for 0.5h;91%
With N-chloro-succinimide In dimethyl sulfoxide at 20℃; for 0.25h;87%
cyclopentanone
120-92-3

cyclopentanone

Cyclopentanone oxime
1192-28-5

Cyclopentanone oxime

Conditions
ConditionsYield
With N,O-bis(trimethylsilyl)hydroxylamine; potassium hydride In tetrahydrofuran for 1.5h; Ambient temperature; - 78 deg C to room temp.;100%
With sodium hydroxide; hydroxylamine hydrochloride at 20℃; for 0.5h; grinding;100%
With hydroxylamine hydrochloride; sodium acetate In methanol Heating;100%
cyclopentanone
120-92-3

cyclopentanone

Cyclopentanol
96-41-3

Cyclopentanol

Conditions
ConditionsYield
With zirconium dioxide hydrate; isopropyl alcohol at 130℃; for 0.666667h; Meerwein-Ponndorf-Verley Reduction;100%
Stage #1: cyclopentanone With tetrabutylammonium tricarbonylnitrosylferrate; tricyclohexylphosphine In 1,4-dioxane at 50℃; Inert atmosphere;
Stage #2: With water; sodium hydroxide In 1,4-dioxane; methanol at 20℃; for 1.5h; Inert atmosphere; chemoselective reaction;
99%
With C15H18BF3; hydrogen; tert-butylimino-tri(pyrrolidino)phosphorane In tetrahydrofuran at 75℃; under 75007.5 Torr; for 20h; Glovebox;99%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

cyclopentanone
120-92-3

cyclopentanone

1-(trimethylsilyloxy)cyclopentene
19980-43-9

1-(trimethylsilyloxy)cyclopentene

Conditions
ConditionsYield
With triethylamine; sodium iodide In acetonitrile at 23℃; for 1.5h; Inert atmosphere;100%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 40℃; for 0.5h;98%
With magnesium In N,N-dimethyl-formamide at 15 - 25℃;94%
4-penten-1-ylmagnesium bromide
34164-50-6

4-penten-1-ylmagnesium bromide

cyclopentanone
120-92-3

cyclopentanone

1-(pent-4'-enyl)cyclopentan-1-ol
16133-77-0

1-(pent-4'-enyl)cyclopentan-1-ol

Conditions
ConditionsYield
100%
at 0℃;90%
In diethyl ether for 2h; Ambient temperature;72%
nitromethane
75-52-5

nitromethane

cyclopentanone
120-92-3

cyclopentanone

phenylmethanethiol
100-53-8

phenylmethanethiol

1-benzylthio-1-nitromethylcyclopentane
335458-23-6

1-benzylthio-1-nitromethylcyclopentane

Conditions
ConditionsYield
With piperidine In benzene100%
With piperidine In acetonitrile for 4h; Heating;94%
With piperidine In benzene Heating;
benzoic acid hydrazide
613-94-5

benzoic acid hydrazide

cyclopentanone
120-92-3

cyclopentanone

N'-cyclopentylidene benzohydrazide
24214-78-6

N'-cyclopentylidene benzohydrazide

Conditions
ConditionsYield
at 143℃; under 2100.21 Torr; for 0.05h; Microwave irradiation; neat (no solvent);100%
for 0.05h; Microwave irradiation;100%
at 20℃; for 0.05h; Microwave irradiation;100%
3,4-dimethoxy-benzaldehyde
120-14-9

3,4-dimethoxy-benzaldehyde

cyclopentanone
120-92-3

cyclopentanone

2,5-Bis<(3,4-dimethoxyphenyl)methylen>cyclopentanon
106115-49-5

2,5-Bis<(3,4-dimethoxyphenyl)methylen>cyclopentanon

Conditions
ConditionsYield
With lithium perchlorate; triethylamine at 20℃; for 96h;100%
With hydrogenchloride; acetic acid at 25 - 30℃; for 2h;85%
With hydrogenchloride In acetic acid at 25 - 30℃; for 2h;85%
allyl bromide
106-95-6

allyl bromide

cyclopentanone
120-92-3

cyclopentanone

1-allylcyclopentan-1-ol
36399-21-0

1-allylcyclopentan-1-ol

Conditions
ConditionsYield
With ammonium acetate; zinc In tetrahydrofuran at 0℃; for 0.166667h; Inert atmosphere;100%
With zinc; bis(cyclopentadienyl)titanium dichloride In tetrahydrofuran for 0.0833333h; Ambient temperature;98%
With ammonium chloride; zinc In tetrahydrofuran; water at 20℃; for 10h;90%
methanol
67-56-1

methanol

cyclopentanone
120-92-3

cyclopentanone

1,1-dimethoxycyclopentane
931-94-2

1,1-dimethoxycyclopentane

Conditions
ConditionsYield
With trimethyl orthoformate at 40℃; under 6000480 Torr; for 8h;100%
Irradiation;25%
Ce(3+)-mont at 25℃; for 0.5h; Yield given;
t-butoxycarbonylhydrazine
870-46-2

t-butoxycarbonylhydrazine

cyclopentanone
120-92-3

cyclopentanone

tert-butyl 2-cyclopentylidenehydrazine carboxylate
79201-39-1

tert-butyl 2-cyclopentylidenehydrazine carboxylate

Conditions
ConditionsYield
In methanol at 20℃; for 2h;100%
In methanol at 20℃; for 3h; Inert atmosphere;98%
In hexane for 0.333333h; Heating;96%
1-Bromonaphthalene
90-11-9

1-Bromonaphthalene

cyclopentanone
120-92-3

cyclopentanone

1-Naphthylcyclopentanol
74709-98-1

1-Naphthylcyclopentanol

Conditions
ConditionsYield
With iodine; magnesium In diethyl ether for 3h; Grignard reaction; Heating;100%
With iodine; magnesium 1.) ether, reflux, 2.) ether, benzene, RT, 2 h; Yield given. Multistep reaction;
Stage #1: 1-Bromonaphthalene With magnesium In diethyl ether
Stage #2: cyclopentanone In diethyl ether for 3h; Grignard reaction;
Stage #1: 1-Bromonaphthalene With magnesium In diethyl ether for 0.5h; Reflux;
Stage #2: cyclopentanone In diethyl ether at 0℃; for 1h;
2,4,6-trimethylbenzenesulfonohydrazide
16182-15-3

2,4,6-trimethylbenzenesulfonohydrazide

cyclopentanone
120-92-3

cyclopentanone

N'-cyclopentylidene-2,4,6-trimethylbenzenesulfonohydrazide
83477-71-8

N'-cyclopentylidene-2,4,6-trimethylbenzenesulfonohydrazide

Conditions
ConditionsYield
In methanol at 20℃;100%
In methanol 1.) 50 deg, 2.) room temperature;88%
t-butyldimethylsiyl triflate
69739-34-0

t-butyldimethylsiyl triflate

cyclopentanone
120-92-3

cyclopentanone

1-tert-butyldimethylsilyloxycyclopentene
68081-15-2

1-tert-butyldimethylsilyloxycyclopentene

Conditions
ConditionsYield
With triethylamine In dichloromethane for 0.0833333h;100%
With 2,6-dimethylpyridine In tetrahydrofuran at 0℃; for 1h;71%
With triethylamine In dichloromethane at 0℃;
ethyl hydrogen (5,6-dihydro-p-dioxin-2-yl)ethylphosphonite
78396-88-0

ethyl hydrogen (5,6-dihydro-p-dioxin-2-yl)ethylphosphonite

cyclopentanone
120-92-3

cyclopentanone

ethyl (5,6-dihydro-p-dioxin-2-yl)(1-hydroxycyclopentyl)phosphinate

ethyl (5,6-dihydro-p-dioxin-2-yl)(1-hydroxycyclopentyl)phosphinate

Conditions
ConditionsYield
for 600h; Ambient temperature;100%
cyclopentanone
120-92-3

cyclopentanone

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2,3-cyclopentano-3,4-dihydro-5H-4-spirocyclopentano-1,5-benzodiazepine
41526-78-7

2,3-cyclopentano-3,4-dihydro-5H-4-spirocyclopentano-1,5-benzodiazepine

Conditions
ConditionsYield
With mesoporous aluminosilicate MCM-41(14) at 100℃; for 1h;100%
With ytterbium(III) triflate at 20℃; for 4h;99%
With octadecafluorodecahydronaphthalene (cis+trans) at 60℃; for 2h;99%
cyclopentanone
120-92-3

cyclopentanone

toluene-4-sulfonic acid hydrazide
1576-35-8

toluene-4-sulfonic acid hydrazide

cyclopentanone p-tolylsulfonylhydrazone
17529-98-5

cyclopentanone p-tolylsulfonylhydrazone

Conditions
ConditionsYield
In ethanol at 100℃; for 1h;100%
In ethanol at 100℃; for 1.66667h; Inert atmosphere;100%
In methanol at 20℃; Inert atmosphere;99.5%
cyclopentanone
120-92-3

cyclopentanone

2-amino-1-benzylamine
4403-69-4

2-amino-1-benzylamine

3',4'-dihydro-1'H-spiro[cyclopentane-1,2'-quinazoline]
84571-63-1

3',4'-dihydro-1'H-spiro[cyclopentane-1,2'-quinazoline]

Conditions
ConditionsYield
In chloroform at 60℃; for 24h;100%
With acetic acid In ethanol for 3h; Heating;82%
cyclopentanone
120-92-3

cyclopentanone

4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

1-cyclopent-1-enyl 4-fluorobenzene
827-57-6

1-cyclopent-1-enyl 4-fluorobenzene

Conditions
ConditionsYield
Stage #1: cyclopentanone; 4-flourophenylmagnesium bromide In tetrahydrofuran at 0℃; Reflux;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
100%
In tetrahydrofuran; diethyl ether at 0℃; for 2h; Reflux;100%
Stage #1: cyclopentanone; 4-flourophenylmagnesium bromide In tetrahydrofuran at 0℃; for 2h; Reflux;
Stage #2: With hydrogenchloride; water In tetrahydrofuran Cooling with ice;
100%
In diethyl ether Grignard reaction; Reflux;61%
(i), (ii) KHSO4; Multistep reaction;
furfural
98-01-1

furfural

cyclopentanone
120-92-3

cyclopentanone

α,α'-bis(2-furylmethylidene)cyclopentanone

α,α'-bis(2-furylmethylidene)cyclopentanone

Conditions
ConditionsYield
With sodium hydroxide In ethanol for 0.0166667h; microwave irradiation;100%
With aluminum oxide; potassium fluoride In methanol at 35 - 40℃; for 0.5h; Claisen-Schmidt condensation; ultrasound irradiation;96%
With sodium-modified hydroxyapatite In water for 0.5h; Aldol condensation; Reflux;96%
nitromethane
75-52-5

nitromethane

thiophenol
108-98-5

thiophenol

cyclopentanone
120-92-3

cyclopentanone

1-nitromethyl-1-phenylthiocyclopentane
109585-27-5

1-nitromethyl-1-phenylthiocyclopentane

Conditions
ConditionsYield
With piperidine In benzene for 61h; Heating;100%

120-92-3Related news

Improving stability of Cyclopentanone (cas 120-92-3) aldol condensation MgO-based catalysts by surface hydrophobization with organosilanes09/06/2019

Cyclopentanone is a promising building block in the conversion of biomass to fuels. It can be readily obtained from furanics derived from biomass and can be converted to intermediate products in the molecular weight range compatible with fuels via CC bond forming reactions. Among them, aldol con...detailed

Highly efficient hydrogenative ring-rearrangement of furanic aldehydes to Cyclopentanone (cas 120-92-3) compounds catalyzed by noble metals/MIL-MOFs09/05/2019

Hydrogenative ring-rearrangement reaction of biomass-derived furanic aldehydes to cyclopentanone compounds catalyzed by metal/support bifunctional catalysts suffers a low selectivity of target product and serious carbon loss because of the Brønsted acid catalysis. Herein, a series of pure Lewis ...detailed

Laminar flame characteristics of Cyclopentanone (cas 120-92-3) at elevated temperatures09/02/2019

Cyclopentanone, a product of biomass pyrolysis of agricultural waste, has certain advantages as a biofuel candidate but so far little is known about its combustion characteristics. In this paper, the laminar flame characteristics of cyclopentanone, including stretched flame propagation speed, un...detailed

Short communicationPd/Cu-MOF as a highly efficient catalyst for synthesis of Cyclopentanone (cas 120-92-3) compounds from biomass-derived furanic aldehydes08/31/2019

Herein, a series of Pd nanoparticles supported on Cu-MOFs (Cu3(BTC)2, FeCu-DMC) with pure Lewis acidity are synthesized for hydrogenative ring-rearrangement reaction of furanic aldehydes (furfural, 5-hydroxymethyl furfural) to cyclopentanone compounds (cyclopentanone, 3-hydroxymethyl cyclopentan...detailed

Role of water in Cyclopentanone (cas 120-92-3) self-condensation reaction catalyzed by MCM-41 functionalized with sulfonic acid groups08/30/2019

Water is ubiquitous in many catalytic reactions used in the upgrading of biomass. Therefore, quantifying and controlling the influence of water in activity, selectivity, and catalyst deactivation is essential for advancing this technology. Here, we report a kinetic study of the cyclopentanone se...detailed

120-92-3Relevant articles and documents

Efficient conversion of furfural into cyclopentanone over high performing and stable Cu/ZrO2 catalysts

Zhang, Yifeng,Fan, Guoli,Yang, Lan,Li, Feng

, p. 117 - 126 (2018)

Currently, biomass transformation to produce high value-added chemicals and liquid biofuels is attracting more and more interest by the virtue of its importance in the sustainable development of human society. Herein, we reported the conversion of furfural (FFA) into cyclopentanone (CPO) in water over high performing and stable Cu/ZrO2 catalysts prepared by our developed one-pot reduction-oxidation method. It was demonstrated that surface structures and catalytic performances of catalysts could be delicately adjusted by varying the calcination temperatures for catalyst precursors. Especially, an appropriate calcination temperature of 500 °C could significantly enhance the interactions between surface Cu species and the ZrO2 support, thus greatly facilitating the formation of Cu+-O-Zr-like structure at the metal-support interface, and the resulting Cu/ZrO2 catalyst showed a superior catalytic performance with a high CPO yield of 91.3% under mild reaction conditions (i.e. a low hydrogen pressure of 1.5 MPa and 150 °C) to other metal oxides supported copper catalysts prepared by the conventional impregnation. It was revealed that in addition to surface acidic sites, surface Cu+/(Cu°+Cu+) ratio also played a key role in promoting the formation of CPO in the present Cu/ZrO2 catalytic system.

Catalytic Oxidation of Cyclopentene by O2 over Pd(II)-SBA-15 Complexes

Yue, Lumin,Wang, Zhenwei,Bao, Lele,Fu, Wei,Xu, Li,Li, Jun,Lu, Guanzhong

, p. 2269 - 2278 (2017)

Abstract: Novel catalysts with Pd(II)-picolinamide complexes anchored into the channels of mesoporous material SBA-15 were prepared for chemical transformation of cyclopentene, and characterized in details. Spectra of 29Si NMR, 13C NMR and XPS revealed the organic ligands were grafted into the SBA-15 and Pd(II) complexes formed. Spacial diversity of the complexes, especially distances from –C=O to N on pyridyl cycles, may influence electronic distribution of conjugated system and further the catalytic activity. With the help of the newly synthesized catalytic materials, a new heterogeneous oxidation system was developed for selective catalytic transformation of cyclopentene to cyclopentanone with molecular oxygen as the sole oxidant. Analytic results of the reaction mixtures indicated that all catalysts exhibited high activity, while the cat.1 and cat.2 with 2-pyridinecarbonyl or 3-pyridinecarbonyl on the ligands gave better yields of cyclopentanone. 96.2% conversion of cyclopentene and 76.3% yied of cyclopentanone were achieved over the catalyst cat.2 under the conditions of 0.7?MPa O2, 323?K and 6?h reaction. In addition, the catalysts were also appealing for easy separation and recyclable property. Graphical Abstract: [Figure not available: see fulltext.] A new heterogeneous reaction system was developed for the catalytic oxidation of cyclopentene to cyclopentanone by molecular oxygen over novel catalysts. The synthesized catalysts are comprised of Pd(II)-picolinamide complexes anchored into the channels of SBA-15. The new system was efficient for the mentioned reaction, and the catalysts were reusable.

PREPARATION OF KETONES BY A NOVEL DECARBALKOXYLATION OF β-KETO ESTERS: STEREOELECTRONIC ASSISTANCE TO C-C BOND FISSION

Aneja, R.,Hollis, W. M.,Davies A. P.,Eaton, G.

, p. 4641 - 4644 (1983)

Reaction of β-keto esters with the sodium derivative of propane-1,2-diol in an excess of anhydrous propane-1,2-diol causes facile decarboxylation to ketones in excellent yields.

Trinuclear triangular copper(II) clusters - Synthesis, electrochemical studies and catalytic peroxidative oxidation of cycloalkanes

Di Nicola, Corrado,Garau, Federica,Karabach, Yauhen Y.,Martins, Luisa M. D. R. S.,Monari, Magda,Pandolfo, Luciano,Pettinari, Claudio,Pombeiro, Armando J. L.

, p. 666 - 676 (2009)

The reactions of CuII carboxylates (valerate, 2-methylbutyrate, hexanoate, heptanoate) with pyrazole (Hpz) in EtOH or EtOH/water solutions easily afford the triangular trinuclear copper derivatives [Cu 3(μ3-OH)(μ-pz)3(RCOO)2(L) x] [R = CH3(CH2)3, L = H 2O, x = 1 for 5; R = CH3CH2CH(CH3), L = EtOH, x = 2 for 6; R = CH3(CH2)4, L = EtOH, x = 1 for 7; R = CH3(CH2)5, L = EtOH, x = 1 for 8] as it has been previously found for R = H, L = Hpz, x = 2, (1); R = CH3, L = Hpz, x = 1, (2); R = CH3CH2, L = EtOH, x = 1, (3) and [Cu3(μ3-OH)(μ-pz) 3-(CH3(CH2)2COO)2(MeOH) (H2O)], (4). The trinuclear structure common to 5-8 has been assigned on the basis of magnetic susceptibility studies, ESI MS, IR and UV/Vis spectroscopy as well as 1H NMR measurements. The room temp. magnetic susceptibilities of 5-8 almost correspond to the presence of a single unpaired electron for each trinuclear unit. The IR spectra exhibit signals due to the bridging μ3-OH in accordance with what was observed in the spectra of 1-4. Solid-state and MeOH solution UV/Vis spectra show the same features previously reported for 1-4 and 1H NMR spectra of 1-8 show almost identical low field signals that can be assigned to pz- hydrogens. A detailed investigation of the supramolecular structures of 1 and 4 and the single-crystal X-ray study of the polymeric paddlewheel Cu(2-methylbutyrate) 2, A, are also reported. Electrochemical experiments show that in 1-8 the CuII ions can be reduced, in distinct steps, to CuI and Cu0. All the complexes act as catalysts or catalyst precursors for the efficient peroxidative oxidation, by aqueous hydrogen peroxide in acetonitrile and at room temp., of cycloalkanes RH (cyclohexane and cyclopentane) to the corresponding cyclic alcohols and ketones, with overall yields of up to 34% and TONs up to 42. Radical pathways involving the formation of alkyl hydroperoxides (ROOH) are involved. Wiley-VCH Verlag GmbH & Co. KGaA, 2009.

Synthesis of Unsaturated Spiroacetals, Cyclopentanone Derivatives, in the Presence of Natural Aluminosilicate Modified with Zirconium Cations

Abbasov,Alimardanov, Kh. M.,Abbaszade,Guseinova,Azimli

, p. 603 - 607 (2019)

Abstract: Conditions for the condensation of cyclopentanone and n-valeric aldehyde to 2-pentylidenecyclopentanone in the presence of an alcoholic solution of piperidine have been developed. The isomerization of the latter in a continuous-flow system over γ-Al2O3 yields 2-pentylcyclopent-2-en-1-one. The condensation of the obtained unsaturated ketones with ethane-1,2-diol in the presence of a heterogeneous catalyst, a natural aluminosilicate (perlite) modified with zirconyl sulfate, has been studied. The optimum conditions for the preparation of the corresponding unsaturated spiroacetals have been found. The synthesized compounds can be used as synthetic fragrances for different purposes.

Kinetics and mechanisms of the thermal decomposition of 2-methyl-1,3-dioxolane, 2,2-dimethyl-1,3-dioxolane, and cyclopentanone ethylene ketal in the gas phase. Combined experimental and DFT study

Rosas, Felix,Lezama, Jesus,Mora, Jose R.,Maldonado, Alexis,Chuchani, Gabriel,Cordova, Tania

, p. 9228 - 9237,10 (2012)

The kinetics of the gas-phase thermal decomposition of 2-methyl-1,3- dioxolane, 2,2-dimethyl-1,3-dioxolane, and cyclopentanone ethylene ketal were determined in a static system and the reaction vessel deactivated with allyl bromide. The decomposition reactions, in the presence of the free radical suppressor propene, are homogeneous, are unimolecular, and follow first-order law kinetics. The products of these reactions are acetaldehyde and the corresponding ketone. The working temperature range was 459-490 °C, and the pressure range was 46-113 Torr. The rate coefficients are given by the following Arrhenius equations: for 2-methyl-1,3-dioxolane, log k = (13.61 ± 0.12) - (242.1 ± 1.0)(2.303RT)-1, r = 0.9997; for 2,2-dimethyl-1,3-dioxolane, log k = (14.16 ± 0.14) - (253.7 ± 2.0)(2.303RT)-1, r = 0.9998; for cyclopentanone ethylene ketal, log k = (14.16 ± 0.14) - (253.7 ± 2.0)(2.303RT)-1, r = 0.9998. Electronic structure calculations using DFT methods B3LYP and MPW1PW91 with 6-31G(d,p), and 6-31++G(d,p) basis sets suggest that the decomposition of these substrates takes place through a stepwise mechanism. The rate-determining step proceeds through a concerted nonsynchronous four-centered cyclic transition state, and the elongation of the C-OCH3 bond in the direction C αδ+...OCH3δ- is predominant. The intermediate products of these decompositions are unstable, at the working temperatures, decomposing rapidly through a concerted cyclic six-centered cyclic transition state type of mechanism.

Regeneration of aldehydes and ketones from oximes using bis(trimethylsilyl)chromate

Lee,Kwak,Hwang

, p. 2425 - 2429 (1992)

Bis(trimethylsilyl) chromate transforms oximes of not only ketones but also aldehydes and 1,2-diketones to the corresponding carbonyl compounds, in high yields.

Catalytic oxidation of cycloalkanes by porphyrin cobalt(II) through efficient utilization of oxidation intermediates

Shen, Hai M.,Wang, Xiong,Guo, A. Bing,Zhang, Long,She, Yuan B.

, p. 1166 - 1173 (2020)

The catalytic oxidation of cycloalkanes using molecular oxygen employing porphyrin cobalt(II) as catalyst was enhanced through use of cycloalkyl hydroperoxides, which are the primary intermediates in oxidation of cycloalkanes, as additional oxidants to further oxidize cycloalkanes in the presence of porphyrin copper(II), especially for cyclohexane, for which the selectivity was enhanced from 88.6 to 97.2% to the KA oil; at the same time, the conversion of cyclohexane was enhanced from 3.88 to 4.41%. The enhanced efficiency and selectivity were mainly attributed to the avoided autoxidation of cycloalkanes and efficient utilization of oxidation intermediate cycloalkyl hydroperoxides as additional oxidants instead of conventional thermal decomposition. In addition to cyclohexane, the protocol presented in this research is also very applicable in the oxidation of other cycloalkanes such as cyclooctane, cycloheptane and cyclopentane, and can serve as a applicable and efficient strategy to boost the conversion and selectivity simultaneously in oxidation of alkanes. This work also is a very important reference for the extensive application of metalloporphyrins in catalysis chemistry.

Mild homogeneous oxidation and hydrocarboxylation of cycloalkanes catalyzed by novel dicopper(II) aminoalcohol-driven cores

Fernandes, Tiago A.,André, Vania,Kirillov, Alexander M.,Kirillova, Marina V.

, p. 357 - 367 (2017)

N-benzylethanolamine (Hbea) and triisopropanolamine (H3tipa) were applied as unexplored aminoalcohol N,O-building blocks for the self-assembly generation of two novel dicopper(II) compounds, [Cu2(μ-bea)2(Hbea)2](NO3)2 (1) and [Cu2(H3tipa)2(μ-pma)]·7H2O (2) {H4pma = pyromellitic acid}. These were isolated as stable and aqua-soluble microcrystalline products and were fully characterized by IR spectroscopy, ESI–MS(±), and single-crystal X-ray diffraction, the latter revealing distinct Cu2 cores containing the five-coordinate copper(II) centers with the {CuN2O3} or {CuNO4} environments. Compounds 1 and 2 were used as homogeneous catalysts for the mild oxidation of C5–C8 cycloalkanes to give the corresponding cyclic alcohols and ketones in up to 23% overall yields based on cycloalkane. The reactions proceed in aqueous acetonitrile medium at 50 °C using H2O2 as an oxidant. The effects of different reaction conditions were studied, including the type and loading of catalyst, amount and kind of acid promoter, and water concentration. Despite the fact that different acids (HNO3, H2SO4, HCl, or CF3COOH) promote the oxidation of alkanes, the reaction is exceptionally fast in the presence of a catalytic amount of HCl, resulting in the TOF values of up to 430 h?1. Although water typically strongly inhibits alkane oxidations due to the reduction of H2O2 concentration and lowering of the alkane solubility, in the systems comprising 1 and 2 we observed a significant growth (up to 5-fold) of an initial reaction rate in the cyclohexane oxidation on increasing the amount of H2O in the reaction mixture. The bond-, regio- and stereo-selectivity parameters were investigated in oxidation of different linear, branched, and cyclic alkane substrates. Both compounds 1 and 2 also catalyze the hydrocarboxylation of C5–C8 cycloalkanes, by CO, K2S2O8, and H2O in a water/acetonitrile medium at 60 °C, to give the corresponding cycloalkanecarboxylic acids in up to 38% yields based on cycloalkanes.

Highly dispersed Co and Ni nanoparticles encapsulated in N-doped carbon nanotubes as efficient catalysts for the reduction of unsaturated oxygen compounds in aqueous phase

Gong, Wanbing,Chen, Chun,Zhang, Haimin,Wang, Guozhong,Zhao, Huijun

, p. 5506 - 5514 (2018)

N-Doped carbon nanotube-encapsulated metal nanoparticles are of great interest in heterogeneous catalysis owing to their improved mass transfer ability and superior stability. Herein, a facile one-pot pyrolysis approach using melamine as the carbon and nitrogen source was developed to fabricate metal nanoparticles embedded in bamboo-like N-doped carbon nanotubes (named as Co@NCNTs-600-800 and Ni@NCNTs-600-800). The optimized Co@NCNTs-600-800 catalyst exhibited outstanding activity in furfural (FAL) selective hydrogenation to furfuryl alcohol (FOL) or cyclopentanone (CPO) in aqueous media. High yields of FOL (100%) and CPO (75.3%) were achieved at 80 °C and 140 °C, respectively. Besides, this cobalt catalyst showed very good stability and recyclability during the reaction. The synergistic effect between metallic cobalt and N-doped carbon nanotubes was systematically investigated. In addition, the as-prepared Ni@NCNTs-600-800 catalyst also exhibited remarkable activity. Under optimal conditions (100 °C and 4 MPa H2 pressure), a maximum tetrahydrofurfuryl alcohol (THFOL) yield (99.5%) was obtained in the aqueous-phase hydrogenation of FAL. The research thus highlights new perspectives for non-noble metal-based N-doped carbon nanotube catalysts for biomass transformation.

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