- Enantioselective Synthesis of Isoflavanones by Catalytic Dynamic Kinetic Resolution
-
A ruthenium-catalyzed asymmetric transfer hydrogenation of racemic isoflavanones with dynamic kinetic resolution yields virtually enantiopure isoflavanols as single diastereomers. Subsequent oxidation gives rise to isoflavanones in high enantiomeric purit
- Qin, Tao,Metz, Peter
-
p. 2981 - 2984
(2017/06/07)
-
- Benzoxazepine derivatives as selective estrogen receptor modulators
-
The present invention is directed to novel benzoxazepine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and diseases mediated by an estrogen receptor.
- -
-
Page/Page column 6
(2008/06/13)
-
- A simple one-pot synthesis of isoflavanones
-
A new simple one-pot synthesis of isoflavanones 2 by reaction of benzyl 2-hydroxyphenylketones 1 with bis(dimethylamino)methane in boiling ethanol is described.
- Valenti, Piero,Belluti, Federica,Rampa, Angela,Bisi, Alessandra
-
p. 3895 - 3899
(2007/10/03)
-
- Organolead-mediated Arylation of Allyl β-Ketoesters: A Selective Synthesis of Isoflavanones and Isoflavones
-
Arylation of A-ring substituted and unsabstituted 3-allyloxycarbonylchroman-4-ones with aryllead(IV) triacetates followed by selective catalytic deallyloxycarbonylation affords isoflavanones or isoflavones in high overall yields.The highest yield in the arylation step was observed in the reaction of 5,7-dimethoxychroman-4-one with the more hindered 2,4,6-trimethoxyphenyllead triacetate.
- Donnelly, Dervilla M.,Finet, Jean-Pierre,Rattigan, Bernard A.
-
p. 1729 - 1736
(2007/10/02)
-
- A New General Synthesis of Hydroxy- and Methoxy-isoflavones
-
A new general synthesis of hydroxy- (5e-h) and methoxy- (5e-d) isoflavones has been accomplished in overall yields of 47-73percent from the corresponding 2-hydroxydeoxybenzoins (1a-h).The first step involves reaction with appropriate amounts of ethoxymeth
- Jain, Amolak C.,Mehta, Anita
-
p. 215 - 220
(2007/10/02)
-
- Hydroxymethylation Studies of o-Hydroxyphenyl Benzyl Ketones with and without the use of Phase Transfer Catalyst: A Novel Synthesis of Isoflavanones
-
o-Hydroxyphenyl benzyl ketones, having a resorcinol unit in ring-A, on treatment with formalin in chloroform-aq. potassium carbonate biphase system give the corresponding α-hydroxymethyl derivatives.This reaction when carried out in the presence of a phas
- Jain, P. K.,Makrandi, J. K.,Grover, S. K.
-
-
- A Convenient Phase Transfer Catalysed Synthesis of Isoflavanones
-
o-Hydroxyphenyl benzyl ketones (1, 4, 6, 8, 10, 12) on treatment with diiodomethane under phase transfer catalysed conditions in the presence of n-tetrabutylammonium iodide and sodium thiosulphate have been found to undergo smooth conversion into the corresponding isoflavanones (2, 5, 7, 9, 11, 13) in good yields (60-70percent).
- Singh, Harcharan,Jain, P. K.,Makrandi, J. K.,Grover, S. K.
-
p. 547 - 548
(2007/10/02)
-