152857-38-0Relevant articles and documents
Nickel-Catalyzed Intramolecular C?O Bond Formation: Synthesis of Cyclic Enol Ethers
Han, Seo-Jung,Doi, Ryohei,Stoltz, Brian M.
, p. 7437 - 7440 (2016)
An efficient and exceptionally mild intramolecular nickel-catalyzed carbon–oxygen bond-forming reaction between vinyl halides and primary, secondary, and tertiary alcohols has been achieved. Zinc powder was found to be an essential additive for obtaining
Asymmetric amination of meso-epoxide with vegetable powder as a low-toxicity catalyst
Asano, Tatsuhiro,Kurata, Hiroyuki,Takeuchi, Yuki,Tsuzaki, Kazuya,Wada, Koichi
, (2020/08/11)
This paper describes the scope and limitation of substrates subjected to asymmetric amination with epoxides catalyzed by a soluble soybean polysaccharide (Soyafibe S-DN), which we recently discovered from the reaction of 1,2-epoxycyclohexane with cyclopropylamine. Various meso-epoxides reacted with various amines afforded the corresponding products with good enantiomeric selectivity. Since it was found that pectin was found to have a catalytic ability after screening commercially available polysaccharides, we studied 33 different vegetable powders having pectic substances, and we found that many vegetable powders showed catalytic ability. These results should guide in using vegetable components as low-toxic catalysts for the production of pharmaceuticals.
Solvent-Directed Epoxide Opening with Primary Amines for the Synthesis of β-Amino Alcohols
Lizza, Joseph R.,Moura-Letts, Gustavo
supporting information, p. 1231 - 1242 (2017/03/11)
An efficient synthesis of β-amino alcohols from a variety of epoxides and primary unbranched amines in the absence of any catalyst in high yields and regioselectivities is reported. A variety of polar mixed solvent systems allow for the selective formation of secondary amino alcohols over tertiary amino alcohols. The reaction scope extends to a wide variety of aromatic and aliphatic substituted epoxides and primary amines bearing complex functionality.
Synthesis of nitrile coordinated Lewis acids Al(OC(CF3) 2R)3 and their application in catalytic epoxide ring-opening reactions
Li, Yang,Tan, Yi,Herdtweck, Eberhardt,Cokoja, Mirza,Kühn, Fritz E.
experimental part, p. 171 - 176 (2010/11/04)
Four nitrile ligated aluminum-based Lewis acids PhCNAl(OC(CF 3)2PhCH3)3 (1), CH 3CNAl(OC(CF3)2PhCH3)3 (2), PhCNAl(OC(CF3)2Ph)3 (3), CH 3CNAl(OC(CF3)2Ph)3 (4) were synthesized and characterized by nuclear magnetic resonance and infrared spectroscopy, as well as X-ray crystallography. The ring-opening reactions of epoxides with aromatic/aliphatic amines were efficiently catalyzed by compounds 1-4 as catalysts in a concentration of 1 mol% under solvent-free conditions at room temperature, affording 2-amino alcohols in high yields (up to 99%) within 4 h. Compound 1, being the best catalyst, yields 70% product within 10 min. Published by Elsevier B.V.
Process for preparing 1,2-diamino compounds
-
, (2008/06/13)
The invention provides a multistep process for preparing 1,2-diamino compounds and pharmaceutically acceptable addition salts thereof from 1,2-epoxides.
SYNTHESE DES MORPHOLINES. II. ALLYLATION CHIMIOSELECTIVE DES 2-AMINOALCOOLS, PRODUITS DE DEPART POUR LA FORMATION DES MORPHOLINES.
Dobrev, Alexandre,Spasov, Stefan,Lattes, Armand
, p. 1601 - 1619 (2007/10/02)
La reaction d'allylation des 2-aminoalcools est une reaction chimioselective donnant un acces facile et avec des bons rendements aux alcools correspondants exclusivement N-allyles.Leurs structures ont ete prouvees par spectrometrie de masse, IR et 1H RMN.
