15324-42-2Relevant articles and documents
Synthesis, biological evaluation, and docking studies of tetrahydrofuran-cyclopentanone-and cyclopentanol-based ligands acting at adrenergic α1- and serotonine 5-HT1A receptors
Prandi, Adolfo,Franchini, Silvia,Manasieva, Leda Ivanova,Fossa, Paola,Cichero, Elena,Marucci, Gabriella,Buccioni, Michela,Cilia, Antonio,Pirona, Lorenza,Brasili, Livio
experimental part, p. 23 - 36 (2012/03/11)
A series of aralkylphenoxyethylamine and aralkylmethoxyphenylpiperazine compounds was synthesized and their in vitro pharmacological profile at both 5-HT1A receptors and α1-adrenoceptor subtypes was measured by binding assay and func
Catalytic and regioselective ring expansion of arylcyclobutanones with trimethylsilyldiazomethane. Ligand-dependent entry to β-ketosilane or enolsilane adducts
Dabrowski, Jennifer A.,Moebius, David C.,Wommack, Andrew J.,Kornahrens, Anne F.,Kingsbury, Jason S.
supporting information; experimental part, p. 3598 - 3601 (2010/11/04)
Divergent reactivity is uncovered in the homologation of arylcyclobutanones with trimethylsilyldiazomethane. With Sc(OTf)3 as catalyst, enolsilanes are obtained with a high preference for methylene migration. By contrast, Sc(hfac)3 g
Reactions of methylenecyclobutanes with silver acetate and iodine
Jiang, Min,Liu, Le-Ping,Shi, Min
, p. 9599 - 9604 (2008/02/11)
Methylenecyclobutanes undergo an interesting rearrangement reaction in the presence of silver acetate and iodine at room temperature (20 °C) in dichloromethane to give the corresponding aryl-(1-arylcyclobutyl)methanones in good to high yields within short
Preparation of Alkylidenecyclobutanes and Their Transformation to 2,2-Disubstituted Cyclopentanones
Fujiwara, Tooru,Iwasaki, Norie,Takeda, Takeshi
, p. 741 - 742 (2007/10/03)
The reaction of ketones with the titanocene reagent prepared by the treatment of 1,1-bis(phenylthio)cyclobutane with the low valent titanium species Cp2Ti2 produced the corresponding alkylidenecyclobutanes. These compounds were successfully trans
Direct α-arylation of ketones: The reaction of cyclic ketone enolates with diphenyliodonium triflate
Ryan, John H.,Stang, Peter J.
, p. 5061 - 5064 (2007/10/03)
Diphenyliodonium triflate 1a reacts with the lithium enolates of cyclic ketones 2 (ring size = 5 - 8), in the presence of stoichiometric quantities of copper cyanide, to afford the corresponding α-phenylated ketones 3 or α,α'-diphenylated ketones 4.
Nitroalkene Inter /Intra Tandem Cycloadditions. 7. Application of (R)-(-)-2,2-Diphenylcyclopentanol as the Chiral Auxiliary
Denmark, Scott E.,Schnute, Mark E.,Marcin, Lawrence R.,Thorarensen, Atli
, p. 3205 - 3220 (2007/10/02)
Chiral enol ethers derived from (R)-(-)-2,2-diphenylcyclopentanol ((-)3) have been found to provide high levels of asymmetric induction in tandem inter /intra nitroalkene cycloadditions.The chiral auxiliary (>97percent ee) is readily prepar
Direct and Regiocontrolled Synthesis of α-Phenyl Ketones from Silyl Enol Ethers and Diphenyliodonium Fluoride
Chen, Kuanchiang,Koser, Gerald F.
, p. 5764 - 5767 (2007/10/02)
The efficiacy of diphenyliodonium fluoride (1, DIF) for the phenylation of silyl enol ethers was investigated.When the silyl enol ethers of cyclopentanone, 2-methylcyclopentanone, cyclohexanone, 2-methylcyclohexanone, acetophenone, 2-pentanone, diisopropyl ketone, and pinacolone were mixed with DIF in tetrahydrofuran, either α-phenyl or α,α-diphenyl ketones were produced and isolated in yields ranging from 20 to 88percent.That the regiochemistry of α-phenylation can be controlled by an appropriate choice of silyl enol ether was demonstrated with the kinetic and thermodynamic silyl enol ethers of 2-methylcyclohexanone, the thermodynamic silyl enol ether of 2-methylcyclopentanone, and the kinetic silyl enol ether of 2-pentanone. 3,3-Dimethyl-2-(silyloxy)-1-butene gave a dehydro dimer of pinacolone with DIF in addition to α-phenylpinacolone, thus suggesting that phenylations of silyl enol ethers with DIF may proceed via radical intermediates.
