The physicochemical properties of some nitrogen-containing peroxides
The enthalpies of formation of four nitrogen-containing peroxides in the liquid and gaseous states were determined. The enthalpy contributions of the C-(H)2(O)(N) increment to the Benson, Lebedev-Miroshnichenko, and Kinzin-Dvorkin additive schemes and the O-O and C-N bond energies were calculated.
Twelve t-butylperoxyamines (6-17) were synthesized as targeted antimalarials and evaluated for antimalarial activity in vivo against Plasmodium berghei in mice and in vitro against both chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum. Compound 8 was found to have highest potency with activity at 80 and 160 mg/kg dose in vivo and compound 11 exhibited highest efficacy in vitro.