Welcome to LookChem.com Sign In|Join Free

CAS

  • or
2-Isopropyl-5-phenyltetrazole is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

153478-97-8 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 153478-97-8 Structure
  • Basic information

    1. Product Name: 2-Isopropyl-5-phenyltetrazole
    2. Synonyms: 2-Isopropyl-5-phenyltetrazole
    3. CAS NO:153478-97-8
    4. Molecular Formula: C10H12N4
    5. Molecular Weight: 188.23
    6. EINECS: N/A
    7. Product Categories: API intermediates
    8. Mol File: 153478-97-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Isopropyl-5-phenyltetrazole(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Isopropyl-5-phenyltetrazole(153478-97-8)
    11. EPA Substance Registry System: 2-Isopropyl-5-phenyltetrazole(153478-97-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 153478-97-8(Hazardous Substances Data)

153478-97-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 153478-97-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,4,7 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 153478-97:
(8*1)+(7*5)+(6*3)+(5*4)+(4*7)+(3*8)+(2*9)+(1*7)=158
158 % 10 = 8
So 153478-97-8 is a valid CAS Registry Number.

153478-97-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-phenyl-2-propan-2-yltetrazole

1.2 Other means of identification

Product number -
Other names 2-ISOPROPYL-5-PHENYLTETRAZOLE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:153478-97-8 SDS

153478-97-8Downstream Products

153478-97-8Relevant articles and documents

Reactions of Azolium Cations. II. Regioselective N2 Alkylation of 5-Aryltetrazoles with Isopropyl Alcohol in Sulfuric Acid Media: Effect of Electronic Properties of Aryl Substituents on the Reaction Rate

Koren, A. O.,Gaponik, P. N.,Ostrovskii, V. A.

, p. 919 - 924 (1995)

Kinetics of regioselective N2 alkylation of a series of 5-(R-phenyl)tetrazoles with isopropyl alcohol has been studied in 88.2, 94.3, and 98.3percent (w/w) sulfuric acid at 25 deg.The true rate constants were evaluated, logarithms of which were found to correlate with ?0 constants of phenyl substituents as log k = -0.488?0 - 0.417.Small value of Hammett constant ρ is evidence of a considerable isolation of the reaction center from the influence of the substituent at position C5 of the heteroring.This conclusion is confirmed by results of MNDO quantum chemical calculations of a series of 5-substituted tetrazolium cations.A correlation between logarithms of the true rate constants and the calculated net effective charges on atoms N2(N3) for 5-(R-phenyl)tetrazolium cations has been revealed.

Alkylation of 5-Substituted 1 H-Tetrazoles via the Diazotization of Aliphatic Amines

Lebel, Hélène,Reynard, Guillaume

, p. 12452 - 12459 (2021/09/07)

A new alkylation reaction of monosubstituted tetrazoles via the diazotization of aliphatic amines is reported. This method enables preferential formation of 2,5-disubstituted tetrazoles. A one-pot 1,3-dipolar cycloaddition/diazotization sequence starting from widely available nitriles is also described. Azide residues are quenched in the second step with the nitrite reagent, thus limiting the intrinsic risk associated with trimethylsilyl azide. The reaction conditions were compatible with several functional groups, including thiocyanates, which afford preferentially disubstituted 2-alkyl-5-(substituted-thio)tetrazoles.

Regio- and Enantioselective Synthesis of Azole Hemiaminal Esters by Lewis Base Catalyzed Dynamic Kinetic Resolution

Piotrowski, David W.,Kamlet, Adam S.,Dechert-Schmitt, Anne-Marie R.,Yan, Jiangli,Brandt, Thomas A.,Xiao, Jun,Wei, Liuqing,Barrila, Mark T.

supporting information, p. 4818 - 4823 (2016/05/09)

We report a modular three-component dynamic kinetic resolution (DKR) that affords enantiomerically enriched hemiaminal esters derived from azoles and aldehydes. The novel and scalable reaction can be used to synthesize valuable substituted azoles in a regioselective manner by capping (e.g., acylation) of the equilibrating azole-aldehyde adduct. With the use of a prolinol-derived DMAP catalyst as the chiral Lewis base, the products can be obtained in high chemical yield and with high enantiomeric excess. The DKR was performed on a multikilogram scale to produce a tetrazole prodrug fragment for a leading clinical candidate that posed formidable synthesis challenges.

Alkylation of 5-substituted NH-tetrazoles by alcohols in the superacid CF3SO3H

Lisakova, Anna D.,Ryabukhin, Dmitry S.,Trifonov, Rostislav E.,Ostrovskii, Vladimir A.,Vasilyev, Aleksander V.

supporting information, p. 7020 - 7023 (2015/11/27)

Reactions of 5-substituted NH-tetrazoles with alcohols in the superacid CF3SO3H have been studied. Both the structure of the tetrazole and the nature of alcohol were found to dramatically influence the selectivity of the reaction and yields of products. Tetrazoles bearing phenyl, electron-donating aryl, or benzyl groups at the 5-position, have been alkylated using various alcohols (including MeOH and EtOH) in CF3SO3H upon heating at 60 °C for 0.3-12 h to afford 2-alkyl-2H-tetrazoles in 30-98% yields.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 153478-97-8