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CAS

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1539314-06-1

GSK-2881078, also known as a selective androgen receptor modulator (SARM), is a compound that selectively targets and modulates the activity of the androgen receptor. It has the ability to induce androgen receptor-mediated transcriptional activation in specific cell lines, such as PC3(AR)2 cells, with an EC50 value of 3.99 nM. The activity of GSK-2881078 can be inhibited by the non-steroidal androgen receptor antagonist bicalutamide. This selective modulation of the androgen receptor makes GSK-2881078 a promising candidate for various therapeutic applications.

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  • 1539314-06-1 Structure

  • Basic information

    1. Product Name: GSK-2881078
    2. Synonyms: GSK-2881078;GSK-2881078 (Free base)
    3. CAS NO:1539314-06-1
    4. Molecular Formula: C14H13F3N2O2S
    5. Molecular Weight: 330.33
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1539314-06-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 521.6±50.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.36±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: ≤20mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
    9. CAS DataBase Reference: GSK-2881078(CAS DataBase Reference)
    10. NIST Chemistry Reference: GSK-2881078(1539314-06-1)
    11. EPA Substance Registry System: GSK-2881078(1539314-06-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1539314-06-1(Hazardous Substances Data)

1539314-06-1 Usage

Uses

Used in Pharmaceutical Industry:
GSK-2881078 is used as a therapeutic agent for conditions that may benefit from selective androgen receptor modulation. Its agonistic properties in anabolic target tissues make it a potential candidate for the treatment of muscle wasting, osteoporosis, and other conditions related to muscle and bone health.
Used in Research Applications:
In the field of research, GSK-2881078 serves as a valuable tool for studying the role of androgen receptors in various biological processes. It can be used to investigate the mechanisms of androgen receptor activation and its effects on gene expression, cellular signaling, and tissue development.
Used in Drug Development:
GSK-2881078 can be utilized in the development of novel drugs targeting the androgen receptor. Its selective modulation of the receptor makes it a potential lead compound for the creation of new therapeutics with improved safety and efficacy profiles.
Used in Sports Performance Enhancement:
Due to its anabolic properties, GSK-2881078 may be investigated for its potential use in enhancing sports performance. However,

references

[1]. https://newdrugapprovals.org/2016/06/14/gsk-2881078/

Check Digit Verification of cas no

The CAS Registry Mumber 1539314-06-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,3,9,3,1 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1539314-06:
(9*1)+(8*5)+(7*3)+(6*9)+(5*3)+(4*1)+(3*4)+(2*0)+(1*6)=161
161 % 10 = 1
So 1539314-06-1 is a valid CAS Registry Number.

1539314-06-1Downstream Products

1539314-06-1Relevant articles and documents

CRYSTALLINE FORMS OF (R)-1 -(1-(METHYLSULFONYL)PROPAN-2-YL)-4-(TRIFLUOROMETHYL)INDOLINE-5-CARBONITRILE

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Page/Page column 30-31, (2015/08/06)

This invention relates to crystalline forms of (R)-1-(1-(methylsulfonyl)propan-2- yl)-4-(trifluoromethyl)indoline-5-carbonitrile, a modulator of the androgen receptor, and methods for the use in treatment.

INDOLECARBONITRILES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS

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, (2014/02/15)

This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

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