153936-26-6

Basic information

• Product Name: 2-AMINOMETHYL-3-METHYLPYRIDINE
• Synonyms: RARECHEM AL BW 0808;2-AMINOMETHYL-3-METHYLPYRIDINE;CHEMBRDG-BB 4003216;2-Aminmethyl-3-methylpyridine;2-Pyridinemethanamine,3-methyl-(9CI);(3-methylpyridin-2-yl)methylamine;(3-methylpyridin-2-yl)methanamine;3-Methyl-2-aminomethylpyridine
• CAS NO: 153936-26-6
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.17
• Product Categories: PYRIDINE;pharmacetical;Aminomethyl's;Pyridines
• Mol File: 153936-26-6.mol

Chemical Properties

• Boiling Point: 218.4±25.0℃ (760 Torr)
• Flash Point: 106.5±10.2℃
• Appearance: /
• Density: 1.027±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.126mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-AMINOMETHYL-3-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINOMETHYL-3-METHYLPYRIDINE(153936-26-6)
• EPA Substance Registry System: 2-AMINOMETHYL-3-METHYLPYRIDINE(153936-26-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 153936-26-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-AMINOMETHYL-3-METHYLPYRIDINE is used as an organic synthesis intermediate for the production of various chemical compounds. Its unique structure allows it to be a versatile building block in the synthesis of complex organic molecules, contributing to the development of new materials and chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-AMINOMETHYL-3-METHYLPYRIDINE is utilized as a pharmaceutical intermediate. It plays a crucial role in the development of new drugs and medicines, particularly in the synthesis of active pharmaceutical ingredients (APIs) that target specific biological pathways or receptors.
Used in Laboratory Research and Development:
2-AMINOMETHYL-3-METHYLPYRIDINE is also employed in laboratory research and development processes. It serves as a valuable compound for scientists and researchers to study its chemical properties, reactivity, and potential applications in various fields, including drug discovery and material science.
Used in Chemical Production Process:
Furthermore, 2-AMINOMETHYL-3-METHYLPYRIDINE is used in the chemical production process, where it is transformed into various chemical products through a series of chemical reactions. Its presence in the production process highlights its importance in the synthesis of a wide range of chemicals with diverse applications.

Synthesis

3-methyl-2-cyanopyridine (10 g, 84.6 mmol) was dissolved in ethanol (200 mL) at room temperature, Raney nickel (4 g) was added to the reaction substrate, And then stirred at room temperature under hydrogen in a hydrogen atmosphere overnight. To be completed, Filter solids, The organic solvent was removed by distillation under reduced pressure to give 3-methyl-2-aminomethylpyridine (9.7 g, yield 94%).

InChI:InChI=1/C7H10N2/c1-6-3-2-4-9-7(6)5-8/h2-4H,5,8H2,1H3/p+1

Upstream product

• 20970-75-6 2-cyano-3-methylpyridine 

Downstream Products

• 321435-43-2 (R)-3-((2S,4R)-4-Benzyl-5-oxo-tetrahydro-furan-2-carbonyl)-5,5-dimethyl-thiazolidine-4-carboxylic acid (3-methyl-pyridin-2-ylmethyl)-amide 
• 863548-24-7 N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-phenylpyrimidine-4-carboxamide 
• 1192345-52-0 N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-(2-fluorophenyl)pyrimidine-4-carboxamide 
• 1192345-54-2 N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-(3-fluorophenyl)pyrimidine-4-carboxamide 
• 1192345-56-4 N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-(2-chlorophenyl)pyrimidine-4-carboxamide 
• 863548-17-8 N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-(o-tolyl)pyrimidine-4-carboxamide 
• 863548-18-9 N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-(meta-tolyl)pyrimidine-4-carboxamide 
• 863548-19-0 N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-(p-tolyl)pyrimidine-4-carboxamide 
• 1192345-60-0 N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-(2-methoxyphenyl)pyrimidine-4-carboxamide 
• 1192345-62-2 N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-(4-methoxyphenyl)pyrimidine-4-carboxamide 
• 1192345-64-4 N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-(2-ethylphenyl)pyrimidine-4-carboxamide 
• 1192345-66-6 N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-(2-ethoxyphenyl)pyrimidine-4-carboxamide 
• 1192345-68-8 N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-(2-cyanophenyl)-pyrimidine-4-carboxamide 
• 863548-20-3 N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-(3'-cyanophenyl)-pyrimidine-4-carboxamide 

Relevant articles and documents

Preparation method of N- phenyl-2-aminopyrimidine compound and its application

The invention relates to a new N- phenyl-2-aminopyrimidine compound and a medicine composition containing the compound; the N- phenyl-2-aminopyrimidine compound is applied to treat related disease or symptoms of epidermal growth factor receptor (EGFR), such as treat or improve abnormal cell proliferative disease like cancer.

PRODUCTION METHOD OF OPTICALLY ACTIVE SECONDARY ALCOHOL

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A series of orexin receptor antagonists was synthesized based on a substituted piperidine scaffold. Through traditional medicinal chemistry structure-activity relationships (SAR), installation of various groups at the 3-6-positions of the piperidine led to modest enhancement in receptor selectivity. Compounds were profiled in vivo for plasma and brain levels in order to identify candidates suitable for efficacy in a model of drug addiction.

TACHYKININ RECEPTOR ANTAGONISTS

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