- Pyochelin Biosynthetic Metabolites Bind Iron and Promote Growth in Pseudomonads Demonstrating Siderophore-like Activity
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Pseudomonads employ several strategies to sequester iron vital for their survival including the use of siderophores such as pyoverdine and pyochelin. Similar in structure but significantly less studied are pyochelin biosynthetic byproducts, dihydroaeruginoic acid, aeruginoic acid, aeruginaldehyde (IQS), and aeruginol, along with two other structurally related molecules, aerugine and pyonitrins A-D, which have all been isolated from numerous Pseudomonad extracts. Because of the analogous substructure of these compounds to pyochelin, we hypothesized that they may play a role in iron homeostasis or have a biological effect on other bacterial species. Herein, we discuss the physiochemical evaluation of these molecules and disclose, for the first time, their ability to bind iron and promote growth in Pseudomonads.
- Kaplan, Anna R.,Musaev, Djamaladdin G.,Wuest, William M.
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p. 544 - 551
(2021/03/03)
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- The constitution and properties of a pyochelin-zinc complex
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The siderophore pyochelin, identified for the first time as a metabolite of Pseudomonas fluorescens, was isolated in highly pure form as a dimeric complex with two zinc atoms.The (1)H and (13)C magnetic resonance data for the two pyochelin moieties of the complex differ significantly from each other and from those of free pyochelin.The complex also exhibits unusual solubility and stability properties.Since it is easily isolable and can be readily converted into highly pure, free pyochelin, it offers an excellent entry to further biological studies on this important metabolite.
- Cuppels, Diane A.,Stipanovic, Robert D.,Stoessl, Albert,Stothers, J. B.
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p. 2126 - 2130
(2007/10/02)
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