27501-91-3

Basic information

• Product Name: 2-(2-Hydroxyphenyl)thiazole-4-carboxylic acid
• Synonyms: 2-(2-Hydroxyphenyl)-4-thiazolecarboxylic acid;2-(2-Hydroxyphenyl)thiazole-4-carboxylic acid;Aeruginoic acid
• CAS NO: 27501-91-3
• Molecular Formula: C₁₀H₇NO₃S
• Molecular Weight: 221.23
• Mol File: 27501-91-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-Hydroxyphenyl)thiazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Hydroxyphenyl)thiazole-4-carboxylic acid(27501-91-3)
• EPA Substance Registry System: 2-(2-Hydroxyphenyl)thiazole-4-carboxylic acid(27501-91-3)

Safety Data

• Hazardous Substances Data: 27501-91-3(Hazardous Substances Data)

Usage

Chemical Family

Thiazole family
2-(2-Hydroxyphenyl)thiazole-4-carboxylic acid is a part of the thiazole family of compounds.

Derivative

Thiazole with modifications
It is a derivative of thiazole, which has a carboxylic acid group and a hydroxyphenyl group attached to the thiazole ring.

Biological Activities

Antimicrobial and antifungal properties
The compound exhibits biological activities, such as being effective against microorganisms and fungi, making it potentially useful in pharmaceutical applications.

Synthesis Building Block

Used in the synthesis of various organic compounds
2-(2-Hydroxyphenyl)thiazole-4-carboxylic acid can be used as a building block for creating other organic compounds, expanding its applications in chemical research.

Structure and Properties

Valuable for medicinal and chemical research
The compound's unique structure and properties make it a valuable asset in the fields of medicinal and chemical research, contributing to the development of new compounds and therapies.

Upstream product

• 65-45-2 salicylamide 
• 115921-07-8 (R)-2-(2'-hydroxyphenyl)-4-methoxycarbonyl-4,5-dihydrothiazole 
• 611-20-1 salicylonitrile 
• 27501-92-4 methyl 2-(2-hydroxyphenyl)thiazole-4-carboxylate 
• 70-23-5 ethyl Bromopyruvate 
• 7133-90-6 2-hydroxythiobenzamide 
• 497-19-8 sodium carbonate 
• 83053-37-6 4-Dimethoxymethyl-2-(o-hydroxyphenyl)-thiazol 
• 83053-39-8 2'-(2-hydroxyphenyl)-2'-thiazole-4'-carboxaldehyde 
• 27383-13-7 ethyl 2-(2-hydroxyphenyl)thiazole-4-carboxylate 

Downstream Products

• 83053-39-8 2'-(2-hydroxyphenyl)-2'-thiazole-4'-carboxaldehyde 
• 828936-79-4 2'-(2-hydroxyphenyl)-2'-thiazole-4'-(N-methoxy-N-methyl)carboxamide 
• 154037-50-0 aeruginol 

Relevant articles and documents

Pyochelin Biosynthetic Metabolites Bind Iron and Promote Growth in Pseudomonads Demonstrating Siderophore-like Activity

Pseudomonads employ several strategies to sequester iron vital for their survival including the use of siderophores such as pyoverdine and pyochelin. Similar in structure but significantly less studied are pyochelin biosynthetic byproducts, dihydroaeruginoic acid, aeruginoic acid, aeruginaldehyde (IQS), and aeruginol, along with two other structurally related molecules, aerugine and pyonitrins A-D, which have all been isolated from numerous Pseudomonad extracts. Because of the analogous substructure of these compounds to pyochelin, we hypothesized that they may play a role in iron homeostasis or have a biological effect on other bacterial species. Herein, we discuss the physiochemical evaluation of these molecules and disclose, for the first time, their ability to bind iron and promote growth in Pseudomonads.

A highly selective fluorescent turn-on probe for Al3+ via Al3+-promoted hydrolysis of ester

A new reactive and highly selective fluorescent chemosensor (1) based on thiazole was synthesized for the quantification of aluminum ions in ethanol. The mechanism of fluorescence was based on the aluminum-promoted hydrolysis of the ester moiety and subse

N-tetrazolyl thiazolecarboxyamide derivatives and their use

Compounds of the formula: STR1 wherein A is a C1-6 alkyl group, an aryl group which is unsubstituted or substituted with at least one substituent selected from hydroxy, alkoxy, aryl-(C1-6)alkoxy, C1-6 alkylcarbonyloxy, halo-(C1-6)alkyl, halogen, nitro and amino, or 5- or 6-membered heterocyclic group containing at least one hetero atom selected from oxygen, nitrogen and sulfur, or a condensed heterocyclic group consisting of a heterocycle as defined above and a benzene nucleus, these two heterocyclic groups being unsubstituted or substituted with at least one substituent selected from hydroxy, C1-6 alkyl and halogen, and R is hydrogen or a C1-6 alkyl group, or a pharmaceutically acceptable salt thereof are nobel and useful as antiallergic.