27501-91-3Relevant academic research and scientific papers
Pyochelin Biosynthetic Metabolites Bind Iron and Promote Growth in Pseudomonads Demonstrating Siderophore-like Activity
Kaplan, Anna R.,Musaev, Djamaladdin G.,Wuest, William M.
, p. 544 - 551 (2021/03/03)
Pseudomonads employ several strategies to sequester iron vital for their survival including the use of siderophores such as pyoverdine and pyochelin. Similar in structure but significantly less studied are pyochelin biosynthetic byproducts, dihydroaeruginoic acid, aeruginoic acid, aeruginaldehyde (IQS), and aeruginol, along with two other structurally related molecules, aerugine and pyonitrins A-D, which have all been isolated from numerous Pseudomonad extracts. Because of the analogous substructure of these compounds to pyochelin, we hypothesized that they may play a role in iron homeostasis or have a biological effect on other bacterial species. Herein, we discuss the physiochemical evaluation of these molecules and disclose, for the first time, their ability to bind iron and promote growth in Pseudomonads.
Synthesis and Investigation of the Abiotic Formation of Pyonitrins A-D
Aniebok, Victor,Lee, Hsiau-Wei,Macmillan, John B.,Shingare, Rahul D.
, (2020/02/22)
Pyonitrins A-D are recently isolated natural products from the insect-associated Pseudomonas protegens strain, which were isolated from complex fractions that exhibited antifungal activity via an in vivo murine candidiasis assay. Genomic studies of Pseudomonas protegens suggested that pyonitrins A-D are formed via a spontaneous nonenzymatic reaction between biosynthetic intermediates of two well-known natural products pyochelin and pyrrolnitrin. Herein we have accomplished the first biomimetic total synthesis of pyonitrins A-D in three steps and studied the nonenzymatic formation of the pyonitrins using 15N NMR spectroscopy.
A highly selective fluorescent turn-on probe for Al3+ via Al3+-promoted hydrolysis of ester
Helal, Aasif,Kim, Sang Hyun,Kim, Hong-Seok
, p. 6095 - 6099 (2013/07/27)
A new reactive and highly selective fluorescent chemosensor (1) based on thiazole was synthesized for the quantification of aluminum ions in ethanol. The mechanism of fluorescence was based on the aluminum-promoted hydrolysis of the ester moiety and subse
N-tetrazolyl thiazolecarboxyamide derivatives and their use
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, (2008/06/13)
Compounds of the formula: STR1 wherein A is a C1-6 alkyl group, an aryl group which is unsubstituted or substituted with at least one substituent selected from hydroxy, alkoxy, aryl-(C1-6)alkoxy, C1-6 alkylcarbonyloxy, halo-(C1-6)alkyl, halogen, nitro and amino, or 5- or 6-membered heterocyclic group containing at least one hetero atom selected from oxygen, nitrogen and sulfur, or a condensed heterocyclic group consisting of a heterocycle as defined above and a benzene nucleus, these two heterocyclic groups being unsubstituted or substituted with at least one substituent selected from hydroxy, C1-6 alkyl and halogen, and R is hydrogen or a C1-6 alkyl group, or a pharmaceutically acceptable salt thereof are nobel and useful as antiallergic.
2-Phenylthiazole Derivatives from Pseudomonas cepacia
Bukovits, G. J.,Mohr, N.,Budzikiewicz, H.,Korth, H.,Pulverer, G.
, p. 877 - 880 (2007/10/02)
From the culture medium of Pseudomonas cepacia 2-(o-hydroxyphenyl)-thiazol and its 4-carbaldehyd and 4-carboxylic acid derivatives (aeruginoic acid) could be isolated.Their structures were elucidated and confirmed by synthesis. - Key words: Phenylthiazols, Bacterial Metabolites, Pseudomonas cepacia, Mass Spectra
