154386-35-3

Basic information

• Product Name: 2-HYDROXY-6-METHOXY-QUINOLINE-3-CARBOXYLIC ACID
• Synonyms: 3-Quinolinecarboxylic acid, 1,2-dihydro-6-methoxy-2-oxo-;6-Methoxy-1,2-dihydro-2-oxo-3-quinolinecarboxylic acid
• CAS NO: 154386-35-3
• Molecular Formula: C11H9NO4
• Molecular Weight: 219.2
• Mol File: 154386-35-3.mol

Chemical Properties

• Boiling Point: 479.1°Cat760mmHg
• Flash Point: 243.5°C
• Appearance: /
• Density: 1.402g/cm³
• Vapor Pressure: 5.48E-10mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: 2-8°C
• PKA: 2.28±0.20(Predicted)
• CAS DataBase Reference: 2-HYDROXY-6-METHOXY-QUINOLINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-6-METHOXY-QUINOLINE-3-CARBOXYLIC ACID(154386-35-3)
• EPA Substance Registry System: 2-HYDROXY-6-METHOXY-QUINOLINE-3-CARBOXYLIC ACID(154386-35-3)

Safety Data

• Hazardous Substances Data: 154386-35-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-6-methoxy-quinoline-3-carboxylic acid is used as a pharmaceutical intermediate for the development of new drugs. Its unique structure and functional groups make it a promising candidate for the synthesis of various medicinal compounds with potential therapeutic applications.
Used in Medicinal Chemistry Research:
2-Hydroxy-6-methoxy-quinoline-3-carboxylic acid is utilized as a key component in the design and synthesis of novel compounds with potential biological activities. Its presence in various chemical libraries allows researchers to explore its interactions with biological targets and evaluate its efficacy in treating specific diseases or conditions.

InChI:InChI=1/C11H9NO4/c1-16-7-2-3-9-6(4-7)5-8(11(14)15)10(13)12-9/h2-5H,1H3,(H,12,13)(H,14,15)

Upstream product

• 123990-78-3 6-methoxy-2-oxo-1,2-dihydroquinolin-3-carboxaldehyde 
• 26831-52-7 2-amino-5-methoxybenzaldehyde 
• 1260652-10-5 ethyl 6-methoxy-2-oxo-1,2-dihydroquinoline-3-carboxylate 
• 588-16-9 m-methoxyacetanilide 
• 73568-29-3 2-chloro-6-methoxyquinolin-3-carboxaldehyde 
• 137612-85-2 2-chloro-6-methoxyquinoline-3-carboxylic acid 

Relevant articles and documents

FLUORESCENT DYE AGENT AND CARBOSTYRIL COMPOUND

PROBLEM TO BE SOLVED: To provide a novel fluorescent dye agent. SOLUTION: A fluorescent dye agent contains a carbostyril compound represented by formula (1) [in the formula (1), R1 is H, a halogen atom, a hydroxyl group, a cyano group, a nitro group or the like; R2 is O; R3 is a halogen atom, a carboxyl group, an ester group, an amide group or the like; R4-R6 and R8 independently represent H, a halogen atom, a nitro group, a cyano group or the like, where mutually adjacent groups of R4-R8 may be bound to form a ring; R7 is H, a substituted or unsubstituted aliphatic group or the like]. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Design, synthesis and evaluation of 3-quinoline carboxylic acids as new inhibitors of protein kinase CK2

In this article, the derivatives of 3-quinoline carboxylic acid were studied as inhibitors of protein kinase CK2. Forty-three new compounds were synthesized. Among them 22 compounds inhibiting CK2 with IC50 in the range from 0.65 to 18.2 μM were identified. The most active inhibitors were found among tetrazolo-quinoline-4-carboxylic acid and 2-aminoquinoline-3-carboxylic acid derivatives.

Synthesis of dibenzonaphthyridin-6(5H-)ones

Substituted dibenzonaphthyridin-6(5H)-ones (5a-g) have been synthesized by treating various 2-oxoquinoline--3-carboxanilides (4a-g) with polyphosphoric acid.The precursors have been readily obtained by the condensation of 2-quinoline-3-carboxyli