154467-16-0

Basic information

• Product Name: N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate
• Synonyms: N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate;N-(2-AMinoethyl)-4-MorpholinecarboxaMide ethanedio;N-(2-AMinoethyl)-4-MorpholinecarboxaMide;N-(2-aMinoethyl)-4-MorpholinecarboxaMide oxalate;N-(2-AMinoethyl)Morpholine-4-carboxaMide oxalate;Landiolol HCl PI-3
• CAS NO: 154467-16-0
• Molecular Formula: C₂H₂O₄*C₇H₁₅N₃O₂
• Molecular Weight: 263.25
• EINECS: 1308068-626-2
• Mol File: 154467-16-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate(154467-16-0)
• EPA Substance Registry System: N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate(154467-16-0)

Safety Data

• Hazardous Substances Data: 154467-16-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate is used as an antineoplastic agent for its significant antitumor activity, making it a potential candidate for cancer treatment. Its ability to target and inhibit the growth of cancer cells positions it as a valuable asset in the fight against various types of cancer.
Used in Antiviral Applications:
In the field of antiviral research and treatment, N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate is utilized for its potent antiviral activity against human cytomegalovirus and influenza A virus. This capability highlights its potential in developing treatments for viral infections, particularly those that are resistant to existing antiviral medications.
Used in Drug Development:
N-(2-Aminoethyl)-4-morpholinecarboxamide ethanedioate is employed as a key compound in the development of new pharmaceuticals targeting both cancer and viral diseases. Its unique properties and proven effectiveness in preclinical studies make it an attractive candidate for further research and potential incorporation into novel therapeutic agents.

InChI:InChI=1/C7H15N3O2.C2H2O4/c8-1-2-9-7(11)10-3-5-12-6-4-10;3-1(4)2(5)6/h1-6,8H2,(H,9,11);(H,3,4)(H,5,6)

Upstream product

• 144-62-7 oxalic acid 
• 93605-74-4 4-[(1H-imidazol-1-yl)carbonyl]morpholine 
• 107-15-3 ethylenediamine 

Downstream Products

• 133242-30-5 2,2-dimethyl-1,3-dioxolan-4S-ylmethyl 3-<4-<3-<2-(morpholinocarbonylamino)ethylamino>-2S-hydroxypropoxy>phenyl>propionate 
• 144481-98-1 Landiolol hydrochloride 
• 69630-16-6 N-(2-aminoethyl)-4-morpholine carboxamide 
• 1253907-79-7 landiolol hydrochloride 

Relevant articles and documents

Preparation method of landiolol hydrochloride intermediate

The invention discloses a preparation method of a high-purity landiolol hydrochloride intermediate N-(2-aminoethyl)-4-morpholinecarboxamide oxalate. The preparation method comprises the following steps: reacting N-phenoxy carbonyl morpholine with ethylenediamine, concentrating the reaction liquid, adding a solvent for dissolving, adjusting the pH value to 9-14 by using alkali, filtering to remove solid byproducts, concentrating the filtrate to obtain N-(2-aminoethyl)-4-morpholine formamide, adding water for dissolving, adjusting the pH value to 1-6 by using oxalic acid, filtering to remove a small amount of ethylenediamine oxalate solid, concentrating the filtrate, adding a solvent, and recrystallizing to obtain the high-purity N-(2-aminoethyl)-4-morpholinecarboxamide oxalate. According to the method, the high-purity landiolol hydrochloride intermediate can be obtained, the defects that the byproduct sodium phenate is difficult to filter, ethylenediamine is easy to remain and the like are overcome, the process is stable and controllable, the solvent can be recycled, and the method is more suitable for industrial production.

Preparation method of landiolol hydrochloride

The invention provides a preparation method of landiolol hydrochloride. The preparation method utilizes cheap and easily available raw materials. A key reaction utilizes a phase transfer catalysis method so reaction time is shortened. The preparation meth