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1,6-Naphthyridin-5(6H)-one,7,8-dihydro-(9CI) is a heterocyclic organic compound with the molecular formula C10H8N2O. It belongs to the naphthyridine class of compounds and features a fused-ring structure with a naphthyridine core. As a dihydro derivative, it contains two hydrogen atoms within its molecular structure. This chemical is of interest to chemists and researchers in the field due to its unique properties and potential applications.

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  • 155058-02-9 Structure
  • Basic information

    1. Product Name: 1,6-Naphthyridin-5(6H)-one,7,8-dihydro-(9CI)
    2. Synonyms: 1,6-Naphthyridin-5(6H)-one,7,8-dihydro-(9CI);7,8-dihydro-1,6-naphthyridin-5(6H)-one;N-methyl-1-(1-methylpiperidin-4-yl)-2-(pyrrolidin-1-yl)ethanamine;1,6-Naphthyridin-5(6H)-one, 7,8-dihydro-;7,8-Dihydro-6H-[1,6]naphthyridin-5-one
    3. CAS NO:155058-02-9
    4. Molecular Formula: C8H8N2O
    5. Molecular Weight: 148.164
    6. EINECS: N/A
    7. Product Categories: PYRIDINE
    8. Mol File: 155058-02-9.mol
  • Chemical Properties

    1. Melting Point: 163-166 °C(Solv: ethyl acetate (141-78-6))
    2. Boiling Point: 413.9±34.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.214±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. PKA: 13.28±0.20(Predicted)
    10. CAS DataBase Reference: 1,6-Naphthyridin-5(6H)-one,7,8-dihydro-(9CI)(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1,6-Naphthyridin-5(6H)-one,7,8-dihydro-(9CI)(155058-02-9)
    12. EPA Substance Registry System: 1,6-Naphthyridin-5(6H)-one,7,8-dihydro-(9CI)(155058-02-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 155058-02-9(Hazardous Substances Data)

155058-02-9 Usage

Uses

Used in Organic Synthesis:
1,6-Naphthyridin-5(6H)-one,7,8-dihydro-(9CI) is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure and reactivity make it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1,6-Naphthyridin-5(6H)-one,7,8-dihydro-(9CI) is used as a starting material or intermediate in the development of new drugs. Its heterocyclic nature and potential for functionalization make it a promising candidate for the design of novel therapeutic agents with unique mechanisms of action.
Used in Chemical Research:
1,6-Naphthyridin-5(6H)-one,7,8-dihydro-(9CI) is also utilized in chemical research to study the properties and reactivity of naphthyridine-based compounds. This research can lead to a better understanding of the structure-activity relationships in this class of compounds and facilitate the discovery of new applications in various fields, including materials science and catalysis.

Check Digit Verification of cas no

The CAS Registry Mumber 155058-02-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,5,0,5 and 8 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 155058-02:
(8*1)+(7*5)+(6*5)+(5*0)+(4*5)+(3*8)+(2*0)+(1*2)=119
119 % 10 = 9
So 155058-02-9 is a valid CAS Registry Number.

155058-02-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 7,8-dihydro-6H-1,6-naphthyridin-5-one

1.2 Other means of identification

Product number -
Other names Y7639

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:155058-02-9 SDS

155058-02-9Relevant articles and documents

INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

-

, (2022/02/05)

Provided herein are compounds of formula (V) that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

INHIBITOR OF BTK AND MUTANTS THEREOF

-

, (2020/09/12)

The disclosure includes compounds of Formula (I) (1) wherein Q0, Q1, Q2, Q3, Q4, Z, W, i, j, m, n, Warhead, R0, R1, R3, R4, R5, R6, and R7, are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.

PRMT5 INHIBITORS AND USES THEREOF

-

, (2016/04/20)

Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof:wherein Y1 is of formula (?) or formula (y):Ring Y is a 5- to 6-membered heteroaryl ring; and V4, V5, Rx, x, y, and n are as defined herein. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2

Galli, Ubaldina,Mesenzani, Ornella,Coppo, Camilla,Sorba, Giovanni,Canonico, Pier Luigi,Tron, Gian Cesare,Genazzani, Armando A.

, p. 58 - 66,9 (2020/07/31)

As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogues of nicotinamide. Biological data suggest that compound 2 is selective for Sirt3 over Sirt1 and Sirt2.

Efficacy switching SAR of mGluR5 allosteric modulators: Highly potent positive and negative modulators from one chemotype

Sams, Anette Graven,Mikkelsen, Gitte Kobber?e,Brodbeck, Robbin M.,Pu, Xiaosui,Ritzén, Andreas

, p. 3407 - 3410 (2011/07/07)

A series of metabotropic glutamate 5 receptor (mGluR5) allosteric ligands with positive, negative or no modulatory efficacy is described. The ability of this series to yield both mGluR5 PAMs and NAMs with single-digit nanomolar potency is unusual, and the

Ready access to 7,8-dihydro- and 1,2,3,4-tetrahydro-1,6-naphthyridine-5(6H) -ones from simple pyridine precursors

Showalter, H. D. Hollis

, p. 1311 - 1317 (2007/10/03)

Short pathways are described for the synthesis of a representative example of each of the 7,8-dihydro- and 1,2,3,4-tetrahydro-1,6-naphthyridine-5(6H)-one ring systems from simple pyridine precursors. An attempted synthesis of the related 4,6-dihydro-1,6-naphthyridin-5(1H)-one ring system from a common intermediate was unsuccessful.

Dihydro- and tetrahydronaphthyridines

-

, (2008/06/13)

This invention concerns novel dihydro- and tetrahydronaphthyridines useful for enhancing the lethal effects on tumor cells to treatment causing DNA-damaging activity as with ionizing radiation or with a chemotherapeutic agent.

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