155527-97-2

Basic information

• Product Name: 4-[4-(dimethylamino)benzylidene]-3-phenyl-5(4H)-isoxazolone
• Synonyms: 4-[4-(dimethylamino)benzylidene]-3-phenyl-5(4H)-isoxazolone;(4Z)-4-[4-(dimethylamino)benzylidene]-3-phenyl-1,2-oxazol-5(4H)-one
• CAS NO: 155527-97-2
• Molecular Formula: C18H16N2O2
• Molecular Weight: 292.33184
• Mol File: 155527-97-2.mol

Chemical Properties

• Boiling Point: 451.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• PKA: 3.69±0.24(Predicted)
• CAS DataBase Reference: 4-[4-(dimethylamino)benzylidene]-3-phenyl-5(4H)-isoxazolone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(dimethylamino)benzylidene]-3-phenyl-5(4H)-isoxazolone(155527-97-2)
• EPA Substance Registry System: 4-[4-(dimethylamino)benzylidene]-3-phenyl-5(4H)-isoxazolone(155527-97-2)

Safety Data

• Hazardous Substances Data: 155527-97-2(Hazardous Substances Data)

Upstream product

• 127916-11-4 ethyl bezoylacetate oxime 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 
• 889-37-2 N,N-dimethyl-4-((phenylimino)methyl)aniline 
• 23253-51-2 3-phenyl-5-hydroxyisoxazole 
• 7713-79-3 3-phenyl-5-isoxazolone 

Relevant articles and documents

Facile and expedient synthesis of α,β-unsaturated isoxazol-5(4H)-ones under mild conditions

Abstract: It was found that nano-SiO2–H2SO4 was catalyzed by the three-component cyclocondensation of aryl/heteroaryl aldehydes, hydroxylamine hydrochloride, and β-ketoesters toward the synthesis of α,β-unsaturated?isoxazol-5(4H)-ones under green conditions. The reaction yielded the corresponding heterocycles at room temperature in relatively shorter reaction times. It merits mentioning that the mild conditions allow the synthesis of several α,β-unsaturated?isoxazol-5(4H)-ones using this method. In this study, some new derivatives of isoxazolones were also synthesized and characterized. It is efficient, clean, simple, safe, and ecologically friendly. This straightforward method is cost-effective and requires no preparation of reactants. The three-component annulation was performed without using energy sources, for example, heat, ultrasound wave, and microwave irradiation. Graphic abstract: [Figure not available: see fulltext.].

One-pot green synthesis of isoxazol-5(4H)-one derivatives using Dowex1-x8OH in water

4-(Arylmethylidene)-3-methylisoxazol-5(4H)-ones and 4-(arylmethylidene)-3-phenylisoxazol-5(4H)-ones were synthesized in a one-pot three-component procedure in the presence of Dowex1-x8OH as catalyst in water. The products were obtained in high yields (90-

Nano Fe2O3, clinoptilolite and H3PW12O40 as efficient catalysts for solvent-free synthesis of 5(4H)-isoxazolone under microwave irradiation conditions

A quick and solvent-free approach involving the exposure of neat reactants to microwave irradiation in conjunction with the use of clinoptilolite, H3PW12O40 and Fe2O3 nanoparticle catalysts is described. In this work, condensation of hydroxylamine hydroch

Fast and efficient synthesis of 4-arylidene-3-phenylisoxazol-5-ones

A convenient and easy synthesis of 4-arylidene-3-phenylisoxazol-5-ones by the three-component reaction of hydroxylamine, ethyl benzoylacetate and aromatic aldehydes in the presence of DABCO in refluxing ethanol is reported.

The convenient synthesis of 4-arylmethylidene-4,5-dihydro-3-phenylisoxazol- 5-ones

4-Arylmethylidene-4,5-dihydro-3-phenylisoxazol-5-ones were synthesized by the convenient three-component reaction of ethyl benzoylacetate, hydroxylamine and aromatic aldehydes in the presence of pyridine. The target compounds were also obtained by the rea

New Aspects in the Reaction of Azomethines with Cyclic CH-Acidic Compounds

Treatment of substituted benzylidene anilines 1a - f with cyclic CH-acidic compounds 2a - m in ethanol at room temperature yields in addition/elimination reactions the corresponding arylidene derivatives 4 and the 2:1 adducts 5.The addition products 3, which are formed as intermediates, could not be isolated in any case.The donor/acceptor effect of the substituents on the benzylidene moiety influences to a significant extent the reactivity towards the azomethine carbon. Keywords.Azomethine; CH-Acidic compound; Addition/elimination reaction.