155778-84-0

Basic information

• Product Name: 4-(4-methylpiperazin-1-yl)cyclohexanone
• Synonyms: 4-(4-methylpiperazin-1-yl)cyclohexanone;4-(4-Methyl-1-piperazinyl)-cyclohexanone;4-(4-METHYLPIPERAZIN-1-YL)CYCLOHEXAN-1-ONE
• CAS NO: 155778-84-0
• Molecular Formula: C₁₁H₂₀N₂O
• Molecular Weight: 196.2893
• Mol File: 155778-84-0.mol

Chemical Properties

• Boiling Point: 302.4±37.0 °C(Predicted)
• Appearance: colorless liquid
• Density: 1.060±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.09±0.42(Predicted)
• CAS DataBase Reference: 4-(4-methylpiperazin-1-yl)cyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methylpiperazin-1-yl)cyclohexanone(155778-84-0)
• EPA Substance Registry System: 4-(4-methylpiperazin-1-yl)cyclohexanone(155778-84-0)

Safety Data

• Hazardous Substances Data: 155778-84-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(4-methylpiperazin-1-yl)cyclohexanone is used as an intermediate for the synthesis of azaindole derivatives. These derivatives are known to act as c-Jun N-terminal kinase (JNK) inhibitors, which play a significant role in the treatment of various diseases. By inhibiting JNK, these derivatives can potentially modulate cellular signaling pathways involved in inflammation, cell proliferation, and apoptosis, offering therapeutic benefits for patients.
Used in Research and Development:
In addition to its pharmaceutical applications, 4-(4-methylpiperazin-1-yl)cyclohexanone is also utilized in research and development for the discovery and optimization of new drug candidates. Its unique chemical properties make it a valuable tool for exploring novel chemical space and developing innovative therapeutic strategies.

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 109-01-3 1-methyl-piperazine 
• 155778-83-9 4-(1,4-dioxaspiro<4,5>dec-8-yl)-1-methylpiperazine 

Downstream Products

• 155778-86-2 C₂₆H₄₄Cl₂N₆ 
• 155778-85-1 1,4-bis-<4-(4-methyl-piperazin-1-yl)-cyclohexen-1-yl>-piperazine 

Relevant articles and documents

THE USE OF 7-AZAINDOLES IN THE INHIBITION OF C-JUN N-TERMINAL KINASE

The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and

7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE

The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof, the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and the use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of said compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them

FUNCTIONALIZED CHLOROENAMINES IN AMINOCYCLOPROPANE SYNTHESIS-XIV. AMINOANNULATED CYCLOPROPANES-RIGID BUILDING BLOCKS FOR OLIGOAMINES

Sterically pure meander oligoamines 5 possessing bicyclohexyl moieties as rigid building blocks were synthesized from monoketal 9 via di(chloroenamine) 14, bicyclic diketones 16 and subsequent reductive amination of 16.Use of the same reactions and