155778-83-9

Usage

Uses

Used in Pharmaceutical Industry:
1-methyl-4-(1,4-dioxaspiro[4.5]decan-8-yl)piperazine is used as a building block for the development of drugs due to its unique structure and properties that can be leveraged for various therapeutic purposes. Its potential applications in medicine make it a promising candidate for further research and development in drug discovery processes.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 127562-53-2 4-(1,4-dioxaspiro<4.5>dec-8-yl)morpholine 

Downstream Products

• 155778-86-2 C₂₆H₄₄Cl₂N₆ 
• 155778-85-1 1,4-bis-<4-(4-methyl-piperazin-1-yl)-cyclohexen-1-yl>-piperazine 
• 155778-84-0 4-(4-methyl-piperazin-1-yl)-cyclohexanone 

Relevant academic research and scientific papers

Polymer-supported triacetoxyborohydride: A novel reagent of choice for reductive amination

A novel polymer-supported triacetoxyborohydride reagent for reductive amination of aldehydes and ketones is reported. The bound reagent was found to be shelf-stable and provided broad scope and reactivity in reductive amination reactions under mild reacti

Compositions for reductive aminations utilizing supported tricarboxyborohydride reagents and methods of using the same

A modified solid-support for use as a supported reagent for use in reduction reactions, including reductive amination comprising a solid-support having an tetrasubstituted ammonium cation species ionically bonded to a borohydride anion species extending therefrom having the general formula: wherein P is a solid-support, S is a spacer group selected from the group consisting of alkylene, {including —(CH2)n—}, alkyleneoxy {including -0(CH2)n—}, alkylenethio {including —S(CH2)n—} and alkylenecarboxy, {including —O(O)C—(CH2)n—}, n=2-16. R1, R2, R3 and R are each independently selected from the group consisting of alkyl, cycloalkyl, haloalkyl and aryl. Y equals 1, 2 or 3. H is hydrogen or deuterium.

7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE

The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof, the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and the use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of said compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them

THE USE OF 7-AZAINDOLES IN THE INHIBITION OF C-JUN N-TERMINAL KINASE

The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and

FUNCTIONALIZED CHLOROENAMINES IN AMINOCYCLOPROPANE SYNTHESIS-XIV. AMINOANNULATED CYCLOPROPANES-RIGID BUILDING BLOCKS FOR OLIGOAMINES

Sterically pure meander oligoamines 5 possessing bicyclohexyl moieties as rigid building blocks were synthesized from monoketal 9 via di(chloroenamine) 14, bicyclic diketones 16 and subsequent reductive amination of 16.Use of the same reactions and