155790-12-8

Basic information

• Product Name: 6-methyl-2-(methylamino)nicotinic acid
• Synonyms: 6-methyl-2-(methylamino)nicotinic acid
• CAS NO: 155790-12-8
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.179
• Mol File: 155790-12-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-methyl-2-(methylamino)nicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-2-(methylamino)nicotinic acid(155790-12-8)
• EPA Substance Registry System: 6-methyl-2-(methylamino)nicotinic acid(155790-12-8)

Safety Data

• Hazardous Substances Data: 155790-12-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
6-methyl-2-(methylamino)nicotinic acid is utilized as a key intermediate in the synthesis of various pharmaceuticals, leveraging its unique structural features to contribute to the development of new drugs and therapeutic agents.
Used in Medicinal Applications:
In the field of medicine, 6-methyl-2-(methylamino)nicotinic acid is studied for its potential biological activities, such as antioxidant, anti-inflammatory, and neuroprotective properties, which may contribute to the treatment and management of various diseases and conditions.
Used in Drug Development:
6-methyl-2-(methylamino)nicotinic acid serves as a building block in drug development, providing a foundation for the creation of innovative and effective medications that can address unmet medical needs and improve patient outcomes across different therapeutic areas.

Upstream product

• 30529-70-5 2-chloro-6-methyl nicotinic acid 
• 74-89-5 methylamine 

Relevant articles and documents

Iridium-catalyzed enantioselective addition of an: N -methyl C-H bond to α-trifluoromethylstyrenes via C-H activation

The Ir-catalyzed enantioselective addition of an N-methyl C-H bond of 2-(methylamino)pyridine derivatives to α-trifluoromethylstyrenes proceeded via C-H activation to give chiral γ-branched amine derivatives having a trifluoromethyl-substituted stereocenter. It was found that a bulky and electron-withdrawing group at the 3-position of 2-(methylamino)pyridines was necessary for the present C-H addition reaction catalyzed by a cationic iridium/chiral bisphosphine complex.

AMIDE COMPOUNDS

A compound of the formula (I) wherein R1 is hydrogen, lower alkyl, lower alkenyl, halo(lower)alkyl, cyclo(lower)alkyl, lower alkoxy, lower alkylthio, acyl, optionally substituted aryl or NR3R4; R2 is hydrogen; or aryl or heteroaryl, each of which may be substituted; X is direct bond or bivalent residue derived from piperazine; Y is -(A1)n#191-(A2?)?m#191-, wherein n and m are independently 0 or 1); is bivalent residue derived from arene or heteroarene; and is bivalent residue derived from arene or heteroarene, or a salt thereof. The compound of the present invention and a salt thereof inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.

SYNTHESIS OF THE MUTAGENIC 2-AMINO-1,6-DIMETHYLIMIDAZOPYRIDINE (1,6-DMIP) AND FIVE OF ITS ISOMERS

Synthetic routes to 2-amino-1,6-dimethylimidazopyridine and its 1,5-, 1,7-, 3,5- 3,6- and 3,7-dimethyl isomers from methyl derivatives of 3-hydroxy- or 2-amino-pyridine and 2-chloronicotinic acid are described.