156150-67-3

Basic information

• Product Name: 3-CHLORO-4-FLUOROIODOBENZENE
• Synonyms: 2-Chloro4-iodofluorobenzene;2-Chloro-1-fluoro-4-iodobenzene,99%;3-Chloro-4-fluoroiodobenzene;4-Fluoro-3-chloroiodobenzene;2-Chloro-4-iodo-1-fluorobenzene;3-CHLORO-4-FLUOROIODOBENZENE;2-CHLORO-1-FLUORO-4-IODOBENZENE;3-Chloro-4-fluoro-1-iodobenzene
• CAS NO: 156150-67-3
• Molecular Formula: C₆H₃ClFI
• Molecular Weight: 256.44
• EINECS: -0
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Chlorine Compounds;Fluorine Compounds;Iodine Compounds;Aryl;C6;Halogenated Hydrocarbons;Aryl Fluorinated Building Blocks;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;alkyl Iodine| alkyl chloride| alkyl Fluorine
• Mol File: 156150-67-3.mol

Chemical Properties

• Boiling Point: 94-95 °C15 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colourless to light yellow liquid
• Density: 2.008 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.157mmHg at 25°C
• Refractive Index: n20/D 1.604(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform
• Water Solubility: Slightly soluble in water.
• Sensitive: Light Sensitive
• CAS DataBase Reference: 3-CHLORO-4-FLUOROIODOBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-FLUOROIODOBENZENE(156150-67-3)
• EPA Substance Registry System: 3-CHLORO-4-FLUOROIODOBENZENE(156150-67-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 156150-67-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-4-fluoroiodobenzene is used as a CDK2 inhibitor for enzyme inhibitory activity. It serves as a crucial component in the development of pharmaceuticals targeting specific enzymes, which can be beneficial in treating various diseases and conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-chloro-4-fluoroiodobenzene may be used in the preparation of 2-chloro-1-(3,5-dimethoxyphenoxy)-4-iodobenzene. This is achieved by reacting it with 3,5-dimethoxyphenol in the presence of cesium carbonate, which is an essential step in the synthesis of various organic compounds.
Used in the Synthesis of 3-Carboxythiophene Analogs:
3-Chloro-4-fluoroiodobenzene also participates in the synthesis of 3-carboxythiophene analogs, which are important intermediates in the production of various organic compounds and materials. Its unique structure and reactivity make it a valuable component in this process.

InChI:InChI=1/C6H3ClFI/c7-5-2-1-4(9)3-6(5)8/h1-3H

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 
• 350-30-1 3-chloro-4-fluoronitrobenzene 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 462-06-6 fluorobenzene 
• 348-51-6 1-chloro-2-fluorobenzene 
• 71-43-2 benzene 
• 718628-28-5 3'-chloro-4'-fluoro[1,1'-biphenyl]-4-carbaldehyde 
• 306297-99-4 C₁₃H₁₄ClFO₂ 
• 866686-85-3 3-chloro-5-(3-chloro-4-fluorophenylethynyl)-pyridine 
• 866685-80-5 3-(3-chloro-4-fluorophenylethynyl)-5-methoxypyridine 
• 866685-08-7 5-(3-chloro-4-fluorophenylethynyl)-nicotinonitrile 
• 915001-95-5 (S)-3-(3-chloro-4-fluorophenylamino)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1043902-15-3 5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-(3-chloro-4-fluorophenyl)-2,2-dimethylfuran-3(2H)-one 
• 1056452-45-9 C₂₃H₂₀ClFN₂O₄ 
• 1056452-44-8 C₂₉H₂₂Cl₂F₂N₂O₄ 
• 1187324-91-9 ethyl 1-(3-chloro-4-fluorophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylate 
• 1150542-40-7 C₁₄H₁₈ClFSi 

Relevant articles and documents

Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.