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CAS

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1566577-46-5

(E)-5-((dimethylamino)methylene)-1-(4-fluorophenyl)pyrimidine-2,4,6-trione is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1566577-46-5 Structure

  • Basic information

    1. Product Name: (E)-5-((dimethylamino)methylene)-1-(4-fluorophenyl)pyrimidine-2,4,6-trione
    2. Synonyms: (E)-5-((dimethylamino)methylene)-1-(4-fluorophenyl)pyrimidine-2,4,6-trione
    3. CAS NO:1566577-46-5
    4. Molecular Formula:
    5. Molecular Weight: 277.255
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1566577-46-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (E)-5-((dimethylamino)methylene)-1-(4-fluorophenyl)pyrimidine-2,4,6-trione(CAS DataBase Reference)
    10. NIST Chemistry Reference: (E)-5-((dimethylamino)methylene)-1-(4-fluorophenyl)pyrimidine-2,4,6-trione(1566577-46-5)
    11. EPA Substance Registry System: (E)-5-((dimethylamino)methylene)-1-(4-fluorophenyl)pyrimidine-2,4,6-trione(1566577-46-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1566577-46-5(Hazardous Substances Data)

1566577-46-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1566577-46-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,6,6,5,7 and 7 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1566577-46:
(9*1)+(8*5)+(7*6)+(6*6)+(5*5)+(4*7)+(3*7)+(2*4)+(1*6)=215
215 % 10 = 5
So 1566577-46-5 is a valid CAS Registry Number.

1566577-46-5Relevant articles and documents

Discovery of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 5-(aminomethylene)pyrimidine-2,4,6-trione moiety as c-Met kinase inhibitors

Tang, Qidong,Zhang, Guogang,Du, Xinming,Zhu, Wufu,Li, Ruijuan,Lin, Huafang,Li, Pengcheng,Cheng, Maosheng,Gong, Ping,Zhao, Yanfang

, p. 1236 - 1249 (2014/03/21)

A series of novel quinoline derivatives bearing 5-(aminomethylene) pyrimidine-2,4,6-trione moiety were designed, synthesized, and evaluated for their c-Met kinase inhibitory activities and antiproliferative activities against 5 cancer cell lines (HT-29, H460, MKN-45, A549, and U87MG) in vitro. Most compounds showed moderate to excellent potency, with the most promising analogue 45 (c-Met half-maximal inhibitory concentration [IC50] = 1.15 nM) showing high selectivity versus 5 other tyrosine kinases, VEGFR-2, Flt-3, PDGFR-β, c-Kit, and EGFR. Structure-activity relationship studies indicated that electron-donating groups on the phenyl ring at the 3-position of pyrimidine-2,4,6-trione were required to increase the electron density on the 5-(aminomethylene)pyrimidine-2,4,6-trione moiety.

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