19136-41-5

Basic information

• Product Name: 1-(4-fluorophenyl)pyrimidine-2,4,6-trione
• Synonyms: 1-(4-fluorophenyl)pyrimidine-2,4,6-trione
• CAS NO: 19136-41-5
• Molecular Weight: 222.176
• Mol File: 19136-41-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-fluorophenyl)pyrimidine-2,4,6-trione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)pyrimidine-2,4,6-trione(19136-41-5)
• EPA Substance Registry System: 1-(4-fluorophenyl)pyrimidine-2,4,6-trione(19136-41-5)

Safety Data

• Hazardous Substances Data: 19136-41-5(Hazardous Substances Data)

Usage

Chemical class

Pyrimidine derivative

Pharmaceutical application

Potential anti-inflammatory and analgesic agent

Enzyme inhibition

Exhibits inhibitory activity against certain enzymes and biological processes

Structural features

Fluorophenyl substituent

Research and development

Promising candidate in the field of medicinal chemistry

Drug design and synthesis

Utilized for targeted therapeutic applications due to specific properties of the fluorophenyl substituent

Upstream product

• 659-30-3 1-(4-fluorophenyl)urea 
• 108-59-8 malonic acid dimethyl ester 
• 371-40-4 4-fluoroaniline 
• 105-53-3 diethyl malonate 

Downstream Products

• 1566577-46-5 (E)-5-((dimethylamino)methylene)-1-(4-fluorophenyl)pyrimidine-2,4,6-trione 
• 1566577-70-5 1-(4-fluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1566577-78-3 1-(4-fluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-morpholinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)trione 
• 1566577-86-3 1-(4-fluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinoline-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1566577-54-5 1-(4-fluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1566577-62-5 1-(4-fluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 

Relevant articles and documents

Discovery of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 5-(aminomethylene)pyrimidine-2,4,6-trione moiety as c-Met kinase inhibitors

A series of novel quinoline derivatives bearing 5-(aminomethylene) pyrimidine-2,4,6-trione moiety were designed, synthesized, and evaluated for their c-Met kinase inhibitory activities and antiproliferative activities against 5 cancer cell lines (HT-29, H460, MKN-45, A549, and U87MG) in vitro. Most compounds showed moderate to excellent potency, with the most promising analogue 45 (c-Met half-maximal inhibitory concentration [IC50] = 1.15 nM) showing high selectivity versus 5 other tyrosine kinases, VEGFR-2, Flt-3, PDGFR-β, c-Kit, and EGFR. Structure-activity relationship studies indicated that electron-donating groups on the phenyl ring at the 3-position of pyrimidine-2,4,6-trione were required to increase the electron density on the 5-(aminomethylene)pyrimidine-2,4,6-trione moiety.