15720-25-9

Basic information

• Product Name: desthiobiotin
• Synonyms: 4-Imidazolidinehexanoic acid, DL-5-methyl-2-oxo-;Nsc 3085;X 21
• CAS NO: 15720-25-9
• Molecular Formula: C₁₀H₁₈N₂O₃
• Molecular Weight: 214.26152
• EINECS: 208-566-2
• Mol File: 15720-25-9.mol

Chemical Properties

• Boiling Point: 476.4°Cat760mmHg
• Flash Point: 241.9°C
• Appearance: /
• Density: 1.095g/cm³
• Vapor Pressure: 2.18E-10mmHg at 25°C
• Refractive Index: 1.472
• CAS DataBase Reference: desthiobiotin(CAS DataBase Reference)
• NIST Chemistry Reference: desthiobiotin(15720-25-9)
• EPA Substance Registry System: desthiobiotin(15720-25-9)

Safety Data

• Hazardous Substances Data: 15720-25-9(Hazardous Substances Data)

Usage

Uses

6-(5-Methyl-2-oxoimidazolidin-4-yl)hexanoic Acid is a Biotin auxotroph.

InChI:InChI=1/C10H18N2O3/c1-7-8(12-10(15)11-7)5-3-2-4-6-9(13)14/h7-8H,2-6H2,1H3,(H,13,14)(H2,11,12,15)

Upstream product

• 4793-80-0 6-(5-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-hexanoic acid 
• 412308-57-7 7,8-diamino-nonanoic acid ethyl ester 
• 39215-52-6 ethyl 6-(5-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-6-oxohexanoate 
• 82538-68-9 cis methoxy-1 nonene-7 
• 82538-67-8 methoxy-1 nonyne-7 
• 1071-71-2 ethyl 6-chloro-6-oxohexanoate 
• 25542-62-5 6-bromo-hexanoic acid ethyl ester 
• 3054-07-7 2-amino-octanedioic acid 
• 25542-63-6 2-acetyl-octanedioic acid diethyl ester 
• 98-98-6 2-Picolinic acid 
• 82538-66-7 iodo-6 methoxy-1 hexane 
• 22692-46-2 chloro-6 methoxy-1 hexane 
• 2009-83-8 6-chloro-1-hexanol 
• 139936-50-8 (+/-)-9-mercaptothiobiotin dimer 

Downstream Products

• 80750-24-9 NHS-desthiobiotin 

Related news

Development of an enzymatic method for site-specific incorporation of desthiobiotin (cas 15720-25-9) to recombinant proteins in vitro09/06/2019

To extend the (strept)avidin-biotin technology for affinity purification of proteins, development of reusable biochips and immobilized enzyme bioreactors, selective immobilization of a protein of interest from a crude sample to a protein array without protein purification and many other possible...detailed

Easily reversible desthiobiotin (cas 15720-25-9) binding to streptavidin, avidin, and other biotin-binding proteins: uses for protein labeling, detection, and isolation09/04/2019

The high-affinity binding of biotin to avidin, streptavidin, and related proteins has been exploited for decades. However, a disadvantage of the biotin/biotin-binding protein interaction is that it is essentially irreversible under physiological conditions. Desthiobiotin is a biotin analogue tha...detailed

Affinity recovery of lentivirus by diaminopelargonic acid mediated desthiobiotin (cas 15720-25-9) labelling09/03/2019

Desthiobiotin-tagged lentiviral vectors have been metabolically produced by DBL producer cells in a 7,8-diaminopelargonic acid (7-DAPA) dependent manner for envelope independent, single-step affinity purification. 7-DAPA, which has little or no affinity for avidin/streptavidin, was synthesised a...detailed

Relevant articles and documents

Synthesis and Biological Activity of 9-Mercaptodethiobiotin - a Putative Biotin Precursor in Escherichia coli

A total synthesis of (+/-)-9-mercaptodethiobiotin 3 via the aldehyde 9 is described.Compound (+/-)-3 does not function as a biotin replacement factor for an E. coli mutant (SA291) lacking the entire biotin synthesis operon (bioABFCD-) but supports growth of an E. coli bioA mutant.Compound (+/-)-3 also supports growth of transformed cells of SA291 carrying a plasmid encoding the E. coli biotin synthase (bioB) gene indicating that the compound may be able to substitute for dethiobiotin 2 as a substrate for biotin synthase.