157634-01-0

Basic information

• Product Name: 1-benzylpiperidine-2-carbaldehyde
• Synonyms: 1-benzylpiperidine-2-carbaldehyde;2-Piperidinecarboxaldehyde, 1-(phenylmethyl)-
• CAS NO: 157634-01-0
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.28018
• Mol File: 157634-01-0.mol

Chemical Properties

• Boiling Point: 299.5±33.0 °C(Predicted)
• Appearance: /
• Density: 1.114±0.06 g/cm3(Predicted)
• PKA: 7.68±0.10(Predicted)
• CAS DataBase Reference: 1-benzylpiperidine-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzylpiperidine-2-carbaldehyde(157634-01-0)
• EPA Substance Registry System: 1-benzylpiperidine-2-carbaldehyde(157634-01-0)

Safety Data

• Hazardous Substances Data: 157634-01-0(Hazardous Substances Data)

Usage

Chemical Family

Piperidine derivatives

Physical State

Yellowish liquid

Odor

Potent

Usage

Intermediate in the synthesis of various pharmaceuticals and organic compounds

Potential Properties

Psychoactive and analgesic

Applications

Development of new drugs

Chemical Structure

Benzyl group attached to a piperidine ring

Upstream product

• 137650-02-3 (1-benzylpiperidin-2-yl)methanol 
• 98-88-4 benzoyl chloride 
• 4043-87-2 pipecolic Acid 
• 78348-46-6 N-benzoyl-2-piperidinecarboxylic acid 

Downstream Products

• 66120-27-2 1-(N-benzylamino)-2-vinylpiperidine 
• 177665-11-1 9-(benzylamino)-2-methyl-2-methoxynon-4-enoic acid lactam 

Relevant articles and documents

Synthesizing process of nitrogen-heterocyclic high-selectivity aldehyde

The invention relates to a synthesizing process of nitrogen-heterocyclic high-selectivity aldehyde. The synthesizing process is characterized in that when nitrogen-heterocyclic nitrogen atoms have hydrogen atoms, pyrrole, piperidine and pyrazole are used as the initial raw materials, and the pyrrole, the piperidine and the pyrazole are allowed to have reaction with piperidine-1-formaldehyde under nitrogen atom protection to obtain required nitrogen-atom ortho-position aldehyde; when nitrogen-heterocyclic nitrogen atoms have no hydrogen atoms, pyridine and pyrimidine are used to have reaction with the piperidine-1-formaldehyde to obtain the required nitrogen-atom ortho-position aldehyde. The synthesizing process is simple to operate, few in steps and high in selectivity and is a universal method using nitrogen heterocycle to synthesize the nitrogen ortho-position aldehyde.

NHC-Catalyzed intramolecular redox amidation for the synthesis of functionalized lactams

A very efficient NHC-catalyzed lactamization reaction is reported. For most cases, the ring expansion reaction proceeds to cleanly furnish five- and six-membered N-Ts and N-Bn lactams, without the need for further purification. Evidence is presented suggesting a dual role for the stoichiometric base: (1) deprotonation of the triazolium precatalyst and (2) activation of the nitrogen leaving group through hydrogen bonding.

Ring-expansion of tertiary cyclic α-vinylamines by tandem conjugate addition to (p-toluenesulfonyl)ethyne and formal 3-aza-Cope rearrangement

A novel ring-expansion protocol is based on the conjugate additions of cyclic α-vinylamines to (p-toluenesulfonyl)ethyne, followed by aza-Cope rearrangements of the resulting zwitterions, to afford medium and large-ring cyclic amines under remarkably mild

Photochemical reaction between tertiary allylic amines and chromium carbene complexes: Synthesis of lactams via a zwitterion aza cope rearrangement

Photolysis of chromium carbene complexes in the presence of tertiary allylic amines resulted in a zwitterionic aza Cope rearrangement to produce unsaturated lactams in fair yield.