157662-77-6

Basic information

• Product Name: (4-FLUORO-3-NITROPHENYL)ACETONITRILE
• Synonyms: (4-FLUORO-3-NITROPHENYL)ACETONITRILE;2-(4-FLUORO-3-NITROPHENYL)ACETONITRILE
• CAS NO: 157662-77-6
• Molecular Formula: C₈H₅FN₂O₂
• Molecular Weight: 180.14
• Product Categories: Aromatic Nitriles
• Mol File: 157662-77-6.mol

Chemical Properties

• Boiling Point: 349.982°C at 760 mmHg
• Flash Point: 165.464°C
• Appearance: /
• Density: 1.368g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (4-FLUORO-3-NITROPHENYL)ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-FLUORO-3-NITROPHENYL)ACETONITRILE(157662-77-6)
• EPA Substance Registry System: (4-FLUORO-3-NITROPHENYL)ACETONITRILE(157662-77-6)

Safety Data

• Hazardous Substances Data: 157662-77-6(Hazardous Substances Data)

Usage

Application

(4-Fluoro-3-Nitrophenyl)Acetonitrile is a useful research chemical compound.

InChI:InChI=1/C8H5FN2O2/c9-7-2-1-6(3-4-10)5-8(7)11(12)13/h1-2,5H,3H2

Upstream product

• 13435-20-6 tetraethylammoniumcyanide 
• 15017-52-4 4-(bromomethyl)-1-fluoro-2-nitrobenzene 
• 446-11-7 4-fluoro-3-nitrotoluene 
• 42564-51-2 4-fluoro-3-nitrobenzaldehyde 
• 459-57-4 4-fluorobenzaldehyde 
• 773837-37-9 sodium cyanide 
• 20274-70-8 4-(chloromethyl)-1-fluoro-2-nitrobenzene 
• 459-22-3 4-fluorophenylacetonitrile 
• 20274-69-5 (4-fluoro-3-nitrophenyl)methanol 

Downstream Products

• 157662-78-7 2-(4-Fluoro-3-nitro-phenyl)-ethylamine 
• 226888-37-5 4-fluoro-3-nitrophenylacetic acid methyl ester 
• 192508-36-4 2-(4-fluoro-3-nitrophenyl)acetic acid 
• 454186-13-1 2-(4-fluoro-3-nitro-phenyl)-N-methyl-acetamide 
• 454185-89-8 [2-(4-fluoro-3-nitro-phenyl)-ethyl]-methyl-carbamic acid ethyl ester 
• 454186-14-2 3-{4-[(S)-6,7-Dimethoxy-8-(6-methoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl]-phenoxy}-4-isopropoxy-benzoic acid methyl ester 
• 454185-87-6 3-[4-((S)-8-{4-[2-(Ethoxycarbonyl-methyl-amino)-ethyl]-2-methoxy-phenoxy}-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenoxy]-4-isopropoxy-benzoic acid methyl ester 
• 454186-06-2 8-{4-[2-(ethoxycarbonyl-methyl-amino)-ethyl]-2-nitro-phenoxy}-1-[4-(2-isopropoxy-5-methoxycarbonyl-phenoxy)-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 192508-38-6 <2-(4-fluoro-3-nitrophenyl)-acetylamino>-acetic acid 
• 192508-37-5 <2-(4-fluoro-3-nitrophenyl)-acetylamino>-acetic acid methyl ester 
• 192508-41-1 2-(4-fluoro-3-nitrophenyl)-N-<(3-hydroxy-4-methoxy-benzylcarbamoyl)-methyl>acetamide 
• 192508-40-0 2-(4-fluoro-3-nitrophenyl)-N-<(3-isopropoxy-4-methoxy-benzylcarbamoyl)-methyl>acetamide 

Relevant articles and documents

MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE

Provided are IDO inhibitor compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases such as chronic viral infection, chronic bacterial infections, cancer, sepsis or a neurological disorder.

IDO INHIBITORS

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention. Formula (I).

The first examples of S(N)Ar-based macrocyclisation: Synthesis of model carboxylate-binding pockets of vancomycin

Model carboxylate-binding pocket C-O-D rings of vancomycin and related glycopeptides were efficiently synthesized by intramolecular S(N)Ar reaction.

SNAr-Based Macrocyclization: An Application to the Synthesis of Vancomycin Family Models

The first examples of macrocyclization using the intramolecular SNAr reaction are reported.The method has allowed the efficient preparation of the elusive 16-membered macrocyclic COD and DOE rings related to vancomycin.The mild conditions used allow the incorporation of very racemization-prone amino acids, such as p-methoxyphenylglycine, into the peptide chain.After serving as an activator, the nitro group ortho to the diaryl ether linkage is converted either into a chlorine or a hydrogen atom, thus achieving the substitution pattern found in the vancomycin family of glycopeptides.When compound 20 was submitted to the same macrocyclization conditions, two atropisomers 21 and 22 were isolated and characterized.