226888-37-5

Basic information

• Product Name: METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE
• Synonyms: METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE;Methyl (4-fluoro-3-nitrophenyl)acetate
• CAS NO: 226888-37-5
• Molecular Formula: C₉H₈FNO₄
• Molecular Weight: 213.16
• Mol File: 226888-37-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE(226888-37-5)
• EPA Substance Registry System: METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE(226888-37-5)

Safety Data

• Hazardous Substances Data: 226888-37-5(Hazardous Substances Data)

Usage

Description

METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE is an organic compound that belongs to the class of phenylacetates. It is a clear, colorless liquid with a fruity odor. The presence of a nitro group and a fluorine atom in the molecule makes it useful in medicinal chemistry and as a building block in organic synthesis. Its unique chemical structure and properties make it a versatile compound for various industrial applications.

Uses

Used in Pharmaceutical Industry:
METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE is used as an intermediate in the synthesis of various pharmaceuticals for its versatile chemical structure and properties.
Used in Agrochemical Industry:
METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE is used in the synthesis of various agrochemicals, contributing to the development of effective and innovative products for agricultural applications.
Used in Fine Chemicals Production:
METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE is used as an intermediate in the production of fine chemicals, playing a crucial role in creating high-quality specialty products.
Used in Research and Development:
METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE is utilized in research and development settings to explore its potential applications and enhance the understanding of its chemical properties and behavior in various reactions.

Upstream product

• 67-56-1 methanol 
• 949570-83-6 C₈H₄FN₃O₃ 
• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 
• 405-50-5 p-Fluorophenylacetic acid 
• 192508-36-4 2-(4-fluoro-3-nitrophenyl)acetic acid 
• 400-94-2 4-fluoro-3-nitrobenzoyl chloride 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 157662-77-6 2-(4-fluoro-3-nitrophenyl)acetonitrile 

Downstream Products

• 949570-69-8 methyl 4-chloro-2-(4-(2-methoxy-2-oxoethyl)-2-nitrophenoxy)benzoate 
• 1455471-80-3 ethyl 2-((4-(2-methoxy-2-oxoethyl)-2-nitrophenyl)thio)acetate 
• 1455471-87-0 methyl 2-((4-(2-methoxy-2-oxoethyl)-2-nitrophenyl)amino)acetate 
• 257632-77-2 methyl (3-amino-4-fluorophenyl)acetate 
• 226888-23-9 2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-isopropoxy-4-methoxybenzyl)-3-phenylpropionamide 
• 226888-40-0 2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-hydroxy-4-methoxybenzyl)-3-phenylpropionamide 
• 192508-40-0 2-(4-fluoro-3-nitrophenyl)-N-<(3-isopropoxy-4-methoxy-benzylcarbamoyl)-methyl>acetamide 
• 192508-41-1 2-(4-fluoro-3-nitrophenyl)-N-<(3-hydroxy-4-methoxy-benzylcarbamoyl)-methyl>acetamide 
• 192508-37-5 <2-(4-fluoro-3-nitrophenyl)-acetylamino>-acetic acid methyl ester 
• 192508-38-6 <2-(4-fluoro-3-nitrophenyl)-acetylamino>-acetic acid 
• 192508-36-4 2-(4-fluoro-3-nitrophenyl)acetic acid 

Relevant articles and documents

Preparation method of 3-nitro-4-fluorophenylacetate

The invention discloses a method for preparing 3-nitro-4-fluorophenylacetate by using a microreactor, and belongs to the technical field of organic matter synthesis, the microreactor comprises precooling modules and a mixing module, and the method specifically comprises the following steps: (1) preparing raw materials: preparing a mixed solution of 4-fluorophenylacetate and concentrated sulfuric acid and a nitric acid solution; (2) pre-cooling: cooling the pre-cooling modules and the mixing module to a reaction temperature in advance, and then respectively adding the mixed solution of 4-fluorophenylacetate and concentrated sulfuric acid and the nitric acid solution into different pre-cooling modules; (3) mixing: after the raw materials are pre-cooled, adding the pre-cooled raw materials into the mixing module for mixing reaction; and (4) performing quenching and post-processing. The method provided by the invention can effectively control the heat release problem of the nitration reaction, and is high in safety; and the 3-nitro-4-fluorophenylacetate can be prepared with high selectivity, the conversion rate of the 4-fluorophenylacetate can reach 98.4%, and the selectivity can reach99: 1.

SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS

The present invention relates to a series of substituted compounds having the general formula (I), including their ste reoisomers and/or their pharmaceutically acceptable salts, wherein R1, R2, R3. R4, R5, and R6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

NOVEL BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS

The present invention relates to novel benzimidazole derivatives of the formula (I) as defined in the description and in the claims, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for inducing and maintaining anaesthesia, sedation and muscle relaxation, as well as for combating febrile convulsions in children. The compounds of the invention may also be used by veterinarians.