192508-40-0

Upstream product

• 192508-38-6 <2-(4-fluoro-3-nitrophenyl)-acetylamino>-acetic acid 
• 226888-21-7 3-isopropoxy-4-methoxybenzonitrile 
• 192508-36-4 2-(4-fluoro-3-nitrophenyl)acetic acid 
• 226888-37-5 4-fluoro-3-nitrophenylacetic acid methyl ester 
• 192508-37-5 <2-(4-fluoro-3-nitrophenyl)-acetylamino>-acetic acid methyl ester 
• 157662-77-6 2-(4-fluoro-3-nitrophenyl)acetonitrile 
• 34123-66-5 O-isopropylisovanillin 
• 621-59-0 isovanillin 

Downstream Products

• 192508-41-1 2-(4-fluoro-3-nitrophenyl)-N-<(3-hydroxy-4-methoxy-benzylcarbamoyl)-methyl>acetamide 

Relevant academic research and scientific papers

Synthetic studies towards western and eastern macropolypeptide subunits of Kistamycin

The western subunit (fused bicyclic 16+15 membered ring) was synthesized by sequential intramolecular S(N)Ar reaction and the first 17-membered ring compound as model of the eastern subunit was obtained by an intramolecular Ni0 mediated coupling reaction.

The first synthesis of a 15-membered macrocycle. Model of ring I of kistamycin

The intramolecular S(N)Ar reaction of a linear peptide precursor, whose termini carry respectively an ortho fluoro-nitro group and a phenol function, gives the 15-membered ring compound in good yield, under mild conditions.