158251-56-0

Basic information

• Product Name: flutazolam
• Synonyms: Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one, 10-chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)-, (S)-
• CAS NO: 158251-56-0
• Molecular Formula: C19H18 Cl F N2 O3
• Molecular Weight: 376.81
• Mol File: 158251-56-0.mol

Chemical Properties

• Boiling Point: 601.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.47±0.1 g/cm3(Predicted)
• PKA: 14.49±0.10(Predicted)
• CAS DataBase Reference: flutazolam(CAS DataBase Reference)
• NIST Chemistry Reference: flutazolam(158251-56-0)
• EPA Substance Registry System: flutazolam(158251-56-0)

Safety Data

• Hazardous Substances Data: 158251-56-0(Hazardous Substances Data)

Upstream product

• 102408-32-2 7-Chloro-5-(2-fluoro-phenyl)-1,4-bis-(2-hydroxy-ethyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4-ium 
• 101489-22-9 N-[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-N-(2-hydroxy-ethyl)-2-(2-hydroxy-ethylamino)-acetamide 
• 24143-22-4 10-chloro-11b-(2-fluoro-phenyl)-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one 
• 540-51-2 2-bromoethanol 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 102408-32-2 7-Chloro-5-(2-fluoro-phenyl)-1,4-bis-(2-hydroxy-ethyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4-ium 

Relevant articles and documents

Intermediates for tricyclic benzodiazepines

Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.