- Synthesis of 5- tert-butyl-8, 12, 14-trimethyl- and 5- tertbutyl- 8, 12, 14, 16-tetramethyI[2.2]metacyclophane and their treatment with lewis acids in benzene
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Treatment of 5-tert-butyl-8,12,14,16-tetramethyl[2.2]MCP with AICI 3-MeN02 in benzene led to trans-tert-butylation to afford 8,12,14,16-tetramethyl[2.2]MCP in good yield along with tert-butylbenzene. On the other hand, the same treat
- Shimizu, Tomoe,Hida, Katsuhiko,Yamato, Takehiko
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Read Online
- Conformational control of bis-urea self-assembled supramolecular pH switchable low-molecular-weight hydrogelators
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We report the synthesis and investigation into the structure-property relationships of eight different low molecular weight hydrogelators based on a bisaromatic urea core unit, all of which form gels as the pH of the solution is lowered. The low molecular weight hydrogelators are functionalized with carboxylic acid moieties on one aromatic ring, and the other aromatic ring features a nitro functional group either in the meta- or paraposition relative to the urea linkage. Ortho-methyl substituents were installed on the aromatic rings to enforce a non-coplanar arrangement between the phenyl and urea moieties. Gel formation was triggered by the addition of a mineral acid or the ring-opening hydrolysis of glucono-δ-lactone. The low molecular weight hydrogelators were studied by a variety of analytical techniques, including NMR spectroscopy and rheology. In addition, their ability to uptake a dye, methylene blue, was determined by UV-vis spectroscopy. (Figure Presented)
- Chippindale, Ann M.,Christie, William,Gavriel, Alexander G.,German, Ian M.,Hayes, Wayne,O'Donnell, Adam D.
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- Modulation of the coordination geometries of NCN and NCNC Rh complexes for ambidextrous chiral catalysts
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A chirality switch between novel NCN pincer Rh complexes and a related double cyclometalated NCNC Rh complex containing secondary amino groups is described. Their catalytic abilities were determined in asymmetric alkynylation of ethyl trifluoropyruvate, a
- Ito, Jun-Ichi,Ishihara, Takahiro,Fukuoka, Takaki,Binti Mat Napi, Siti Rokiah,Kameo, Hajime,Nishiyama, Hisao
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supporting information
p. 12765 - 12768
(2019/11/05)
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- Synthesis and biological evaluation of dihydropyrano-[2,3-c]pyrazoles as a new class of PPAR? partial agonists
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Peroxisome proliferator-activated receptor ? (PPAR?) is a well-known target for thiazolidinedione antidiabetic drugs. In this paper, we present the synthesis and biological evaluation of a series of dihydropyrano[2,3-c]pyrazole derivatives as a novel family of PPAR? partial agonists. Two analogues were found to display high affinity for PPAR? with potencies in the micro molar range. Both of these hits were selective against PPAR?, since no activity was measured when tested against PPARα, PPAR? and RXRα. In addition, a novel modelling approach based on multiple individual flexible alignments was developed for the identification of ligand binding interactions in PPAR?. In combination with cell-based transactivation experiments, the flexible alignment model provides an excellent analytical tool to evaluate and visualize the effect of ligand chemical structure with respect to receptor binding mode and biological activity.
- Qvortrup, Katrine,Jensen, Jakob F.,S?rensen, Mikael S.,Kouskoumvekaki, Irene,Petersen, Rasmus K.,Taboureau, Olivier,Kristiansen, Karsten,Nielsen, Thomas E.
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- Two birds with one stone: Self-assembly of metal-organic coordination complexes with discrete metallamacrocycle and 1D zigzag chain based on a flexible dicarboxylate ligand
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To assemble metal-organic coordination complexes, a flexible dicarboxylate ligand, 2,2′-(4,6-dimethyl-5-nitro-1,3-phenylene)bis(methylene)-bis- (sulfanediyl)dibenzoic acid (H2L), has been designed and synthesized. Using the flexible ligand to a
- Guo, Jie,Zhang, Liangliang,Ma, Huiqing,Chen, Zhen,Sun, Di,Wei, Yanhui,Sun, Daofeng
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- An experimental and theoretical study on imidazolium-based ionic liquid promoted chloromethylation of aromatic hydrocarbons
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The chloromethylation of aromatic hydrocarbons proceeded efficiently using the reusable imidazolium-based ionic liquid as promoter. Mild reaction conditions, enhanced rates, improved yields, recyclability of ionic liquids, and reagents' reactivity which is different from that in conventional organic solvents are the remarkable features observed in ionic liquids. The ionic liquids were recycled in three subsequent runs with no decrease in activity. In addition, the results of calculations with the Gaussian 98 suite of program are in good accordance with the experimental outcomes.
- Wang, Yun,Xi, Yanli
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p. 2196 - 2199
(2014/03/21)
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- Efficient dichloromethylation of some aromatic hydrocarbons catalyzed by a new ionic liquid [C12minPEG800]br under homogeneous catalysis in aqueous media
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A series of new imidazolium-type ionic liquids based on polyethylene glycol have been prepared. The new recyclable temperature-dependant phase-separation system comprised of [C12minPEG800]Br and methylcyclohexane was also developed and successfully applied to the dichloromethylation of some aromatic hydrocarbons to prepare dichloromethyl-substituted hydrocarbons in excellent yields. The ionic liquid could be excellent recycled without any apparent loss of catalytic activity and little loss of weight even after 8 times recycling.
- Hu,Liu,Lu,Lu,Ge,Zhang
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experimental part
p. 131 - 141
(2012/01/03)
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- Inclusion of an anion guest within a molecular host formed by (4,6-dimethyl-1,3-phenylene)bis( N , N-dibenzylmethane) and [CuCl 4]2-/[TeCl6]2- through second-sphere coordination
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In this work, we have utilized the second-sphere coordination approach toward the construction of supramolecular inclusion solids Cl 2H2O [H2L1]0.5 [CuCl4]0.5 (Crystal 1) and Cl [H2/s
- Guo, Fang,Zhang, Shuang,Guan, Hong-Yu,Lu, Na,Guo, Wen-Sheng
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experimental part
p. 2223 - 2233
(2012/07/13)
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- An inexpensive and efficient synthetic method for the preparation of pyromellitic dianhydride promoted by ionic liquid
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In this article, pyromellitic dianhydride could be successfully obtained in 76.7% total yield by an aerobic oxidation of 1,4-bis(chloromethyl)-2,5- dimethylbenzene or 1,5-bis(chloromethyl)-2,4- dimethylbenzene catalyzed by VO(acac)2/Cu(2-Eth)2/DABCO in [hmim]OTf and a subsequent dehydration of pyromellitic acid upon heating with acetic anhydride. The starting materials including 1,2-bis(chloromethyl)-4,5-dimethylbenzene were prepared by dichloromethylation of their corresponding xylene catalyzed by [C12mim]Br in aqueous media. ARKAT USA, Inc.
- Hu, Yu Lin,Lu, Ming,Liu, Xiao Bin,Zhang, Sheng Bin,Ji, Zhan Hui,Lu, Ting Ting
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experimental part
p. 63 - 74
(2010/10/19)
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- Identification of alkylarene chloromethylation products using gas-chromatographic retention indices
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Gas-chromatographic retention indices on standard nonpolar polydimethylsiloxane stationary phases allow identification of products formed by known organic reactions even without using mass-spectrometric data. The efficiency of this approach was demonstrated by the example of identification of previously uncharacterized chloromethyl derivatives of alkylarenes, including structural isomers of compounds containing several chloromethyl groups, directly in reaction mixtures. Chromatographic analysis of such reaction mixtures allows identification of positional isomers of the starting alkylarenes even when they are present simultaneously. The retention indices were determined for the first time for more than 50 alkyl-(chloromethyl)arenes, by-products of chloromethylation, and chloromethyl derivatives of the simplest alkyl phenyl ketones. Nauka/Interperiodica 2007.
- Zenkevich,Makarov
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p. 611 - 619
(2008/03/18)
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- [emim]BF4-promoted chloromethylation of aromatic hydrocarbons
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The chloromethylation of aromatic hydrocarbons proceeded efficiently using the reusable ionic liquid [emim]BF4 as promoter. The reactions were completed in 5 h at 70°C with good yields and easy workup. Copyright Taylor & Francis Group, LLC.
- Wang, Yun,Shang, Zhi-Cai,Wu, Tian-Xing
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p. 3053 - 3059
(2007/10/03)
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- COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF
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The present invention provides novel beta-secretase inhibitors of the general formula (I), where the variables A1, A2, L1, L2, L3, R1, R2, R3, R4, R5, R6 and R7 are as defined in the claims, a method for their use in treating Alzheimer's disease, and methods for their use in reducing memapsin 2 catalytic activity.
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Page/Page column 61
(2008/06/13)
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