159183-89-8

Basic information

• Product Name: 2-Acetylamino-5-hydroxypyridine
• Synonyms: 2-Acetylamino-5-hydroxypyridine;N-(5-Hydroxypyridin-2-yl)acetaMide;Acetamide,N-(5-hydroxy-2-pyridinyl)-
• CAS NO: 159183-89-8
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.15
• Product Categories: pharmacetical
• Mol File: 159183-89-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-Acetylamino-5-hydroxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetylamino-5-hydroxypyridine(159183-89-8)
• EPA Substance Registry System: 2-Acetylamino-5-hydroxypyridine(159183-89-8)

Safety Data

• Hazardous Substances Data: 159183-89-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-Acetylamino-5-hydroxypyridine is utilized as a key intermediate in the synthesis of certain pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Acetylamino-5-hydroxypyridine serves as a valuable building block for the creation of complex organic molecules, facilitating the advancement of chemical research and innovation.
Used in Medical Treatment:
2-Acetylamino-5-hydroxypyridine is being studied for its potential use in the treatment of various medical conditions, leveraging its mild antibacterial and anti-inflammatory properties to provide therapeutic benefits.
Used in Antibacterial Applications:
Due to its mild antibacterial properties, 2-Acetylamino-5-hydroxypyridine is considered for use in applications that require the inhibition of bacterial growth, contributing to the development of new antimicrobial agents.
Used in Anti-inflammatory Applications:
2-Acetylamino-5-hydroxypyridine's anti-inflammatory properties make it a candidate for use in treatments aimed at reducing inflammation, offering potential benefits in managing inflammatory conditions.

Upstream product

• 109-00-2 3-HYDROXYPYRIDINE 
• 35771-41-6 6-[2-(4-nitrophenyl)diazenyl]-3-pyridinol 
• 856965-37-2 2-amino-5-hydroxypyridine hydrochloride 
• 75-36-5 acetyl chloride 
• 1204413-49-9 2-acetamido-5-benzyloxypyridine 
• 76066-09-6 N-(5-methoxy-2-pyridyl)acetamide 

Relevant articles and documents

Inhibition of colitis by ring-modified analogues of 6-acetamido-2,4,5-trimethylpyridin-3-ol

6-Aminopyridin-3-ol scaffold has shown an excellent anti-inflammatory bowel disease activity. Various analogues with the scaffold were synthesized in pursuit of the diversity of side chains tethering on the C(6)-position. Structure-activity relationship among the analogues was investigated to understand the effects of the side chains and their linkers on their anti-inflammatory activities. In this study, structural modification moved beyond side chains on the C(6)-position and reached to pyridine ring itself. It expedited us to synthesize diverse ring-modified analogues of a representative pyridine-3-ol, 6-acetamido-2,4,5-trimethylpyridin-3-ol (9). In the evaluation of compounds on their inhibitory actions against TNF-α-induced adhesion of monocytic cells to colonic epithelial cells, an in vitro model mimicking colon inflammation, the effects of compounds 9, 17, and 19 were greater than tofacitinib, an orally available anti-colitis drug, and compound 17 showed the greatest activity. In addition, TNF-α-induced angiogenesis, which permits more inflammatory cell migration into inflamed tissues, was significantly blocked by compounds 17 and 19 in a concentration-dependent manner. In the comparison of in vivo therapeutic effects of compounds 9, 17, and 19 on dextran sulfate sodium (DSS)-induced colitis in mice, compound 17 was the most potent and efficacious, and compound 19 was better than compound 9 which showed a similar degree of inhibitory effect to tofacitinib. Taken together, it seems that either the trimethyl system or the hydroxyl group on the pyridinol ring is essential to the activity. This finding might become a new milestone in the development of pyridinol-based anti-inflammatory bowel disease agents.

Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis

Herein we report an investigation of the efficacy of pyridine and pyrimidine analogs of acetaminophen (ApAP) as peroxyl radical-trapping antioxidants and inhibitors of enzyme-catalyzed lipid peroxidation by cyclooxygenases (COX) and lipoxygenases (LOX). I

Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity

Substituted phenylsulfonamides are selective β 3 adrenergic receptor agonists with very little β 1 and β 2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduced neurogenic inflammation or as antidepressant agents. The compounds are prepared by coupling an aminoalkylphenyl-sulfonamide with an appropriately substituted alkyl epoxide. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility are also disclosed.