159503-76-1

Basic information

• Product Name: 1H-Indole-3-MethanaMine, 7-chloro-N,N-diMethyl-
• Synonyms: 1H-Indole-3-MethanaMine, 7-chloro-N,N-diMethyl-
• CAS NO: 159503-76-1
• Molecular Formula: C11H13ClN2
• Molecular Weight: 208.68732
• Mol File: 159503-76-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole-3-MethanaMine, 7-chloro-N,N-diMethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-MethanaMine, 7-chloro-N,N-diMethyl-(159503-76-1)
• EPA Substance Registry System: 1H-Indole-3-MethanaMine, 7-chloro-N,N-diMethyl-(159503-76-1)

Safety Data

• Hazardous Substances Data: 159503-76-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indole-3-methanamine, 7-chloro-N,N-dimethylis used as a research compound for exploring its potential therapeutic applications in the treatment of various central nervous system disorders. Its effects on mood, appetite, and sleep regulation make it a promising candidate for conditions such as migraine headaches and depression.
Used in Drug Discovery and Development:
1H-Indole-3-methanamine, 7-chloro-N,N-dimethylis utilized as a starting material or a structural template in the development of new drugs targeting the central nervous system. Its unique chemical properties and interactions with serotonin receptors offer opportunities for the design of novel therapeutic agents with improved efficacy and safety profiles.

Upstream product

• 53924-05-3 7-chloro-1H-indole 
• 124-40-3 dimethyl amine 
• 50-00-0 formaldehyd 
• 30354-18-8 N,N-dimethyl(methylene)ammonium chloride 

Downstream Products

• 221377-34-0 3-(7-chloro-1H-indol-3-yl)-4-<7-chloro-1-<4-O-methyl-3,6-bis-O-(phenymethyl)-β-D-glucopyranosyl>-1H-indol-3-yl>-1H-pyrrole-2,5-dione 
• 221377-35-1 3-(1H-indol-3-yl)-4-<7-chloro-1-<4-O-methyl-3,6-bis-O-(phenymethyl)-β-D-glucopyranosyl>-1H-indol-3-yl>-1H-pyrrole-2,5-dione 
• 221377-36-2 7-chloro-1-<4-O-methyl-3,6-bis-O-(phenymethyl)-β-D-glucopyranosyl>-1H-indole-3-acetamide 
• 153-97-9 7-chloro-D/L-tryptophan 
• 870481-87-1 2-tert-butoxycarbonylamino-3-(7-chloro-1H-indol-3-yl)-propionic acid 
• 221377-37-3 7-chloro-1H-indole-3-acetonitrile 

Relevant articles and documents

COMPOUNDS, SCREENS, AND METHODS OF TREATMENT

The present invention features compounds, pharmaceutical compositions, and methods for treating trauma, ischemia, stroke, degenerative diseases associated with cellular necrosis, and other conditions. Screening assays for identifying compounds useful for treating these conditions are also described.

Inhibitors of cellular necrosis

The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly useful for treating neurological disorders associated with cellular necrosis.

Structure-activity relationship study of novel necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.

Synthesis of rebeccamycin and 11-dechlororebeccamycin

Glycosylated 7-chloroindole-3-acetamide 9, prepared in four steps and 26% yield from 7-chloroindole (1), was condensed with methyl 7-chloroindole- 3-glyoxylate 11 and methyl indole-3-glyoxylate 12 to provide bisindolylmaleimides 7 and 8 in 86% and 84% yield, respectively. Oxidation of 7 and 8 followed by debenzylation provided a new approach to the synthesis of rebeccamycin and completed for the first time a synthesis of 11- dechlororebeccamycin.

INDOLE DERIVATIVES AS DOPAMINE D4 ANTAGONISTS

Compounds of formula (I), or a salt or prodrug thereof, wherein R represent hydrogen or C 1-6 alkyl; Q represents a moiety of formula Qa or Qb; they are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopami