159572-93-7

Basic information

• Product Name: 2-Piperazinecarboxamide,(2S)-(9CI)
• Synonyms: 2-Piperazinecarboxamide,(2S)-(9CI);2-PiperazinecarboxaMide, (2S)-;(S)-Piperazine-2-carboxaMide
• CAS NO: 159572-93-7
• Molecular Formula: C5H11N3O
• Molecular Weight: 129.16
• Product Categories: PIPERAZINE
• Mol File: 159572-93-7.mol

Chemical Properties

• Boiling Point: 364.2±37.0 °C(Predicted)
• Appearance: /
• Density: 1.104±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 16.52±0.20(Predicted)
• CAS DataBase Reference: 2-Piperazinecarboxamide,(2S)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperazinecarboxamide,(2S)-(9CI)(159572-93-7)
• EPA Substance Registry System: 2-Piperazinecarboxamide,(2S)-(9CI)(159572-93-7)

Safety Data

• Hazardous Substances Data: 159572-93-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Piperazinecarboxamide, (2S)-(9CI) is used as a chemical intermediate for the synthesis of various drugs and pharmaceutical compounds. Its unique structure and properties make it a valuable building block in the development of new medications.
Used in Pharmaceutical Research:
2-Piperazinecarboxamide, (2S)-(9CI) is used as a research compound to explore its biological activity and potential therapeutic applications. Its unique structure and properties may contribute to the discovery of new drugs and treatments for various diseases and conditions.

Upstream product

• 112257-24-6 tert-butyl 3-(aminocarbonyl)piperazine-1-carboxylate 

Downstream Products

• 1418733-44-4 C₂₀H₃₂N₄O₄ 
• 166520-14-5 3S-(-)-1,1-dimethylethyl 3-aminocarbonyl-4-<<<(4-nitro-2,6-dichlorophenyl)amino>carbonyl>methyl>-1-piperazinecarboxylate 
• 166520-13-4 3R-(+)-1,1-dimethylethyl 3-aminocarbonyl-4-<<<(4-nitro-2,6-dichlorophenyl)amino>carbonyl>methyl>-1-piperazinecarboxylate 
• 166520-16-7 2S-(-)-1,1-dimethylethyl 3-aminocarbonyl-4-<<<(4-amino-2,6-dichlorophenyl)amino>carbonyl>methyl>-1-piperazinecarboxylate 
• 170164-47-3 3S-(+)-1,1-dimethylethyl 3-aminocarbonyl-1-piperazinecarboxylate 
• 170164-46-2 3R-(-)-1,1-dimethylethyl 3-aminocarbonyl-1-piperazinecarboxylate 

Relevant articles and documents

Kinetic resolution of piperazine-2-carboxamide by leucine aminopeptidase. An application in the synthesis of the nucleoside transport blocker (-)draflazine

The resolution of N-t-Boc-piperazine carboxamide 5 proceeded smoothly in the presence of leucine aminopeptidase to produce acid (S)-1 and amide (R)-5 with good optical purity. Sequential alkylation and functional group manipulation of carboxamide (S)-5 provided the known nucleoside transport blocker (-)draflazine 2.

Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles

A series of 1-piperazinyl-N-phenylacetamide derivatives of 4,5-diphenyl-oxazoles, thiazoles, and imidazoles which are novel adenosine transport inhibitors have been found to provide effective antiischemic protection for CNS and cardiac tissue, particularly neurons. A method of treatment to protect against CNS ischemia, such as that resulting from trauma, stroke, or other ischemic conditions, comprises administration of these novel compounds to an individual in need of such treatment.