1596-67-4

Basic information

• Product Name: L-THYRONINE
• Synonyms: S-THYRONINE;O-4-HYDROXYPHENYL-L-TYROSINE;TYROSINE(4-HYDROXYPHENYL)-OH;ALPHA-AMINO-BETA-(4-HYDROXYPHENOXYPHENYL) PROPIONIC ACID;3-[P-(P-HYDROXYPHENOXY)PHENYL]-L-ALANINE;L-THYRONINE;H-BETA-[4-(4-HYDROXYPHENOXY)-PHENYL]-ALA-OH;H-4-(4-HYDROXYPHENOXY)-PHE-OH
• CAS NO: 1596-67-4
• Molecular Formula: C₁₅H₁₅NO₄
• Molecular Weight: 273.28
• EINECS: 216-483-8
• Product Categories: Amino Acids
• Mol File: 1596-67-4.mol

Chemical Properties

• Melting Point: 259-260℃
• Boiling Point: 477.694 °C at 760 mmHg
• Flash Point: 242.701 °C
• Appearance: /
• Density: 1.324 g/cm³
• Storage Temp.: -15°C
• Solubility: Aqueous Base (Slightly), DMSO (Slightly)
• PKA: 2.23±0.10(Predicted)
• CAS DataBase Reference: L-THYRONINE(CAS DataBase Reference)
• NIST Chemistry Reference: L-THYRONINE(1596-67-4)
• EPA Substance Registry System: L-THYRONINE(1596-67-4)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 1596-67-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
L-Thyronine is used as a medication for treating hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormones. It helps in regulating the body's metabolism and ensuring proper growth and development.
Used in Veterinary Medicine:
In the veterinary field, L-Thyronine is used to treat thyroid-related disorders in animals, such as hypothyroidism and goiter. It helps in maintaining the overall health and well-being of the animals by regulating their metabolic processes.
Used in Research and Development:
L-Thyronine is also used in research and development for studying the effects of thyroid hormones on various biological processes, including growth, development, and metabolism. This helps in understanding the underlying mechanisms of thyroid hormone action and developing new therapeutic strategies for related disorders.
Used in Nutritional Supplements:
L-Thyronine is sometimes used as an ingredient in nutritional supplements, particularly for individuals with thyroid-related issues or those looking to support their overall metabolic health. However, it is essential to consult a healthcare professional before using such supplements, as improper use can lead to adverse effects.

InChI:InChI=1/C15H15NO4/c16-14(15(18)19)9-10-1-5-12(6-2-10)20-13-7-3-11(17)4-8-13/h1-8,14,17H,9,16H2,(H,18,19)

Upstream product

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• 904809-03-6 O-(2.6-diiodo-4-nitro-phenyl)-N-benzoyl-L-tyrosine 
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• 1034-10-2 DL-thyronine 
• 51-48-9 L-thyroxine 
• 70-40-6 L-3,3'-Diiodothyronine 
• 5817-39-0 L-3,3',5'-triiodothyronine 
• 6893-02-3 triiodothyronine 

Relevant articles and documents

Remarkable Effect of Chalcogen Substitution on an Enzyme Mimetic for Deiodination of Thyroid Hormones

Iodothyronine deiodinases are selenoenzymes which regulate the thyroid hormone homeostasis by catalyzing the regioselective deiodination of thyroxine (T4). Synthetic deiodinase mimetics are important not only to understand the mechanism of enzyme catalysis, but also to develop therapeutic agents as abnormal thyroid hormone levels have implications in different diseases, such as hypoxia, myocardial infarction, critical illness, neuronal ischemia, tissue injury, and cancer. Described herein is that the replacement of sulfur/selenium atoms in a series of deiodinase mimetics by tellurium remarkably alters the reactivity as well as regioselectivity toward T4. The tellurium compounds reported in this paper represent the first examples of deiodinase mimetics which mediate sequential deiodination of T4 to produce all the hormone derivatives including T0 under physiologically relevant conditions.