Welcome to LookChem.com Sign In|Join Free
  • or

51-48-9

Post Buying Request

51-48-9 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
L-Thyroxine Manufacturer/High quality/Best price/In stock
Cas No: 51-48-9
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High purity Various Specifications L-Thyroxine CAS:51-48-9
Cas No: 51-48-9
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
L-thyroxine CAS:51-48-9 Safe delivery Free of customs clearance
Cas No: 51-48-9
USD $ 1.0-10.0 / Kilogram 1 Kilogram 5000 Kilogram/Month WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
T4 Levothyroxine CAS#51-48-9
Cas No: 51-48-9
USD $ 2.0-3.0 / Kilogram 1 Kilogram 50 Metric Ton/Month ORCHID CHEMICAL SUPPLIES LTD Contact Supplier
Biological research,51-48-9, 99% good L-Thyroxine/API
Cas No: 51-48-9
USD $ 3200.0-3200.0 / Kilogram 1 Kilogram 5000 Kilogram/Month Kono Chem Co.,Ltd Contact Supplier
Factory supply high quality L-Thyroxine Cas 51-48-9 with favorable price
Cas No: 51-48-9
USD $ 3.0-5.0 / Gram 100 Gram 120 Kilogram/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
L-Thyroxine
Cas No: 51-48-9
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
L-Thyroxine
Cas No: 51-48-9
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Factory Supply L-Thyroxine
Cas No: 51-48-9
No Data 100 Gram 400 Metric Ton/Day Ality Chemical Corporation Contact Supplier
L-Thyroxine, 97+%
Cas No: 51-48-9
No Data 1 Metric Ton 10 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier

51-48-9 Usage

Uses

antihypercholesterimic, thyromimetic

Chemical Properties

Crystalline Solid

Purification Methods

Purification is the same as for the D-isomer above. Likely impurities are tyrosine, iodotyrosine, iodothyroxines and iodide. Dissolve it in dilute ammonia at room temperature, then crystallise it by adding di[] 546 +27.8o (c 5, EtOH). [Harrington et al. Biochem J 39 164 1945, Nahm & Siedel Chem Ber 96 1 1963, Reineke & Turner J Biol Chem 161 613 1945, Chalmers et al. J Chem Soc 3424 1949, Beilstein 14 II 378, 14 III 1566, 14 IV 2373.]

Definition

ChEBI: The L-enantiomer of thyroxine.

Brand name

Levo-T (Alara); Levolet (Vintage); Levothroid (Lloyd); Levoxyl (Jones); Novothyrox (Genpharm); Synthroid (Abbott); Unithroid (Stevens J).

Uses

One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroi d hormone, but has been used to treat hyperlipidemia.
InChI:InChI=1/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

51-48-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name L-thyroxine

1.2 Other means of identification

Product number -
Other names L-Thyroxine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:51-48-9 SDS

51-48-9Synthetic route

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With sodium hypochlorite; tert-butylamine; sodium iodide In methanol at 20 - 30℃; Reagent/catalyst; Solvent;100%
With iodine; methylamine; potassium iodide In water at 0 - 5℃; for 2h;95%
With iodine; potassium iodide; sodium hydroxide In water at -10 - 10℃; Reagent/catalyst; Temperature;76.7%
With water; iodine; ethylamine; potassium iodide
With ammonia; iodine; potassium iodide
L-thyroxine, sodium salt hexahydrate

L-thyroxine, sodium salt hexahydrate

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With hydrogenchloride In methanol; dimethyl sulfoxide96%
3,5-diiodo-l-tyrosine
300-39-0

3,5-diiodo-l-tyrosine

5,7-diiodo-1-oxaspiro[2.5]octa-4,7-dien-6-one

5,7-diiodo-1-oxaspiro[2.5]octa-4,7-dien-6-one

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 24℃; for 16h; 0.2 M borate buffer, pH 8.0 (add. of 0.1 M NaOH);94%
3,3′-diiodothyronine
70-40-6

3,3′-diiodothyronine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Stage #1: 3,3′-diiodothyronine With methylamine In methanol at 25 - 30℃;
Stage #2: With iodine In methanol at -8 - 0℃;
Stage #3: With potassium dihydrogenphosphate; sodium hydrogensulfite In methanol at 15 - 20℃;
91.2%
3,5-diiodo-l-tyrosine
300-39-0

3,5-diiodo-l-tyrosine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With sodium hydroxide; dihydrogen peroxide; butan-1-ol
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 1 h
1.2: 2 h / 20 - 40 °C
2.1: diisopropylamine / water; butan-1-ol / 2 h / 20 - 90 °C
2.2: 2 h / 20 - 30 °C
3.1: acetic acid; hydrogen iodide / 5 h / 100 °C
4.1: methylamine / methanol / 25 - 30 °C
4.2: -8 - 0 °C
4.3: 15 - 20 °C
View Scheme
N-acetyl-3,5-diiodo-L-tyrosine
1027-28-7

N-acetyl-3,5-diiodo-L-tyrosine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With air; water at 37℃; Erhitzen des Reaktionsprodukts mit wss. Salzsaeure und Essigsaeure;
3,5-diiodo-l-tyrosine
300-39-0

3,5-diiodo-l-tyrosine

((7R,8S)-8-Hydroxy-5,7-diiodo-6-oxo-1-oxa-spiro[2.5]oct-4-en-2-yl)-oxo-acetic acid

((7R,8S)-8-Hydroxy-5,7-diiodo-6-oxo-1-oxa-spiro[2.5]oct-4-en-2-yl)-oxo-acetic acid

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
at 0℃; for 0.75h; Yield given;
iodoacetamide
27059-94-5

iodoacetamide

3,5-diiodo-thyronine

3,5-diiodo-thyronine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With methanol; triethylamine
1-methyl-4-nitrosobenzene
623-11-0

1-methyl-4-nitrosobenzene

3,5-diiodo-l-tyrosine
300-39-0

3,5-diiodo-l-tyrosine

dihydrogen peroxide
7722-84-1

dihydrogen peroxide

butan-1-ol
71-36-3

butan-1-ol

L-thyroxine
51-48-9

L-thyroxine

casein

casein

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Jodierung und anschliessende Hydrolyse;
4-Hydroxymethyl-2,6-diiodo-cyclohexa-2,5-dienone

4-Hydroxymethyl-2,6-diiodo-cyclohexa-2,5-dienone

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 37 percent / NaBiO3 / ethyl acetate; acetic acid; H2O / 4 h
2: 94 percent / dimethylformamide / 16 h / 24 °C / 0.2 M borate buffer, pH 8.0 (add. of 0.1 M NaOH)
View Scheme
3,5-diiodo-DL-thyronine
534-51-0

3,5-diiodo-DL-thyronine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
2: (-)-α-phenethylamine; water
3: hydrobromic acid
4: concentrated ammonia; potassium iodide; iodine
View Scheme
3.5-diiodo-N.O-diacetyl-L-tyrosine
96679-34-4

3.5-diiodo-N.O-diacetyl-L-tyrosine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. NaOH solution
2: water; air / 37 °C / Erhitzen des Reaktionsprodukts mit wss. Salzsaeure und Essigsaeure
View Scheme
N-formyl-3,5-diiodo-DL-thyronine
94298-44-9

N-formyl-3,5-diiodo-DL-thyronine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (-)-α-phenethylamine; water
2: hydrobromic acid
3: concentrated ammonia; potassium iodide; iodine
View Scheme
N-formyl-3,5-diiodo-L-thyronine
94298-44-9, 120408-14-2

N-formyl-3,5-diiodo-L-thyronine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrobromic acid
2: concentrated ammonia; potassium iodide; iodine
View Scheme
L-tyrosine
60-18-4

L-tyrosine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid; iodine monochloride
2: aq. NaOH solution; butanol-(1); aqueous hydrogen peroxide
View Scheme
Multi-step reaction with 8 steps
1: hydrogenchloride / water / 24 h / 20 °C
2: sodium hydrogencarbonate / water; tetrahydrofuran / 24 h / 20 °C
3: N-iodo-succinimide / dichloromethane / 0.67 h / 0 °C
4: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C
6: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C
7: lithium hydroxide / water; methanol / 1.5 h / 4 °C
8: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine disodium salt

O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine disodium salt

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 1h; pH=~ 4 - 5;
thyroxine
300-30-1

thyroxine

A

L-thyroxine
51-48-9

L-thyroxine

B

dextrothyroxine
51-49-0

dextrothyroxine

Conditions
ConditionsYield
With chiral stationary phase including isopropyl-functionalized CF6 In methanol; acetic acid; triethylamine; acetonitrile at 20℃; Purification / work up;
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate
1431868-09-5

methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium hydroxide / water; methanol / 1.5 h / 4 °C
2: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid

(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 20℃; Inert atmosphere;
L-Tyr-OMe
1080-06-4

L-Tyr-OMe

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: sodium hydrogencarbonate / water; tetrahydrofuran / 24 h / 20 °C
2: N-iodo-succinimide / dichloromethane / 0.67 h / 0 °C
3: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C
5: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C
6: lithium hydroxide / water; methanol / 1.5 h / 4 °C
7: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester
4326-36-7

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-iodo-succinimide / dichloromethane / 0.67 h / 0 °C
2: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C
4: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C
5: lithium hydroxide / water; methanol / 1.5 h / 4 °C
6: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-3,5-diiodophenyl)propanoate
128781-80-6

(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-3,5-diiodophenyl)propanoate

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C
3: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C
4: lithium hydroxide / water; methanol / 1.5 h / 4 °C
5: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
C30H43I2NO6Si
1016161-91-3

C30H43I2NO6Si

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C
2: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C
3: lithium hydroxide / water; methanol / 1.5 h / 4 °C
4: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
C21H23I2NO6
1431868-05-1

C21H23I2NO6

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C
2: lithium hydroxide / water; methanol / 1.5 h / 4 °C
3: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
3,5-diiodo L-tyrosine copper complex

3,5-diiodo L-tyrosine copper complex

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: diisopropylamine / water; butan-1-ol / 2 h / 20 - 90 °C
1.2: 2 h / 20 - 30 °C
2.1: acetic acid; hydrogen iodide / 5 h / 100 °C
3.1: methylamine / methanol / 25 - 30 °C
3.2: -8 - 0 °C
3.3: 15 - 20 °C
View Scheme
4,4'-dimethoxydiphenyliodonium iodide
6293-71-6

4,4'-dimethoxydiphenyliodonium iodide

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: diisopropylamine / water; butan-1-ol / 2 h / 20 - 90 °C
1.2: 2 h / 20 - 30 °C
2.1: acetic acid; hydrogen iodide / 5 h / 100 °C
3.1: methylamine / methanol / 25 - 30 °C
3.2: -8 - 0 °C
3.3: 15 - 20 °C
View Scheme
2-amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propanoic acid
94345-95-6

2-amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propanoic acid

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: acetic acid; hydrogen iodide / 5 h / 100 °C
2.1: methylamine / methanol / 25 - 30 °C
2.2: -8 - 0 °C
2.3: 15 - 20 °C
View Scheme
L-Lactic acid
79-33-4

L-Lactic acid

L-Tartaric acid
87-69-4

L-Tartaric acid

L-thyroxine
51-48-9

L-thyroxine

C4H6O6*C15H11I4NO4*C3H6O3

C4H6O6*C15H11I4NO4*C3H6O3

Conditions
ConditionsYield
at 10 - 20℃; for 168h;99.5%
L-thyroxine
51-48-9

L-thyroxine

L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
With sodium carbonate In water Reflux;98%
Stage #1: L-thyroxine With sulfuric acid; ammonia In butan-1-ol at 5 - 65℃; for 1h; pH=8;
Stage #2: With sodium hydroxide In propan-1-ol; butan-1-ol at 25 - 50℃; pH=10;
83%
With sodium carbonate Reflux;79.2%
With sodium carbonate In propan-1-ol; water at 80 - 90℃; for 1h;68%
L-Tartaric acid
87-69-4

L-Tartaric acid

L-thyroxine
51-48-9

L-thyroxine

C4H6O6*C15H11I4NO4

C4H6O6*C15H11I4NO4

Conditions
ConditionsYield
In ethanol for 72h;96%
L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With sodium sulfite In water at 130℃; for 2h; Sealed tube; Microwave irradiation; Green chemistry;92%
L-thyroxine
51-48-9

L-thyroxine

O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine disodium salt

O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine disodium salt

Conditions
ConditionsYield
With sodium hydroxide In propan-1-ol; water at 80 - 90℃;91%
With sodium hydroxide In ethanol for 0.25h; Reflux;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

L-thyroxine
51-48-9

L-thyroxine

(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid

(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 2h;90%
In N,N-dimethyl-formamide at 20℃; for 2h;90%
With triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;50%
With sodium carbonate In dimethyl sulfoxide
With hydrogenchloride; sodium hydrogencarbonate In N-methyl-acetamide; methanol; water4.2 g (4.8 mmol, 83%)
L-thyroxine
51-48-9

L-thyroxine

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

methyl (S)-2-amino-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate hydrochloride

methyl (S)-2-amino-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol; water87%
With hydrogenchloride In methanol; water87%
Boc-Val-ONSu
3392-12-9

Boc-Val-ONSu

L-thyroxine
51-48-9

L-thyroxine

N-(t-butoxycarbonyl)-L-valyl-L-thyroxine

N-(t-butoxycarbonyl)-L-valyl-L-thyroxine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; water at 20℃; Condensation;85%
L-thyroxine
51-48-9

L-thyroxine

oxalic acid
144-62-7

oxalic acid

C15H11I4NO4*C2H2O4

C15H11I4NO4*C2H2O4

Conditions
ConditionsYield
In ethanol at 10 - 20℃; for 120h;82.5%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

L-thyroxine
51-48-9

L-thyroxine

C16H9I4NO5

C16H9I4NO5

Conditions
ConditionsYield
In tetrahydrofuran at 50℃; for 1h;80%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

L-thyroxine
51-48-9

L-thyroxine

L-thyroxine-N-carboxyanhydride

L-thyroxine-N-carboxyanhydride

Conditions
ConditionsYield
In tetrahydrofuran at 50℃; for 1h; Inert atmosphere;80%
L-thyroxine
51-48-9

L-thyroxine

α-(N-Trifluoroacetyl)amino-β-[3,5-diiodo-4-(3',5'-diiodo-4'-hydroxyphenoxy)phenyl] propanoic acid
73122-01-7

α-(N-Trifluoroacetyl)amino-β-[3,5-diiodo-4-(3',5'-diiodo-4'-hydroxyphenoxy)phenyl] propanoic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate; trifluoroacetic acid; trifluoroacetic anhydride In water; ethyl acetate70.5%
With sodium hydrogencarbonate; trifluoroacetic acid; trifluoroacetic anhydride In water; ethyl acetate70.5%
L-thyroxine
51-48-9

L-thyroxine

ethyl iodide
75-03-6

ethyl iodide

2-(ethylamino)-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
1021496-83-2

2-(ethylamino)-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 2h;62%
In N,N-dimethyl-formamide at 20℃; for 2h;62%
butanoic acid anhydride
106-31-0

butanoic acid anhydride

L-thyroxine
51-48-9

L-thyroxine

2-(butyrylamino)-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
806620-06-4

2-(butyrylamino)-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;50%
Stage #1: L-thyroxine With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: butanoic acid anhydride In N,N-dimethyl-formamide at 20℃;
45%
Stage #1: L-thyroxine With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: butanoic acid anhydride In N,N-dimethyl-formamide at 20℃; for 0.75h;
45%
L-thyroxine
51-48-9

L-thyroxine

acetic anhydride
108-24-7

acetic anhydride

2-acetamido-3-[4-(4-acetoxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
26041-53-2

2-acetamido-3-[4-(4-acetoxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid

Conditions
ConditionsYield
Stage #1: L-thyroxine With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: acetic anhydride In N,N-dimethyl-formamide at 20℃;
50%
With pyridine at 0 - 23℃; for 12h; Inert atmosphere;
L-thyroxine
51-48-9

L-thyroxine

ethyl iodide
75-03-6

ethyl iodide

ethyl 2-(ethylamino)-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate
1083039-06-8

ethyl 2-(ethylamino)-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate

Conditions
ConditionsYield
Stage #1: L-thyroxine With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: ethyl iodide In N,N-dimethyl-formamide at 20℃; for 1h;
50%
Stage #1: L-thyroxine With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: ethyl iodide In N,N-dimethyl-formamide at 20℃;
10%
L-thyroxine
51-48-9

L-thyroxine

biotinamidocaproate N-hydroxysuccinimide ester
89889-52-1

biotinamidocaproate N-hydroxysuccinimide ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; dimethyl sulfoxide at 20℃; Cooling with ice;42%
L-thyroxine
51-48-9

L-thyroxine

L-thyroxine sulfate

L-thyroxine sulfate

Conditions
ConditionsYield
With chlorosulfonic acid; trifluoroacetic acid at 0℃; for 0.166667h;40%
L-thyroxine
51-48-9

L-thyroxine

methyl iodide
74-88-4

methyl iodide

potassium 3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-2-(methylamino)propanoate dihydrate
1234572-93-0

potassium 3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-2-(methylamino)propanoate dihydrate

Conditions
ConditionsYield
Stage #1: L-thyroxine; methyl iodide In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: With potassium carbonate In N,N-dimethyl-formamide
24%
Stage #1: L-thyroxine; methyl iodide With triiodothyronine In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: With potassium carbonate In water; N,N-dimethyl-formamide
24%
L-thyroxine
51-48-9

L-thyroxine

O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodo-L-tyrosine sodium salt

O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodo-L-tyrosine sodium salt

Conditions
ConditionsYield
Stage #1: L-thyroxine With chlorosulfonic acid In N,N-dimethyl acetamide at 0 - 20℃; for 5h; Inert atmosphere;
Stage #2: With sodium hydrogencarbonate; sodium carbonate In N,N-dimethyl acetamide; water for 1.5h;
18%
L-thyroxine
51-48-9

L-thyroxine

O-(4-hydroxyphenyl)-3,5-diiodo-L-tyrosine
1596-67-4

O-(4-hydroxyphenyl)-3,5-diiodo-L-tyrosine

Conditions
ConditionsYield
With potassium hydroxide; palladium Hydrogenation;
With sodium tetrahydroborate; C10H8STe; D,L-dithiothreitol In aq. phosphate buffer at 37℃; for 0.5h; pH=7.5; Reagent/catalyst;
L-thyroxine
51-48-9

L-thyroxine

chloroacetyl chloride
79-04-9

chloroacetyl chloride

N-chloroacetyl-3,5,3',5'-tetraiodo-L-thyronine
97738-15-3

N-chloroacetyl-3,5,3',5'-tetraiodo-L-thyronine

Conditions
ConditionsYield
With ethyl acetate
L-thyroxine
51-48-9

L-thyroxine

dimethyl sulfate
77-78-1

dimethyl sulfate

4-(3,5-diiodo-4-methoxy-phenoxy)-3,5-diiodo-trans-cinnamic acid

4-(3,5-diiodo-4-methoxy-phenoxy)-3,5-diiodo-trans-cinnamic acid

Conditions
ConditionsYield
With sodium hydroxide

51-48-9Downstream Products

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields