160142-25-6

Basic information

• Product Name: 2-(2-Methoxypropan-2-yl)pyrrolidine
• Synonyms: 2-(2-Methoxypropan-2-yl)pyrrolidine;2-(1-Methoxy-1-methyl-ethyl)-pyrrolidine;2-(2-Methoxypropan-2-yl)
• CAS NO: 160142-25-6
• Molecular Formula: C8H17NO
• Molecular Weight: 143.228
• Mol File: 160142-25-6.mol

Chemical Properties

• Boiling Point: 173.5 °C at 760 mmHg
• Flash Point: 65.4 °C
• Appearance: /
• Density: 0.91 g/cm³
• Vapor Pressure: 1.26mmHg at 25°C
• Refractive Index: 1.443
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-(2-Methoxypropan-2-yl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Methoxypropan-2-yl)pyrrolidine(160142-25-6)
• EPA Substance Registry System: 2-(2-Methoxypropan-2-yl)pyrrolidine(160142-25-6)

Safety Data

• Hazardous Substances Data: 160142-25-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-Methoxypropan-2-yl)pyrrolidine is used as a chemical intermediate for the synthesis of various medicinal agents due to its potential pharmacological activities.
Used in Chemical Research:
2-(2-Methoxypropan-2-yl)pyrrolidine is used as a research compound for studying the properties and potential applications of pyrrolidine derivatives in organic chemistry and drug development.

InChI:InChI=1/C8H17NO/c1-8(2,10-3)7-5-4-6-9-7/h7,9H,4-6H2,1-3H3

Upstream product

• 129173-93-9 (S)-N-formyl-2-(1-methoxy-1-methylethyl)pyrrolidine 
• 118970-96-0 (S)-(-)-1-benzyl-2-(1-methoxy-1-methylethyl)-pyrrolidine 
• 156358-43-9 (2S,3R)-1-[(S)-2-(1-Methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-5-methyl-1,2,3,4-tetrahydro-pyridine-2,3-dicarboxylic acid dimethyl ester 
• 121224-35-9 (S)-(-)-1-amino-2-(1'-methoxy-1'-methylethyl)pyrrolidine 
• 118970-92-6 (S)-(-)-1-benzyl-2-(1-hydroxy-1-methylethyl)-pyrrolidine 
• 92053-25-3 (S)-(-)-2-(1-hydroxy-1-methylethyl)-pyrrolidine 
• 129149-57-1 (S)-N-formyl-2-(1-hydroxy-1-methylethyl)pyrrolidine 
• 51207-68-2 (2S)-N-Benzyloxycarbony-2-(1'-hydroxy-1'-methylethyl)pyrrolidine 
• 5211-23-4 N-carbobenzyloxy-L-proline methyl ester 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 

Downstream Products

• 137720-43-5 (S)-N-(2-carbomethoxybenzoyl)-2-(1-methoxy-1-methylethyl)pyrrolidine 

Relevant articles and documents

Optically active 3-amino-2H-azirines as synthons for enantiomerically pure α,α-disubstituted α-amino acids: Synthesis of the α-methylphenylalanine synthons and some model peptides

The synthesis of a novel 2-benzyl-2-methyl-3-amino-2H-azirine derivative with a chiral amino group is described. Chromatographic separation of the diastereoisomer mixture yielded the pure diastereoisomers 9a and 9b which are the D- and L-2-methylphenylalanine ((α-Me)Phe) synthons, respectively. The reaction of 9a and 9b with thiobenzoic acid and with Z-leucine yielded the monothiodiamides 10a and 10b and the dipeptide derivatives 11a and 11b, respectively. Methanolysis of 11b yielded 12b. The absolute configuration of 10a was established by X-ray crystallography. The absolute configuration of (α-Me)Phe in 12b has been deduced from the known configuration of L-leucine.

Asymmetric Diels-Alder Reactions with Chiral 1-Azadienes

Chiral 1-azadienes 1 derived from α,β-unsaturated aldehydes and Enders' hydrazines cycloadd to cyclic dienophiles with high facial selectivities.The adducts can be readily converted into enantiomerically pure piperidine derivatives. - Keywords: asymmetric cycloadditions, 1-azadienes, piperidines.

A highly enantioselective synthesis of phosphate triesters

A general methodology for the preparation of both enantiomers of a variety of trialkyl phosphates with enantiomeric excesses ranging from 87 to 92% is described. Bis(2,4-dichlorophenyl) phosphoramidates bearing a 2-substituted pyrrolidine moiety as the chiral auxiliary are prepared and examined for their stereoselectivity. Considerations based on both the absolute configuration of the product phosphates as well as the X-ray structural determination of one of the bis(2,4-dichlorophenyl) phosphoramidates suggest these substitutions occur with preponderant inversion of configuration at phosphorus.

LARGE SCALE PREPARATION OF VERSATILE CHIRAL AUXILIARIES DERIVED FROM (S)-PROLINE

The synthesis of a variety of enantiomerically pure chiral auxiliaries based on (S)-proline and bearing sterically demanding side chains at the pyrrolidine moiety, such as the secondary amines (S)-3,5 and 7 and the hydrazines (S)-6, is described on a molar scale.As key step, the Grignard or RLi addition to the N-benzylated proline ester (S)-1 is used.