(Equation presented) A library of cycloimonium salts has been prepared through Westphal reaction in solid-phase. By reaction of solid-support-bound azolium or azinium acetates 2, 1,2-diketones 4, and base, cycloimonium salts 5 were synthesized in good to high yield and purities.
Delgado, Francisca,Linares, M. Lourdes,Alajarin, Ramon,Vaquero, Juan J.,Alvarez-Builla, Julio
Microwave assisted Westphal condensation and its application to synthesis of sempervirine and related compounds
A concise synthesis of a potent lead in anticancer therapeutics, sempervirine, was achieved by one pot Westphal condensation, ester hydrolysis, and decarboxylation under microwave irradiation. The method was extended to the synthesis of several similar he
Chinta Rao,Saha, Sanjay,Raolji, Gajendra B.,Patro, Balaram,Risbood, Prabhaker,Difilippantonio, Michael J.,Tomaszewski, Joseph E.,Malhotra, Sanjay V.
supporting information
p. 487 - 490
(2013/02/25)
2-Methylpyridinium Salts as 1,4-Dinucleophiles. Quinolizinium Salts from the Westphal Condensation
Condensation of 2-methylpyridinium salts with 1,2-dicarbonyls in the presence of base, yielded 2,3-disubstituted quinolizinium compounds.Results obtained with different pyridinium substrates are discussed.
Alvarez-Builla, J.,Trigo, G. Gonzales,Ezquerra, J.,Fombella, M.E.
p. 681 - 685
(2007/10/02)
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