16183-32-7Relevant articles and documents
Single source precursor synthesized CuS nanoparticles for NIR phototherapy of cancer and photodegradation of organic carcinogen
Arshad, Mehwish,Wang, Zhaojie,Nasir, Jamal Abdul,Amador, Eric,Jin, Mingwu,Li, Haibin,Chen, Zhigang,Rehman, Zia ur,Chen, Wei
, (2021)
Herein, we report cost effective and body compatible CuS nanoparticles (NPs) derived from a single source precursor as photothermal agent for healing deep cancer and photocatalytic remediation of organic carcinogens. These NPs efficiently kill MCF7 cells
Rhodium catalysts with cofactor mimics for the biomimetic reduction of CN bonds
Chen, Fushan,Deng, Li,Dong, Wenjin,Tang, Jie,Xian, Mo
, p. 5564 - 5569 (2021/08/25)
A strategy based on the cooperation between metal and bonded cofactor mimics was applied to the transfer hydrogenation of CN bonds. We designed and synthesized a rhodium complex containing a 1,3-dimethylbenzoimidazole moiety, which could transfer hydride from a rhodium center to imine substrates in a biomimetic way. Under both transfer hydrogenation and reductive amination reaction conditions, the catalyst exhibited good selectivity towards CN bonds. With the catalyst, 34 imines were transfer hydrogenated to corresponding amines and a key intermediate of retigabine was prepared via reductive amination in a greener way. According to the NMR observations and isotope experiments, a plausible mechanism for this biomimetic reduction of CN bonds were proposed.
Polyoxometalate-Driven Ease Conversion of Valuable Furfural to trans- N, N-4,5-Diaminocyclopenten-2-ones
Fountoulaki, Stella,Lykakis, Ioannis N.,Tzani, Marina A.
, (2022/02/10)
We investigated the catalytic efficacy of silicotungstic acid (H4SiW12O40) polyoxometalate (POM) toward the reaction between furfural and amines that selectively yields trans-N,N-4,5-substituted-diaminocyclopenten-2-ones (trans-DACPs). H4SiW12O40 facilita
Bio-inspired transition metal-organic hydride conjugates for catalysis of transfer hydrogenation: Experiment and theory
McSkimming, Alex,Chan, Bun,Bhadbhade, Mohan M.,Ball, Graham E.,Colbran, Stephen B.
, p. 2821 - 2834 (2015/02/05)
Taking inspiration from yeast alcohol dehydrogenase (yADH), a benzimidazolium (BI+) organic hydride-acceptor domain has been coupled with a 1,10-phenanthroline (phen) metal-binding domain to afford a novel multifunctional ligand (LBI+/sup
Bio-inspired catalytic imine reduction by rhodium complexes with tethered hantzsch pyridinium groups: Evidence for direct hydride transfer from dihydropyridine to metal-activated substrate
McSkimming, Alex,Bhadbhade, Mohan M.,Colbran, Stephen B.
supporting information, p. 3411 - 3416 (2013/05/08)
Inspired by Nature: A conceptually new design for a catalyst, combining a metal center abutted to an organic hydride donor, is demonstrated for the formate-driven transfer hydrogenation of imines under ambient conditions. A key step, transfer of hydride from the organohydride donor to the metal-polarized substrate, mirrors that in metallo-(de)hydrogenase enzymes.
SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS
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Page/Page column 216, (2012/12/13)
Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.
1,2,3-Triazole-boranes: Stable and efficient reagents for ketone and aldehyde reductive amination in organic solvents or in water
Liao, Wenyan,Chen, Yunfeng,Liu, Yuxiu,Duan, Haifeng,Petersen, Jeffrey L.,Shi, Xiaodong
supporting information; experimental part, p. 6436 - 6438 (2010/03/04)
Air, moisture and thermally stable 1,2,3-triazole-borane complexes were developed as new practical reagents for ketone/aldehyde amination with high efficiency and excellent substrate diversity.
Sodium borohydride-iodine, an efficient reagent for reductive amination of aromatic aldehydes
Saxena, Ira,Borah, Ruli,Sarma, Jadab C.
, p. 1970 - 1971 (2007/10/03)
Reactions of aromatic aldehydes with primary amines give the corresponding secondary amines in the presence of iodine and sodium borohydride in methanol.
Reductive amination of aromatic aldehydes and ketones with nickel boride
Saxena, Ira,Borah, Ruli,Sarma, Jadab C.
, p. 503 - 504 (2007/10/03)
The reductive amination of aromatic aldehydes and ketones with nickel boride was investigated. The reactions of aromatic aldehydes and ketones with primary amines produced corresponding secondary amines in the presence of in situ generated nickel boride. The secondary amines were found to remain inert in the system.
Composition for treating depression with (N-heteroaryl)alkylamines
-
, (2008/06/13)
The invention concerns compounds having formula: STR1 or a salt thereof, wherein E represents hydrogen, lower alkyl or a group Ar 1 --A 1 --; Ar and Ar 1 are the same or different aryl groups (including heteroaryl) which are optionally substituted, eg by one or more substituents commonly used in pharmaceutical chemistry; A and A 1 are the same or different alkylene groups having one or two carbon atoms linking Ar or Ar 1 to N and optionally substituted by lower alkyl and/or optionally substituted aryl, B is an alkylene group of 3 or 4 carbon atoms, which may be substituted by lower alkyl; D 1 represents halogen, CH 3, CR 1 R 2 NH 2, SO 3 H or SO 2 NR 6 R 7 where R 1 and R 2 are independently hydrogen or lower alkyl and R 6 and R 7 are each hydrogen, lower alkyl or aralkyl of 7 to 12 carbon atoms or R 6 and R 7 together with the nitrogen atom to which they are attached represent a 5 or 6 membered ring, which compounds are useful, for treating depression or cerebral insufficiency or dementias in animals.