162148-16-5Relevant articles and documents
Industrialized scale preparation method for pidotimod
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Paragraph 0018; 0021; 0023; 0025; 0027, (2018/11/03)
The invention discloses an industrialized scale preparation method for pidotimod, and belongs to the technical field of medicine synthesis. The industrialized scale preparation method comprises the following steps of performing ring closure and esterification on L-cysteine, so as to obtain L-thiazolidine-carboxylic ester; then, condensing with L-pyroglutamic acid under the action of a condensing agent; then, performing ester hydrolysis, and crystallizing, so as to obtain a product meeting the medicinal standard. The industrialized scale preparation method has the advantages that the intermediate, such as L-thiazolidine-carboxylic ester hydrochloride, is not separated, the water is removed by a co-boiling method in the condensing reaction process, and the separating and drying steps of theintermediate are omitted; compared with other preparation methods, the technology is optimized, so as to shorten the large-scale production time, improve the yield rate, and reduce the production cost; the operability in the scale production of the pidotimod is realized.
Synthesis and preliminary pharmacological evaluation of pidotimod, its enantiomer, diastereomers and carboxamido derivatives
Magni,Signorelli,Bocchiola
, p. 1402 - 1404 (2007/10/02)
A new compound with a peptide-like structure, (R)-3-[(S)-(5-oxo-2-pyrrolidinyl)carbonyl]-thiazolidine-4-carboxylic acid, its enantiomer, diastereomers and carboxamido derivatives were synthesized and tested for immunostimulant activity. Synthesis, preliminary, pharmacological data and structure-activity relationship are reported. (R)-3-[1(S)-(5-Oxo-2-pyrrolidinyl)carbonyl]-thiazolidine-4-carboxylic acid (1b, Pidotimod, PGT/1A, CAS 121808-62-6) was selected for further research.