28990-85-4

Basic information

• Product Name: L-PYROGLUTAMIC ACID PENTACHLOROPHENYL ESTER
• Synonyms: PYROGLUTAMIC ACID-OPCP;PYR-OPCP;H-PYR-OPCP;L-PYROGLUTAMIC ACID PENTACHLOROPHENYL ESTER;perchlorophenyl 5-oxo-L-prolinate;(2S)-5-Oxo-2-pyrrolidinecarboxylic acid pentachlorophenyl ester;5-Oxo-L-proline pentachlorophenyl ester;L-Pyroglutamic acid pentachlorophenyl ester≥ 99% (Elemental Analysis)
• CAS NO: 28990-85-4
• Molecular Formula: C₁₁H₆Cl₅NO₃
• Molecular Weight: 377.44
• EINECS: 249-360-2
• Product Categories: Amino Acids;I - Z;Modified Amino Acids
• Mol File: 28990-85-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 185-190°C
• Boiling Point: 559.9 °C at 760 mmHg
• Flash Point: 292.4 °C
• Appearance: /
• Density: 1.683 g/cm³
• Vapor Pressure: 1.45E-12mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: -15°C
• PKA: 14.22±0.40(Predicted)
• CAS DataBase Reference: L-PYROGLUTAMIC ACID PENTACHLOROPHENYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: L-PYROGLUTAMIC ACID PENTACHLOROPHENYL ESTER(28990-85-4)
• EPA Substance Registry System: L-PYROGLUTAMIC ACID PENTACHLOROPHENYL ESTER(28990-85-4)

Safety Data

• WGK Germany: WGK 3 highly water endangering
• Hazardous Substances Data: 28990-85-4(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C11H6Cl5NO3/c12-5-6(13)8(15)10(9(16)7(5)14)20-11(19)3-1-2-4(18)17-3/h3H,1-2H2,(H,17,18)/t3-/m0/s1

Upstream product

• 87-86-5 Pentachlorophenol 
• 98-79-3 L-Pyroglutamic acid 

Downstream Products

• 81638-99-5 (S)-5-Oxo-pyrrolidine-2-carboxylic acid (4-piperidin-1-yl-but-2-ynyl)-amide 
• 103322-29-8 L-pyroglutamyl-L-asparagine amide 
• 121808-62-6 pidotimod 
• 162148-17-6 (S)-3-<(S)-(5-oxo-2-pyrrolidinyl)carbonyl>-thiazolidine-4-carboxylic acid 
• 81639-01-2 (S)-5-Oxo-pyrrolidine-2-carboxylic acid [4-((2S,6R)-2,6-dimethyl-piperidin-1-yl)-but-2-ynyl]-amide 
• 81639-00-1 (S)-5-Oxo-pyrrolidine-2-carboxylic acid (4-azocan-1-yl-but-2-ynyl)-amide 
• 61123-13-5 pyroglutamyl-phenylalanyl-phenylalanine-glycyl-leucyl-methionine amide 

Relevant articles and documents

Designing nootropic dipeptides using an evolutionary-genetic approach

A novel approach to the search for the new groups of biologically active peptides is developed, which is based on the selection of point mutants with respect to noncritical amino acid residues. Using a gene site encoding the arginine vasopressin AVP(4-5) sequence, which corresponds to the pGlu-Asn-NH2 nootropic dipeptide, three point mutants with respect to Asn (pGlu-Ser-NH2, pGlu-Asp-NH2, and pGlu-His-NH 2) have been synthesized. The first two peptides (corresponding to transitions of the 1st and 2nd bases, respectively) display nootropic activity in the passive avoidance test in rats at a dose of 0.1 mg/kg (i.p.). The last peptide (corresponding to a transversion of the 1st base) proved to be inactive. Both active peptides exhibit electronic and structural differences from the parent dipeptide: pGlu-Asp-NH2 bears a negative charge and contains a primary alcohol group instead of the amide moiety. Using the proposed method, it is possible to create genetically related analogs of well-known neuropeptides with substantially different structures.