162221-97-8

Basic information

• Product Name: 4-(4-bromophenyl)-5-phenyl-4H-1,2,4-triazol-3-yl hydrosulfide
• Synonyms: 4-(4-bromophenyl)-5-phenyl-4H-1,2,4-triazol-3-yl hydrosulfide
• CAS NO: 162221-97-8
• Molecular Formula: C₁₄H₁₀BrN₃S
• Molecular Weight: 332.2183
• Mol File: 162221-97-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-bromophenyl)-5-phenyl-4H-1,2,4-triazol-3-yl hydrosulfide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-bromophenyl)-5-phenyl-4H-1,2,4-triazol-3-yl hydrosulfide(162221-97-8)
• EPA Substance Registry System: 4-(4-bromophenyl)-5-phenyl-4H-1,2,4-triazol-3-yl hydrosulfide(162221-97-8)

Safety Data

• Hazardous Substances Data: 162221-97-8(Hazardous Substances Data)

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 1985-12-2 4-Bromophenyl isothiocyanate 
• 100-52-7 benzaldehyde 
• 2646-31-3 4-(p-bromophenyl)thiosemicarbazide 
• 38240-75-4 1-benzoyl-4-(4-bromophenyl)thiosemicarbazide 

Downstream Products

• 1516888-34-8 4-(4-bromophenyl)-5-phenyl-3-(2,3,4,6-tetra-O-acetyl-β-D-1-thioglucopyranose)-1,2,4-triazole 
• 1516888-09-7 4-(4-bromophenyl)-5-phenyl-3-(2,3,4,6-tetra-O-acetyl-β-D-1-thiogalactopyranose)-1,2,4-triazole 
• 1326882-31-8 4-(4-bromophenyl)-2-(morpholin-4-ylmethyl)-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 1326830-45-8 4-(4-bromophenyl)-5-phenyl-2-(piperidin-1-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 1403137-21-2 4-(4-bromophenyl)-5-phenyl-2-(pyrrolidin-1-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 1403137-18-7 4-(4-bromophenyl)-2-[(diethylamino)methyl]-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione 

Relevant articles and documents

Synthesis of 1,2,4-Triazoles via Oxidative Heterocyclization: Selective C-N Bond over C-S Bond Formation

The higher propensity of C-N over C-S bond forming ability was demonstrated, through formal C-H functionalization during the construction of 4,5-disubstituted 1,2,4-triazole-3-thiones from arylidenearylthiosemicarbazides catalyzed by Cu(II). However, ster

Antimicrobial and Physicochemical Characterizations of Thiosemicarbazide and S-Triazole Derivatives

Two series of thiosemicarbazide derivatives and three series of s-triazole derivatives have been synthesized. All of these compounds were tested for their in vitro antibacterial activity against Gram-positive and Gram-negative bacterial strains. Among tested thiosemicarbazide derivatives, the best bioactivity was detected for two 1-formylthiosemicarbazides with 3-/4-tolyl substitution (1 l, 1 m) (MICs range between 31.25 and 250 μg/mL). All tested s-triazole derivatives exhibited lower antibacterial activity than their acyclic precursors.

Synthesis of new 1,2,4-Triazole-5-thiones and their thioglycoside derivatives as potential antibacterial agents

Abstract The glycosylation of 1,2,4-triazole-5-thiones has been performed with peracetylated β-pyranosyl bromide in the presence of potassium carbonate. The synthesized compounds were tested for their antimicrobial activity against bacterial (Gram-negative and Gram-positive) and yeasts strains in vitro. The synthetic compounds showed different inhibition zones against tested bacterial and yeasts strains. Among them, compounds which possessed 2-furyl and p-bromophenyl moieties showed the best results against Acinetobacter calcoaceticus ATCC 23055.

Microbiologically active Mannich bases derived from 1,2,4-triazoles. the effect of C-5 substituent on antibacterial activity

Our research proved that chemical character of the C-5 substituent significantly determines the antibacterial activity of the Mannich bases derived from 4,5-disubstituted 1,2,4-triazole-3-thiones. This activity was considerably increased by an introduction of a chlorine atom to the phenyl ring. The obtained compounds were particularly active against opportunistic bacteria (Bacillus subtilis and Bacillus cereus). The antibacterial activity of some Mannich bases was similar or higher than the activity of commonly used antibiotics such as ampicillin and cefuroxime.

Synthesis and tuberculostatic activity of some 2-piperazinmethylene derivatives 1,2,4-triazole-3-thiones

The Mannich reaction's products of 1,2,4-triazole-3-thiones, substituted in position 4 (with ethyl, allyl, phenyl, Ph-4-Br) or 5 (with phenyl, Ph-4-OH, Ph-3,4,5-(OMe)3, 2-phenyl) were obtained. Their amino-components were 1-phenylpiperazine, 1-