16227-06-8Relevant articles and documents
Selective and reusable iron(II)-based molecular sensor for the vapor-phase detection of alcohols
Naik, Anil D.,Robeyns, Koen,Meunier, Christophe F.,Leonard, Alexandre F.,Rotaru, Aurelian,Tinant, Bernard,Filinchuk, Yaroslav,Su, Bao Lian,Garcia, Yann
, p. 1263 - 1265 (2014)
A mononuclear iron(II) neutral complex (1) is screened for sensing abilities for a wide spectrum of chemicals and to evaluate the response function toward physical perturbation like temperature and mechanical stress. Interestingly, 1 precisely detects methanol among an alcohol series. The sensing process is visually detectable, fatigue-resistant, highly selective, and reusable. The sensing ability is attributed to molecular sieving and subsequent spin-state change of iron centers, after a crystal-to-crystal transformation.
The synthesis, property and reduction of high-nitrogen compound 3,3′,5,5′-tetraazido-4,4′-bis(1,2,4-triazole)
Lu, Feipeng,Wang, Engyu,Huang, Jinglun,Huang, Ming,Nie, Fude,Chen, Fu-Xue
, p. 445 - 452 (2016)
High-nitrogen compound, 3,3′,5,5′-tetraazido-4,4′-bis(1,2,4-triazole) (TABT, 83.99% N), is synthesized from sodium azide and 3,3′,5,5′-tetrabromo-4,4′-bis(1,2,4-triazole) (TBBT) which is prepared by the bromination of 4,4′-bis(1,2,4-triazole) (BTz). It is fully characterized by IR, HRMS, NMR, and single crystal X-ray diffraction showing two triazole rings of TABT perpendicular to each other. DSC and TGA are employed to study TABT's thermal stability with a decomposition temperature at 125.39?°C (onset). The calculated detonation heat of TABT and the predicted detonation velocity are 6449?kJ·kg?1and 8649?m·s?1, respectively. The reduction of TABT with hydrogen and Pd/C gave the stabilized 3,3′,5,5′-tetra(t-butyloxycarbamido)-4,4′-bis(1,2,4-triazole) (11) in the presence of (Boc)2O, providing an alternative path to the high energy density material (HDEM) TNBT [3,3′,5,5′-tetranitro-4,4′-bis(1,2,4-triazole)].
Highly N/O co-doped ultramicroporous carbons derived from nonporous metal-organic framework for high performance supercapacitors
Gu, Yangyi,Miao, Ling,Yin, Ying,Liu, Mingxian,Gan, Lihua,Li, Liangchun
supporting information, p. 1491 - 1496 (2020/10/19)
A new nonporous Zn-based metal-organic framework (NPMOF) synthesized from a high nitrogen-containing rigid ligand was converted into porous carbon materials by direct carbonization without adding additional carbon sources. A series of NPMOF-derived porous carbons with very high N/O contents (24.1% for NPMOF-700, 20.2% for NPMOF-800, 15.1% for NPMOF-900) were prepared by adjusting the pyrolysis temperatures. The NPMOF-800 fabricated electrode exhibits a high capacitance of 220 F/g and extremely large surface area normalized capacitance of 57.7 μF/cm2 compared to other reported MOF-derived porous carbon electrodes, which could be attributed to the abundant ultramicroporosity and high N/O co-doping. More importantly, symmetric supercapacitor assembled with the MOF-derived carbon manifests prominent stability, i.e., 99.1% capacitance retention after 10,000 cycles at 1.0 A/g. This simple preparation of MOF-derived porous carbon materials not only finds an application direction for a variety of porous or even nonporous MOFs, but also opens a way for the production of porous carbon materials for superior energy storage.
Practical Synthesis of Cap-4 RNA
Leiter, Josef,Reichert, Dennis,Rentmeister, Andrea,Micura, Ronald
, p. 265 - 271 (2019/11/16)
Eukaryotic mRNAs possess 5′ caps that are determinants for their function. A structural characteristic of 5′ caps is methylation, with this feature already present in early eukaryotes such as Trypanosoma. While the common cap-0 (m7GpppN) shows
C6–O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents
Hulpia, Fabian,Bouton, Jakob,Campagnaro, Gustavo D.,Alfayez, Ibrahim A.,Mabille, Dorien,Maes, Louis,de Koning, Harry P.,Caljon, Guy,Van Calenbergh, Serge
, (2020/01/13)
African trypanosomiasis, a deadly infectious disease caused by the protozoan Trypanosoma brucei spp., is spread to new hosts by bites of infected tsetse flies. Currently approved therapies all have their specific drawbacks, prompting a search for novel th
METHODS AND CATALYSTS FOR CONVERTING METHANE TO METHANOL
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Paragraph 0154, (2018/06/15)
The invention encompasses methods of directly converting methane- to methanol The invention further encompasses catalysts that efficiently afford this transformation at low temperatures. Exemplary embodiments encompassed by the invention include a gas stream containing methane gas and oxygen,—which is passed over an oxygen-activated catalyst to directly form methanol
Isosteric Substitution of 4 H-1,2,4-Triazole by 1 H-1,2,3-Triazole in Isophthalic Derivative Enabled Hydrogel Formation for Controlled Drug Delivery
H?ring, Marleen,Rodríguez-López, Julio,Grijalvo, Santiago,Tautz, Markus,Eritja, Ramón,Martín, Víctor S.,Díaz Díaz, David
, p. 2963 - 2972 (2018/08/17)
In this work, we demonstrated that the simple substitution of the 1,2,4-triazole moiety in 5-(4H-1,2,4-triazol-4-yl)isophthalic acid (5-TIA) by the 1H-1,2,3-triazol-5-yl unit enables the preparation of a hydrogelator (click-TIA). In sharp contrast to 5-TIA, its isostere click-TIA undergoes self-assembly in water upon sonication, leading to the formation of stable supramolecular viscoelastic hydrogels with a critical gelation concentration of 6 g/L. Hydrogels made of click-TIA as well as hybrid hydrogels made of the mixture click-TIA + 5-TIA (molar ratio 1:0.2) were used to compare different properties of the materials (i.e., rheological properties, thermal properties, mechanical stability, morphology). In terms of toxicity, neither click-TIA nor 5-TIA showed cytotoxic effects on cellular viability of HeLa cells up to 2.3 × 10-3 g/L when compared to untreated cells incubated with DMSO. Furthermore, the hydrogels were used for the encapsulation and in vitro controlled release of oxytetracycline that followed first-order kinetics. For the hydrogel made of click-TIA, a maximum drug release of ～60% was reached after ～8 h within a pH range between 6.5 and 10. However, the release rate was reduced to approximately half of its value at pH values between 1.2 and 5.0, whereas the use of hybrid hydrogels made of click-TIA + 5-TIA allowed to reduce the original rate at pH ≤ 6.5.
Practical Synthesis of a 6-Triazolylazabicyclo[3.1.0]hexane
Sirois, Lauren E.,Xu, Jie,Angelaud, Remy,Lao, David,Gosselin, Francis
, p. 728 - 735 (2018/06/26)
We describe a practical, scalable synthesis of an advanced heterocyclic intermediate, (1R,5S,6s)-6-(4H-1,2,4-triazol-4-yl)-3-azabicyclo[3.1.0]hexane. A robust synthetic sequence based on a Kulinkovich-de Meijere pyrroline cyclopropanation followed by tran
Microporous Metal-Organic Framework Stabilized by Balanced Multiple Host-Couteranion Hydrogen-Bonding Interactions for High-Density CO2 Capture at Ambient Conditions
Ye, Yingxiang,Xiong, Shunshun,Wu, Xiaonan,Zhang, Liuqin,Li, Ziyin,Wang, Lihua,Ma, Xiuling,Chen, Qian-Huo,Zhang, Zhangjing,Xiang, Shengchang
supporting information, p. 292 - 299 (2016/01/15)
Microporous metal organic frameworks (MOFs) show promising application in several fields, but they often suffer from the weak robustness and stability after the removal of guest molecules. Here, three isostructural cationic metal-organic frameworks {[(Cu4Cl)(cpt)4(H2O)4]·3X·4DMAc·CH3OH·5H2O} (FJU-14, X = NO3, ClO4, BF4; DMAc = N,N′-dimethylacetamide) containing two types of polyhedral nanocages, one octahedron, and another tetrahedron have been synthesized from bifunctional organic ligands 4-(4H-1,2,4-triazol-4-yl) benzoic acid (Hcpt) and various copper salts. The series of MOFs FJU-14 are demonstrated as the first examples of the isostructural MOFs whose robustness, thermal stability, and CO2 capacity can be greatly improved via rational modulation of counteranions in the tetrahedral cages. The activated FJU-14-BF4-a containing BF4- anion can take CO2 of 95.8 cm3 cm-3 at ambient conditions with an adsorption enthalpy only of 18.8 kJ mol-1. The trapped CO2 density of 0.955 g cm-3 is the highest value among the reported MOFs. Dynamic fixed bed breakthrough experiments indicate that the separation of CO2/N2 mixture gases through a column packed with FJU-14-BF4-a solid can be efficiently achieved. The improved robustness and thermal stability for FJU-14-BF4-a can be attributed to the balanced multiple hydrogen-bonding interactions (MHBIs) between the BF4- counteranion and the cationic skeleton, while the high-density and low-enthalpy CO2 capture on FJU-14-BF4-a can be assigned to the multiple-point interactions between the adsorbate molecules and the framework as well as with its counteranions, as proved by single-crystal structures of the guest-free and CO2-loaded FJU-14-BF4-a samples.
Extraordinary Separation of Acetylene-Containing Mixtures with Microporous Metal-Organic Frameworks with Open O Donor Sites and Tunable Robustness through Control of the Helical Chain Secondary Building Units
Yao, Zizhu,Zhang, Zhangjing,Liu, Lizhen,Li, Ziyin,Zhou, Wei,Zhao, Yunfeng,Han, Yu,Chen, Banglin,Krishna, Rajamani,Xiang, Shengchang
, p. 5676 - 5683 (2016/04/20)
Acetylene separation is a very important but challenging industrial separation task. Here, through the solvothermal reaction of CuI and 5-triazole isophthalic acid in different solvents, two metal-organic frameworks (MOFs, FJU-21 and FJU-22) with open O donor sites and controllable robustness have been obtained for acetylene separation. They contain the same paddle-wheel {Cu2(COO2)4} nodes and metal-ligand connection modes, but with different helical chains as secondary building units (SBUs), leading to different structural robustness for the MOFs. FJU-21 and FJU-22 are the first examples in which the MOFs' robustness is controlled by adjusting the helical chain SBUs. Good robustness gives the activated FJU-22 a, which has higher surface area and gas uptakes than the flexible FJU-21 a. Importantly, FJU-22 a shows extraordinary separation of acetylene mixtures under ambient conditions. The separation capacity of FJU-22 a for 50:50 C2H2/CO2 mixtures is about twice that of the high-capacity HOF-3, and its actual separation selectivity for C2H2/C2H4 mixtures containing 1 % acetylene is the highest among reported porous materials. Based on first-principles calculations, the extraordinary separation performance of C2H2 for FJU-22 a was attributed to hydrogen-bonding interactions between the C2H2 molecules with the open O donors on the wall, which provide better recognition ability for C2H2 than other functional sites, including open metal sites and amino groups.
